Michael Glickman

Staphylococcus aureus exploits lipoic acid salvage to combat host oxidative stress Acosta et al. find that ADP-ribosylation of the lipoic acid carrier protein GcvH-L promotes Staphylococcus aureus resistance to oxidative burst and facilitates infection. ADP-ribosylation leads to a s...

Happy to share Iván’s first-author pub from the lab! www.cell.com/cell-reports...

Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday

Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...

I’m excited to announce that our paper, describing early and opposing roles for neutrophils and CD4 T cells in determining #TB lesion structure, is out at @jem.org ! Huge thanks to my lab, and the Urdahl, @michael-gerner.bsky.social, and Aitchison labs who made this possible

doi.org/10.1084/jem....

This is a genuinely huge opportunity for the right person.

We @dunnschool.bsky.social are proud not only of our discovery science to transform human health, but also of the support we offer early career fellows.

Join us, and launch your independent career!

Please share.

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...

We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology

www.nature.com/articles/s41...

Was fun to write this piece with Dina Hochhauser!

Here is a thread to explain the premises

1/

Thanks for your leadership on this @asm.org. asm.org/articles/pol...

Now Hiring - Executive Editor

❓Do you have expertise in prokaryotic molecular biology, including transcriptional regulation, metabolism, physiology, and protein–nucleic acid interactions?

➡️ If so, apply to become @narjournal.bsky.social‬'s next Executive Editor! Don't miss the opportunity: oxford.ly/4f5p57M

Odds of winning NIH grants plummet as new funding policy and spending delays bite Funding multiyear grants up front will sharply cut number of investigators receiving awards

New Science story about multi-year funding and it potential catastrophic consequences

www.science.org/content/arti...

1/n

Thanks to all collaborators, including @casanovalab.bsky.social , @lydiafinley.bsky.social, @weillcornell.bsky.social global health center, and the outstanding core facilites at @mskcancercenter.bsky.social including Ting Zhou of the MSK stem cell core.

Our results show that itaconate biology in human macs differs from mouse and that this metabolite has distinct functions in the macrophage populatons that Mtb infects during aerosol infection.

We hope this iPSC derived system will be useful for studying AM biology in diverse contexts.

2. Itaconate has distinct functions in macrophage subtypes. In AMs, there is a loss of bacterial control in irg-/-, but In blood derived human Macs, itaconate negatively regulates the Mtb induced type I interferon and TNF responses, similar to what @stallingslab.bsky.social reportedin mouse BMDMs

We made IRG1/ACOD1 deficient iPSCs via gene editing, produced different macrophage types, and examined their phenotypes with LPS and Mtb infection. Major conclusions:

1. Human Macs produce substantially less itaconate than mouse macrophages, and AMs produce even less

We then used the genetic tractability of iPSCs to derive macrophages deficient in IRG1/ACOD1, which makes the metabolite itaconate. Itaconate has complex effects in mouse macrophages. However, the human ACOD enzyme is less active than mouse:
www.pnas.org/doi/abs/10.1...

We show that these iPSC derived alveolar macrophages, which we call AM-L (like), resemble bonafide AMs at baseline and with Mtb infection, leveraging the insights of our collaborators in the Hawn lab published here:
journals.aai.org/jimmunol/art...

To faciliate human AM studies, we derived macrophage subtypes from iPSCs under distinct cytokines, including GM-CSF, which is required for development of AMs.

Alveolar macrophages (AMs) are the first cell of contact for many inhaled pathogens, including M. tuberculosis, are developmentally distinct from blood macrophages, are difficult to study in humans due to the necessity of bronchoscopy, and are not genetically tractable.

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...

Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...

A two year post-doctoral position at the BacterialGenome Plasticity Unit starting October 1st - Research

A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon
research.pasteur.fr/en/job/a-two...

Jan, I'm really sorry about this. Totally stinks. I'm sure it does not help, but same for me. 5th percentile NCI, now above the 4% payline. Extremely painful and the grant was to continue this work that we are very excited about. Hard to know how to react.
www.sciencedirect.com/science/arti...

🦠🔬🧫🧪 #Microbiology

"In TAG’s view, the suspended TB studies do not pose a substantial risk to the American public in comparison with the clear and present danger of TB, which is the world’s leading cause of death from a single infectious agent."

www.treatmentactiongroup.org/statement/tr...

Another great University of Washington opportunity!

sph.washington.edu/careers/job/...

The GBD Fellowship is designed to cultivate the next generation of health metrics scientists to tackle the world’s most pressing health challenges through innovative research and data analysis.

🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children

Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702

CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...

🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology The construction and high-precision fitness profiling of a C. neoformans knockout library reveals a high-resolution functional map of its genome and allowed for the identification of fungal analogs of...

In today's issue of Cell-->if you are looking for a good distraction from the news (who isn't), check it out!
www.cell.com/cell/fulltex...

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer Zhang et al. demonstrate that macropinocytosis inhibition induces myCAF-to-iCAF conversion through a metabolically stressed, MEK-ERK-dependent intermediate state. This CAF plasticity remodels the pancreatic tumor microenvironment and improves responses to immunotherapy and chemotherapy, supporting macropinocytosis inhibition as a promising approach for combination treatment strategies in pancreatic cancer.

Online Now: Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

I wish I knew our destination at this point, let me know if you figure it out.