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Xantha Karp

@xanthakarp.bsky.social

C. elegans geneticist, how diapause affects development, microRNA, equity in STEM, professor at Central Michigan University, she/her/hers. https://karplab.org https://orcid.org/0000-0001-6602-5583

1,523 Followers  |  3,160 Following  |  70 Posts  |  Joined: 21.09.2023  |  2.0937

Latest posts by xanthakarp.bsky.social on Bluesky

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Pathway to Independence โ€“ an interview with Joaquรญn Navajas Acedo Joaquรญn Navajas Acedo is a Postdoc in the lab of Dr Alexander Schier in Biozentrum at the University of Basel, Switzerland. He is interested in how the nervous system evolves and develops at the singl...

In case you've ever wondered, I talked with @amjeve.bsky.social about science, myself, and the future of #DevBio as part of the Pathway to Independence Fellowship @biologists.bsky.social ๐Ÿงช journals.biologists.com/dev/article/...

05.08.2025 10:54 โ€” ๐Ÿ‘ 65    ๐Ÿ” 22    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 2
A man, the student, in a light blue button down shirt and a woman, the proud PI,  in a white shirt with a black and white flowered jacket and black respirator, smiling for the camera.

A man, the student, in a light blue button down shirt and a woman, the proud PI, in a white shirt with a black and white flowered jacket and black respirator, smiling for the camera.

A man on a stage in front of a title slide. Photo taken from a distance in the audience, so the backs of some heads are seen. Text on the slide โ€œdaf-16/FOXO regulates stage -specific seam cell fate in the dauer life history of Caenorhabditis elegans. Matthew J. Wirick, PhD defense seminar, July 25 2025โ€

A man on a stage in front of a title slide. Photo taken from a distance in the audience, so the backs of some heads are seen. Text on the slide โ€œdaf-16/FOXO regulates stage -specific seam cell fate in the dauer life history of Caenorhabditis elegans. Matthew J. Wirick, PhD defense seminar, July 25 2025โ€

Congratulations to Dr. Matt Wirick for successfully defending his PhD on the role of daf-16/FOXO in regulating stage-specific seam cell fate in the dauer life history of C. elegans!

04.08.2025 12:54 โ€” ๐Ÿ‘ 10    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
ORCID

Hi! Can you please add me to the science feed? My ORCiD is orcid.org/0000-0001-66... and my website is karplab.org. Iโ€™m embarrassed that I didnโ€™t realize until now I needed to make this request. Thanks for your time!

31.07.2025 20:22 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Well, none of us may ever get funded again but in the meantime, here's some new science!

Led by recent PhD Anjali Pandey w/ex-UG Maya Katz. Here we identify an asymmetric molecular mechanism that underlies symmetric context-dependent sensory plasticity in the AWC olfactory neuron pair in C. elegans

30.07.2025 00:51 โ€” ๐Ÿ‘ 47    ๐Ÿ” 16    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
Drawing of three scientists - from the NIH, EPA and NASA - standing together

Drawing of three scientists - from the NIH, EPA and NASA - standing together

This morning, NASA released the #VoyagerDeclaration. This afternoon, NIH #BethesdaDeclaration signers met w/ Jay Bhattacharya. Earlier, EPA staff were terminated for their act of resistance.

I made this in solidarity. @altnih4science.bsky.social @altnasa.bsky.social @alt-epa-workers.bsky.social

22.07.2025 01:52 โ€” ๐Ÿ‘ 338    ๐Ÿ” 88    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 7

Iโ€™m pleased to share the latest preprint from the Iyer Lab! ๐ŸŽ‰
We uncover a novel role for dynamin in regulating spindle pole assembly and PLK-1 localization during late mitosis in C. elegans embryos.
Read it here ๐Ÿ‘‰ www.biorxiv.org/cgi/content/...
#CellBiology #C_elegans #Cytokinesis
#Dynamin #PLK1

21.07.2025 23:43 โ€” ๐Ÿ‘ 18    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Over 2,000 senior staff set to leave NASA under agency push The losses could endanger the administrationโ€™s plans for landing astronauts on the moon and Mars.

ALL CAPS

THIS IS CATASTROPHIC FOR SPACE SCIENCE AND ASTROPHYSICS ...

GLOBALLY CATASTROPHIC, NOT JUST FOR AMERICANS ๐Ÿ”ญ๐Ÿงช

www.politico.com/news/2025/07...

