Kelsey Nemec

27-10 Seattle!

Had a great time at the @keystonesymposia.bsky.social meeting for Emerging Cell Therapies this past week in Banff! It’s a tough time out there, but hearing about all these advances in science and medicine from such smart and devoted people is what keeps me going. The scenery didn’t hurt either 🤩

My second Vitanza Lab Secret Santa! So grateful to have always managed to find the very best labs with the very best people. See y’all in 2026! 🎅 🎄 ❄️

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …

📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠

tinyurl.com/3wvmm8v3

Let's be clear: no one should be taking medical advice from the man who told Americans to inject bleach.

To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.

And to the autism community: you are loved exactly as you are.

Had the best time at the 17th annual @seattlechildrens.org Run of Hope benefiting pediatric cancer research! Over half a million dollars raised, and a lovely morning spent with friends, colleagues, and families who give meaning to everything we do. A very bright day in these not so bright times 🏃‍♀️ ☀️

My favorite training question.

What a wild study! Congrats Maureen et al! I haven't read the paper yet but curious. What would happen in adults? Is the neuro:astrogenesis thing purely bc it's during development? I'm fascinated by the idea of something increasing neurogenesis & being able to use that knowledge for other purposes.

Had a great time at my first #SeattleStorm game today with fellow @seattlechildrens.org Ben Towne Center scientists and friends! #EveryoneWatchesWomensSports

Congrats to the first graduating class of Invent at Seattle Children’s Postdoctoral Scholars! We’re so proud of what you’ve accomplished as Invent Scholars and can’t wait to see how you continue to advance pediatric biomedical research.

#MedSky #BioTech

Kelsey Nemec - Run of Hope Seattle Recent federal cuts to the NIH and the projected cuts to Medicaid will devastate health care and scientific advancements for all Americans. We will likely lose a generation of young scientists given t...

Given the recent and devastating cuts to the NIH, my colleagues and I from @seattlechildrens.org are running a 5k on 9/21 to raise money for pediatric cancer research. Please consider donating, joining our team, or simply sharing this post to help raise awareness! #EndDIPG

runsignup.com/nemec

Congratulations!!

I thought this was a Magic Eye and spent an embarrassing amount of time trying to see the hidden figure before actually reading the caption of the post.

How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...

Honeymooning in New Zealand when I got the notice that the final version of my thesis paper is out! Huge thank you to the @elife.bsky.social editors and reviewers for making this the smoothest review process I’ve ever had. Give it a read! #microglia #AGS 🤓🧠

elifesciences.org/reviewed-pre...

I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!

Scientists design gene delivery systems for cells in the brain and spinal cord NIH-funded breakthrough could enable targeted therapies for many neurological disorders.

We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord.

This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators.

🧠📈 www.nih.gov/news-events/...

This is so cool. I’ve always been flabbergasted at how people are so creative with cover submissions. How do you even think of something like this?!

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

Had a great time at #SNOPeds2025 this weekend! Thanks to @neuroonc.bsky.social for putting on such a fun and informative conference, and for having it in a city that provided some much needed spring warmth ☀️ 🌴 ☺️

A baby surrounded by medical devices is being held up by someone with gloved hands. A headline reads: "Baby Is Healed With World's First Personalized Gene-Editing Treatment." Photo courtesy of Children's Hospital of Pennsylvania.

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy

Dr. Ana Cristancho

Our May featured #FacultySpotlight is Dr. Ana Cristancho, CHOP neurologist. In her Q&A, Dr. Cristancho discusses her work investigating the mechanisms underlying the long-term effects of early-life brain injuries. http://ms.spr.ly/63325SZSdd

Mario CAR Ts for Kids - Run of Hope Seattle The fact that some brain and spinal cord tumors are incurable is unacceptable. The fact that so many standard treatments have so many side effects is unacceptable. The fact that when tumors recur ther...

The #RunofHope is an annual fundraiser for the Seattle Children's #pediatriccancer & blood disorders research. Please consider joining us and/or making a donation. No amount is too small! All donations to our team will go to the Brain Tumor Research Program
runsignup.com/cartforkids

The first photo was what I posted on my Instagram story last night. 18 hours later and I’ve signed up to run a 5k. Y’all I *hate* running. But I’m doing it to raise money for our center to fund pediatric cancer research. Plz considering supporting us! 🏃‍♀️🫣⬇️

www.runofhopeseattle.org/Race/93971/D...

Thrilled that @chopresearch.bsky.social highlighted our latest work published today in @cp-immunity.bsky.social

www.chop.edu/news/preclin...

Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia Microglia and border-associated macrophages (BAMs) are critical for brain health, and their dysfunction is associated to disease. Replacing brain macr…

Very happy for having contributed to this amazing study led by Jonathan Bastos and Kia Movahedi. Super cool findings! @sotonbiosciences.bsky.social @cp-immunity.bsky.social @liambc.bsky.social

www.sciencedirect.com/science/arti...

LOL our attempt at “learning” bulk seq from google. At least we got Hawaiian pizza out of it 🍍

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes!

www.cell.com/immunity/ful...

A NEW APPROACH TO IMAGING THE BRAIN DURING EARLY-STAGE NEURODEGENERATION — GLIA or technically, Positron Emission Tomography with [ 18 F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy [See original abstract on Pubmed]

Next up is NGG graduate Evan Gallagher’s work! Current NGG student Kara McGaughey @kara-mcgaughey.bsky.social explains how he investigated the novel positron emission tomography (PET) radioligand [18F]ROStrace as a possible in vivo biomarker for Parkinson's disease. www.upennglia.com/briefs/bib-p...