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Mill_lab

@cilialab.bsky.social

Group at MRC HGU using genetics, cell biology and lots of imaging to unlock the mysteries of mammalian #cilia. #cilia. #centrioles #cytoskeleton #RareDisease www.cilialab.co.uk

2,551 Followers  |  1,426 Following  |  157 Posts  |  Joined: 06.09.2023  |  2.0768

Latest posts by cilialab.bsky.social on Bluesky

Open Call for Expressions of Interest in Max Planck Directorships:
Expressions of interest can be submitted until 31 October 2025.

Open Call for Expressions of Interest in Max Planck Directorships: Expressions of interest can be submitted until 31 October 2025.

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. โžก๏ธ mpg.de/directors - Please share the Open Call among potential candidates.

01.08.2025 09:06 โ€” ๐Ÿ‘ 143    ๐Ÿ” 174    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 10
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Sometimes life just alignsโ€ฆ

02.08.2025 18:45 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Using information from 7,350 journals, the average APC reported worldwide was $1,235.51 ($0.01 to $8,900.00). One APC was removed from analysis as an extreme outlier ($15,584,416.00 USD). What journal was this???

31.07.2025 20:43 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 0

Congratulations Girish @dyneinassembly.bsky.social and team- super well deserved! ๐Ÿงช๐Ÿ‘๐Ÿ‘ #cilia #motors

31.07.2025 17:05 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Head of the Cell Biology and Biophysics Unit The European Molecular Biology Laboratory (EMBL) is Europeโ€™s flagship life sciences organisation, and one of the worldโ€™s leading research institutions. An intergovernmental organisation of 29 Member S...

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

29.07.2025 07:50 โ€” ๐Ÿ‘ 53    ๐Ÿ” 64    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 4
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We have something for everyone- CSF flow & #neurodegeneration, ciliary trafficking of PKD2 complexes, cilia & #actin dynamics, #DNADamageResponse & multiciliation, cilia & pituitary development & transcriptional control of ciliogenesis... Great breaking science & rising talent to be showcased...๐Ÿงช

29.07.2025 10:17 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

Peak #SummerFun- our amazing line-up for our 52nd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 19/08/2025 15:00-17:45 is now live! Join us for all things #cilia & #centrosomes- free & open to all. Register for here- www.eventbrite.co.uk/e/1220921258...

29.07.2025 10:12 โ€” ๐Ÿ‘ 13    ๐Ÿ” 6    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Save the date!
March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? ๐Ÿฅณ
Stay tuned for more info!

29.07.2025 08:50 โ€” ๐Ÿ‘ 28    ๐Ÿ” 11    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3
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Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com โš›๏ธ

โžก๏ธ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony ๐ŸŽ‰ @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social ๐Ÿ˜†

29.07.2025 09:04 โ€” ๐Ÿ‘ 59    ๐Ÿ” 26    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3
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An international team of researchers, including #IGC's @cilialab.bsky.social, is investigating one of the bodyโ€™s most fascinating microscopic structures โ€“ motile cilia: t.co/OsZEpVpTfO
@cmvm-edinburghuni.bsky.social

29.07.2025 08:45 โ€” ๐Ÿ‘ 6    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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๐Ÿ“ข Excited to share our new study in Nature Communications!
We show that the A-C linker safeguards centriole architecture & controls duplication. A big congratulations to Lorรจne for this beautiful discovery, which represents 4 years of her thesis work.
www.nature.com/articles/s41...

25.07.2025 07:51 โ€” ๐Ÿ‘ 39    ๐Ÿ” 11    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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๐Ÿšจ New EMBO Practical Course!
Ultrastructure Expansion Microscopy: From Cells to Tissue ๐Ÿ”ฌ
๐Ÿ“… 20โ€“24 Apr 2026 | ๐Ÿ“ EMBL Heidelberg
Co-organised with @banterlegroup.bsky.social @gautamdey.bsky.social

๐Ÿ’ก Register your interest to get notified when registration opens:

๐Ÿ”— www.embl.org/about/info/c...

21.07.2025 09:07 โ€” ๐Ÿ‘ 59    ๐Ÿ” 29    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2

May Tโ€s light, love and laughter stay strong in you- a true force of natureโ€ฆ sending hugs to you and yours.

23.07.2025 20:52 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Oscar The Grouch & Stephen Colbert Sing 'Things Are Going To Get Better'
YouTube video by The Late Show with Stephen Colbert Oscar The Grouch & Stephen Colbert Sing 'Things Are Going To Get Better'

youtu.be/2ZoFvUgiY7g

23.07.2025 20:19 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Multi-million project to โ€˜crack the codeโ€™ of cilia โ€“ tiny structures with big impact on human health An international team of researchers, led by the University of Exeter, have been awarded a Wellcome Discovery Award grant of almost ยฃ5 million to investigate one of the bodyโ€™s most fascinating microsc...