09.07.2025 17:58 โ€” ๐Ÿ‘ 1606    ๐Ÿ” 661    ๐Ÿ’ฌ 56    ๐Ÿ“Œ 61

Every time I see conservative fearmongering about how dangerous the NYC subway is, I feel the need to defend it. I grew up in Ohio. Itโ€™s cars that are dangerous. Itโ€™s car accidents that are terrifyingly common. Iโ€™m not being dramatic when I say the subway is one of the best parts of my life now.

08.07.2025 15:07 โ€” ๐Ÿ‘ 4000    ๐Ÿ” 540    ๐Ÿ’ฌ 129    ๐Ÿ“Œ 112
Five smiling adults holding four babies are posing for a photo in front of a large window. Three babies are very small, about 2 months old. The fourth is a toddler.

Five smiling adults holding four babies are posing for a photo in front of a large window. Three babies are very small, about 2 months old. The fourth is a toddler.

Something joyful after the worm meeting. Karp lab F2s came to visit! Three of my students are parents, one with twins :)

07.07.2025 21:40 โ€” ๐Ÿ‘ 8    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
A stress-dependent postembryonic role for the core CPA factor CFIM-1 in germline integrity Post-transcriptional processing of pre-mRNAs generates a diversity of 3โ€™ UTR transcript isoforms that can vary in their function and stability. The differential enrichment of transcript isoforms has been implicated in diseases ranging from cancer to neurodevelopmental disorders. However, the post-embryonic developmental roles of the core ensemble of cleavage and polyadenylation (CPA) factors that mediate these post-transcriptional changes remain poorly characterized. Here, we report a stress- dependent role for the core CPA factor CFIM-1 in germline integrity in Caenorhabditis elegans. Total loss-of-function of cfim-1 elicits a temperature-sensitive sterile phenotype in hermaphrodites. These changes in brood size are accompanied by broad sperm, oocyte and germline morphology defects. Surveying the transcriptome of cfim-1(lf) worms, we uncover changes in transcript isoform abundance for dozens of genes with known functions related to the development and maintenance of these structures, consistent with a model in which post-transcriptional regulation of target genes via cfim- 1 is crucial to the development and maintenance of germline integrity. Our findings collectively define a novel post-embryonic role for a core CPA factor in tissue-specific development. ### Competing Interest Statement The authors have declared no competing interest. Canadian Institutes of Health Research, PJT 155928

If you are interested in alternative polyadenylation (APA) check out our latest pre-print on the role of the APA factor CFIM-1 (NUDT21) in the C. elegans germline. www.biorxiv.org/content/10.1...

07.07.2025 20:38 โ€” ๐Ÿ‘ 14    ๐Ÿ” 6    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Worm Show 2025
YouTube video by Morris Maduro Worm Show 2025

2025 Worm Show

youtu.be/HXgUZzLJ-b0?...

04.07.2025 10:18 โ€” ๐Ÿ‘ 30    ๐Ÿ” 14    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 4
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Congrats to the winners of the #Worm25 poster competition!

Thanks to all students who entered (285) โ€” such great research!

Thanks to all poster judge volunteers who judged presenters (220 postdocs and faculty!)

Given >1200 attendees, thatโ€™s a high % who participated in this competition!

03.07.2025 06:51 โ€” ๐Ÿ‘ 17    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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As itโ€™s my first time joining Worm Meeting, I was excited to participate in Worm Art show as well.
This yearโ€™s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25

27.06.2025 04:20 โ€” ๐Ÿ‘ 40    ๐Ÿ” 10    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1
"Use More OP50" (2025)
YouTube video by Kimberly K "Use More OP50" (2025)

Wanted to post a video we accidentally forgot to show at the Worm art show #worm25 from the Van Buskirk lab @cswormlab.bsky.social @baristursun.bsky.social

Hope you all enjoy!
youtu.be/7IMrOsmg5UY

02.07.2025 20:04 โ€” ๐Ÿ‘ 17    ๐Ÿ” 8    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
A group of 10 people sitting at a restaurant with menus, smiling for the camera. Current and former Greenwald lab members.

A group of 10 people sitting at a restaurant with menus, smiling for the camera. Current and former Greenwald lab members.

Five people sitting at a wooden table, outdoor restaurant seating, smiling for the camera. Current and former Ambros lab members.

Five people sitting at a wooden table, outdoor restaurant seating, smiling for the camera. Current and former Ambros lab members.

Ten people standing in front of the Mondavi Center, smiling for the camera. Victor Ambros plus current and former lab members.

