Mill_lab

Me in front of the ABRCMS sign

16 (! What?) years ago I went to my first ABRCMS and was welcomed and encouraged to pursue my scientific dreams. I met folks that provided direct feedback on my graduate school applications and served a pivotal role in my career. I am honored return and give back again as faculty.
#ABRCMS2025

Updates for how to request childcare supplements for individual fellowships and institutional training grants. grants.nih.gov/grants/guide...

VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity - preLights Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism.

On how Vangl2 shapes the heart❤️

Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism. #preprint from the team of @meilhacsigolene.bsky.social

#preLight by @prakash-patterns.bsky.social⬇️
prelights.biologists.com/highlights/v...

SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT

We’re recruiting an institute director, take a look!

👇🏻

Do you want to do some frontier of knowledge research? There's still time to register for the next webinar of @hfspo.bsky.social

By far one of the best agencies I've worked with for my beloved HFSP project, even if it's a bumpy road...no risk no glory...

www.hfsp.org/hfsp-events/...

Key transcripts encoded centrin-like proteins, a frequent component of sensory/contractile structures in protists. We visualized tentacle ultrastructure by U-ExM with @dudinlab.bsky.social lab, discovering stunning tip and collar structures 🤯that add structural complexity to new tentacle formation.

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

To hear more about Rudolfo’s research, published in #JCSciliaSI, join us at the 53rd BSCB GenSoc UK Cilia and Centrosome Network e-symposium.
www.eventbrite.co.uk/e/bscb-genso...

YouTube video by The Company of Biologists JCS snapshot - Renal tissue-resident macrophages promote cystogenesis in polycystic kidney disease

New JCS snapshot - Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease

Rudolfo Karl presents the key findings from their recent JCS paper with Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social & team.
#JCSciliaSI

youtu.be/RDr146QtTx4

I guess it never gets old...bc we love #CellMigration

ATP has many roles: energy currency, hydrotrope, and *danger signal*

Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!

www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬

An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...

Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...

Figure showing that tissue-resident macrophages promote cytogenesis in an in vitro 3D model system.

Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...

Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies

Correct guidance link: grants.nih.gov/grants/guide...

Updated guidance about study sections and due dates during the shut down. (Given the number of emails about issues with submission/letters of rec I had, this will help with those). grants.nih.gov/grants/guide...

JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News

While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.

And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!

Next Gen Pregnancy Initiative - Burroughs Wellcome Fund by

The Next Gen Pregnancy Initiative is now accepting applications. Up to $500,000 over 4 years to support bold research into pregnancy duration, fetal growth, and pregnancy complications. Deadline: Dec 4, 2025.
Apply now buff.ly/rNhJKMW #bwfrepro

Enabling options for review: from training and transparency to author-centered AI tools - openRxiv Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...

Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n

openrxiv.org/enabling-rev...

Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the ‘handedness’ of the flagellar shapes at different points in their cycle.
#JCSciliaSI
journals.biologists.com/jcs/article/...

Candid photo of Zara Weinberg. She has short red hair, bangs and glasses. She is laughing.

The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.

The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.

www.leadingedgesymposium.org/apply/

👉Do not miss talks by our coordinator Sophie Saunier and by John Sayer at #KidneyWk 2025 in Houston, TX, the meeting of the @asnkidney.bsky.social - 📅Thursday Nov 6th, 2pm, Room310A - 💊Leading Edge of Therapeutic Development in Cystic Kidney Disease session #NPH #ciliopathies @hkd-l.bsky.social

So excited that our paper is now out with @jcellsci.bsky.social and a special thank you to the editors for featuring our work! Check out below! 🐸🔬

Amanda Smith, Lawrence Ostrowski and colleagues find that lipid nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models.
#JCSciliaSI
journals.biologists.com/jcs/article/...

Machine Learning Analysis of Cilia-Driven Particle Transport Distinguishes Primary Ciliary Dyskinesia Cilia from Normal Cilia Rational. Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia and abnormal mucociliary clearance. Despite advances in understanding the pathogenesis of PCD, diagnos...

I am excited to share our preprint on the use of machine learning to identify abnormal cilia function. I am proud of Nicholas Hadas, a talented PhD candidate, for his hard work in compiling the code and preparing this manuscript.
www.biorxiv.org/content/10.1...

#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!

We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.

Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.

Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella

journals.biologists.com/jcs/issue/13...

Love it when a plan comes so FABULOUSLY together- you and Miao are masters of MIPs!