George Heath

We're also building a list of links to public #AFM image datasets to help the community find, share, and re-analyse datasets more easily.

Know of any open AFM image data? Feel free to add a link it here:
george-r-heath.github.io/NanoLocz/doc...

NanoLocz 1.3 Workshop Join for a short, practical session to get the most out of NanoLocz – AFM data analysis tool.

Join a user meeting (all welcome):
eventbrite.co.uk/e/nanolocz-1...

• Wed 11 June · 09:30-10:30 BST
(10:30 CEST 🇪🇺, 14:00 IST 🇮🇳, 16:30 CST 🇨🇳, 17:30 JST 🇯🇵)

• Tues 17 June · 16:00-17:00 BST
(17:00 CEST 🇪🇺, 11:00 EDT 🇺🇸, 08:00 PDT 🇺🇸, 12:00 BRT 🇧🇷)

Squeeze more out of your AFM images with NanoLocz v1.3 💪
Download the updated version here:
github.com/George-R-Hea...

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

A structural biology compatible file format for atomic force microscopy - Nature Communications Here, the authors developed a pipeline to transform AFM data into 3D-density files for cross-methodology structural biology analysis. Combined with molecular dynamics flexible fitting, the approach yi...

What a contribution this article is to the bioAFM community. 👍👍👍
www.nature.com/articles/s41...
#AFM

A packed conference audience listens intently to a speaker who is out of shot.

The abstract submissions deadline for #mmc2025 has been extended!

Submit your abstract by *Friday 28 February* and join our impressive line-up of speakers!

rms.org.uk/resource/mmc...

@rmsearlycareer.bsky.social @bioimaginguk.bsky.social @yorkbioimaging.bsky.social @micro-au.bsky.social

A presenter gives a talk from behind a podium at mmc2023.

📢Abstract submissions deadline for #mmc2025 is *tomorrow* (14 February).

Don't miss the chance to present your work at Europe's largest #microscopy and #imaging event taking place this year!

Abstract submissions: mmc-series.org.uk/conference/a...

@rmsearlycareer.bsky.social

Life pushed to extremes: probing the mechanisms of chromosome segregation in thermophilic Archaea at University of York on FindAPhD.com PhD Project - Life pushed to extremes: probing the mechanisms of chromosome segregation in thermophilic Archaea at University of York, listed on FindAPhD.com

📢 New round of PhD studentships.
Open to applicants worldwide.

📅 Deadline 14th March
www.findaphd.com/phds/project...

#microsky #archaeasky #chromosome 🧬🧬🧬
@steve-quinn-lab.bsky.social @georgerheath.bsky.social

Join us in beautiful York, UK!

Mechanisms of RCD-1 pore formation and membrane bending - Nature Communications The mechanism of RCD-1 regulated cell death in fungal cells is unknown. Here, the authors use AFM to uncover two mechanisms by which RCD-1 proteins form pores in lipid membranes, and discover a membra...

Check out the latest work on RCD-1 from our lab:
www.nature.com/articles/s41...
Congrats to my labmates! 👏
#AFM #RCD-1

Postdoc Varun Gupta will be presenting some great AFM in the 1st session of the Linz Winter Workshop this weekend ⛷️👏

👋👋 Hi everyone! The Astbury Centre is now on Bluesky. Follow along for updates about exciting Astbury Centre science. For now, we have put together a starter pack of members of the Astbury Centre community.

15th January is the abstract deadline for the upcoming #AFMBioMed2025 in #Barcelona! New formats, events… I wouldn’t miss it—save the date #April2025!

Proud to be part of this paper published in @naturecomms.bsky.social. Using high-speed AFM, we have visualized the real-time translocation of substrate polypeptide by the single molecule of SecYEG-SecA!!!
Please check this amazing video taken by high-speed AFM!!!
www.nature.com/articles/s41...

Please share, we have #PhD opportunities for anyone interested in filming the #Biophysics of life at the nanoscale.

Full details at: heath-afm-lab.github.io/positions/

Projects based around developing and applying High-Speed Atomic Force Microscopy methods to understand molecular dynamics.

Diagram showing archaeal cells containing two chromosomes bound by proteins prior to cell division.

📢 Interested in chromosomes and microbes thriving at the edge of life?PhD project in York-UK on chromosome segregation in #Archaea.

Supervised by me, @Steve Quinn & @georgerheath.bsky.social

www.findaphd.com/phds/project...
Open to Applicants Worldwide!

📅 January 6, 2025

#microsky #archaeasky

AFM starter pack. Sorry if I missed anyone, relatively small numbers at the moment. Please share, nominate others/yourself (any career stage). I will also try to add incoming new users regularly.
go.bsky.app/MSz2t33

First attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5

Thank you

This is the NanoRacer 🏁

Hi Johannes, great list! could I be added please?

Now out in NSMB for those who missed our biorxiv back in 2023.. bacterial ESCRT-III-like #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😵‍💫 wonderful collaboration with Adai Colom’s lab and @rouxlab.bsky.social

rdcu.be/dZSPQ

George heath and Eddie Rollins selfie

Delighted to welcome @eddierollins.bsky.social to the group as a new postdoc!

Eddie brings a wealth of expertise in bioAFM and will be applying his skills to develop high-speed AFM methods to better understand protein dynamics and interactions.

Real time view of High Speed AFM data capture at 35fps. This is a 20nm x 20nm area showing an annexin V trimer rotating within a lattice. (Data from 2022)
#AFM #microscopy

NanoLocz: Image analysis platform for AFM, high-speed AFM and localization AFM https://www.biorxiv.org/content/10.1101/2023.11.23.568405v1 NanoLocz is an open-source computer program designed for high-throughput automatic processing and si

NanoLocz: Image analysis platform for AFM, high-speed AFM and localization AFM https://www.biorxiv.org/content/10.1101/2023.11.23.568405v1