Ten people standing in front of the Mondavi Center, smiling for the camera. Victor Ambros plus current and former lab members.

So much great science at #worm25. Best of all was being with the C. elegans community, including hanging out with current and former members of the Greenwald and Ambros labs, where I was lucky enough to get my training. Iโ€™m so grateful for you all.

02.07.2025 23:15 โ€” ๐Ÿ‘ 26    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Thank you both for all of your work!

02.07.2025 22:25 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Congratulations to all the #worm25 Poster Award Winners and Honorable Mentions!

02.07.2025 18:39 โ€” ๐Ÿ‘ 26    ๐Ÿ” 6    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2
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Go worms! #worm25

30.06.2025 00:57 โ€” ๐Ÿ‘ 85    ๐Ÿ” 21    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 4

I always love #worm25 CGC updates! But spread this impt reminder (*especially* in this funding climate): CREDIT THE CGC on papers!๐Ÿชฑ

Include this to keep the CGC around forever: "Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440)."

29.06.2025 03:50 โ€” ๐Ÿ‘ 44    ๐Ÿ” 13    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Hey everyone!
Come check out my talk this Sunday in the Development session. I will be presenting as Talk #38, right after the coffee break at 10:33 AM.
So bring your coffee and your curiosity!
#Worm25

27.06.2025 23:20 โ€” ๐Ÿ‘ 12    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Join our Cloud HD Video Meeting Zoom is the leader in modern enterprise cloud communications.

C. elegans enthusiasts - join me and @stern-lab.bsky.social โ€ชโ€ชfor a pre #worm25 meeting online workshop on *Monitoring inter-individual diversity across multiple levels and timescales* - Jun 26, 2025 12:30 PM Eastern Time
us06web.zoom.us/j/8544967372...

please share!

25.06.2025 08:19 โ€” ๐Ÿ‘ 6    ๐Ÿ” 12    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 2

I will be opening my new lab in September at UBC! if youโ€™re coming to #Worm25 and are looking for graduate studies or a postdoc position, letโ€™s meet! Vancouver + worms = perfect vibes. www.zoology.ubc.ca/~yeecs/labsi... Please share! ๐Ÿ™Œ

25.06.2025 13:48 โ€” ๐Ÿ‘ 48    ๐Ÿ” 25    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1

Congratulations!!

22.06.2025 22:43 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Hi #ASMicrobe folks: my students are presenting posters today:

AES09 #791: Sarah Pasqualetti describes plastic degrading microbes isolated from fish guts.

HMB 911: Sihan Bu describes changing microbiomes in huge eco/evo expt

HMB 949: Carol Vieira da Silva describes Aeromonas SLP on OMV

21.06.2025 18:22 โ€” ๐Ÿ‘ 13    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
A notebook that says Differentiation and has a picture of cilia on it

A notebook that says Differentiation and has a picture of cilia on it

Are you at #2025ICDB @socdevbio.bsky.social @isdb.bsky.social? Do you want a free pretty notebook? Please come find me and say hi! I have a bag full of them! It features a gorgeous image from a cilia paper from @jbwallingford.bsky.socialโ€™s lab! doi.org/10.1016/pj.d...

19.06.2025 18:34 โ€” ๐Ÿ‘ 20    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
Independent Validation of Transgenerational Inheritance of Learned Pathogen Avoidance in Caenorhabditis elegans

Highlighting this new paper NOT by my lab, but by Andres Vidal-Gadea's lab: doi.org/10.7554/eLif...
#Celegans - more to say on this later ๐Ÿงช

17.06.2025 18:46 โ€” ๐Ÿ‘ 40    ๐Ÿ” 17    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1
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Judge rules against NIH grant cuts โ€” and calls them discriminatory The decision means that the US biomedical agency has to restore funding to hundreds of research projects, but the government will likely appeal.

After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech.

I've cleaned up my notes โ€” here are his remarks in full. ๐Ÿงต

17.06.2025 13:47 โ€” ๐Ÿ‘ 413    ๐Ÿ” 197    ๐Ÿ’ฌ 9    ๐Ÿ“Œ 29

If ยง122.2 applied it would mean a USDA license would be required to move Caenorhabditis elegans across state lines! And Iโ€™ve never heard of such a thing

Anyway hereโ€™s USDAโ€™s own page:

17.06.2025 14:15 โ€” ๐Ÿ‘ 30    ๐Ÿ” 6    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Congratulations! I look forward to reading it.

17.06.2025 15:47 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@xanthakarp is following 20 prominent accounts