Excited to share that we have received significant funding from the @wellcometrust.bsky.social for a new interdisciplinary consortium project on #cilia coordination and function across scales and organisms! ๐ŸŽ‰๐Ÿฅ‚@lsiexeter.bsky.social

news.exeter.ac.uk/living-syste...

14.07.2025 12:25 โ€” ๐Ÿ‘ 63    ๐Ÿ” 13    ๐Ÿ’ฌ 8    ๐Ÿ“Œ 0
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Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...

10.07.2025 21:26 โ€” ๐Ÿ‘ 146    ๐Ÿ” 47    ๐Ÿ’ฌ 7    ๐Ÿ“Œ 1
mRNA 3โ€ฒUTRs chaperone intrinsically disordered regions to control protein activity More than 2,700 human mRNA 3โ€ฒUTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3โ€ฒUTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3โ€ฒUTRs, raising the possibility of functional interactions between 3โ€ฒUTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3โ€ฒUTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3โ€ฒUTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748

New paper:
More than 2700 human 3โ€ฒUTRs are highly conserved. These 3โ€ฒUTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3โ€ฒUTRs help the folding of proteins with long IDRs.

www.biorxiv.org/content/10.1...

07.07.2025 14:28 โ€” ๐Ÿ‘ 158    ๐Ÿ” 66    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 5

๐Ÿšจ Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds whatโ€™s missing: image cells ๐Ÿ”ฌ first, decode later, revealing multi-scale phenotypes for thousands of variants.๐Ÿ‘‡

1/9

07.07.2025 02:44 โ€” ๐Ÿ‘ 45    ๐Ÿ” 18    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0
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Full Professorship in Molecular Mechanisms of Disease - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12841053 Join theMax Perutz Labs as Full Professor to unravel disease mechanismsโ€”from metabolism and stress to RNA regulation, epigenetics, and immunity.

Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...

02.07.2025 07:18 โ€” ๐Ÿ‘ 35    ๐Ÿ” 29    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 2

In both roles, new recruits will be part of an interdisciplinary team that uses state-of-the-art technologies to develop transformative therapeutic targets as part of the LifeArc Centre for Rare Respiratory Diseases. Please DM to discuss opportunities further. ๐Ÿงช๐Ÿงช /fin

07.07.2025 14:54 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Second a #SeniorResearchSpecialist position developing human iPSCs to incorporate the human genetic context into disease modelling for rare respiratory diseases. ๐Ÿงช๐ŸงชInfo here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

๐Ÿ“… New deadline closes 14 July 2025 (11:59pm GMT) ๐Ÿ“… 3/4

07.07.2025 14:53 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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First a #PostDoc position responsible for developing #GenomeSurgery approaches to correct patient-modelled variants in cell-based and in vivo animal models. ๐Ÿงช๐Ÿงช Info here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

๐Ÿ“… New deadline closes 14 July 2025 (11:59pm GMT) ๐Ÿ“… 2/4

07.07.2025 14:52 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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๐Ÿ“ฃ Cilia Lab is growing ๐Ÿ“ฃ - we have 2๏ธโƒฃ open positions at @uoe-igc.bsky.social @edinburgh-uni.bsky.social for talented and motivated researchers interested in disease modelling & genetic therapies which target #RareRespiratoryDiseases at their root cause. ๐Ÿงช๐Ÿงช#ciliopathies #PrimaryCiliaryDyskinesia 1/4

07.07.2025 14:44 โ€” ๐Ÿ‘ 28    ๐Ÿ” 23    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
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SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kรผhn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.

03.07.2025 19:45 โ€” ๐Ÿ‘ 172    ๐Ÿ” 76    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 3

Sorry Jeremyโ€ฆ โ€˜eyes on the horizonโ€™ type bravado but this must be so difficult to palate.

02.07.2025 18:59 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Always- maple magicโ€ฆ

01.07.2025 20:25 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Happy Canada Day ๐Ÿ‡จ๐Ÿ‡ฆ to those who celebrate- we did beignettes a la Tim Horton for breakfast, and big BBQ this evening after a bodysurfing session. #ElbowsOut identity worth fighting forโ€ฆ

01.07.2025 19:42 โ€” ๐Ÿ‘ 10    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

Congratulations Monica- looking forward to more amazing science and great research culture under your leadership! ๐Ÿ‘๐Ÿ‘๐Ÿ‘

01.07.2025 18:25 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Curious about tagging an endogenous protein-of-interest ๐Ÿงช in vivo ๐Ÿ - have you considered tissue-specific effects on levels & function? Read on... great skeetorial from @andrewwood.bsky.social @mrcmousenetwork.bsky.social #Degrons #FluorescentProteins #ProximityProteomics

24.06.2025 09:12 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Yes, YOU can Kirsty!! ๐Ÿ‘๐Ÿ‘๐Ÿ‘ @micromotility.bsky.social @jekely.biologists.social.ap.brid.gy @azimzadeh-lab.bsky.social Laurent Kodjabachian & Eric Keaveny #UNICIL

17.06.2025 17:11 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

@cilialab is following 20 prominent accounts