Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
28.08.2025 18:54 β π 80 π 30 π¬ 7 π 1
academictree.org
16.04.2025 14:42 β π 4 π 0 π¬ 0 π 0
Working on Death Domain Fold proteins (CARD, Pyrin, DED, DD)? Check out our new paper for some more perspective:
www.pnas.org/doi/10.1073/pnas.2426986122
20.02.2025 18:26 β π 4 π 1 π¬ 0 π 0
Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.
06.02.2025 09:29 β π 57 π 16 π¬ 4 π 1
Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and @alanbrownhms.bsky.social
www.nature.com/articles/s41...
01.01.2025 17:20 β π 109 π 34 π¬ 4 π 2
Architecture of the 1.3 MDa complex of human UBR4 (2 x UBR4/KCMF1/CALM1). Picture shows top and side views of the cryo-EM density map and the modeled structure, colored by protein components and domains.
π xmas preprint π we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...
21.12.2024 10:46 β π 132 π 37 π¬ 3 π 4
giant e3 ligases shaking in their boots as Dan crosses another one off the list
21.12.2024 12:57 β π 14 π 3 π¬ 0 π 0
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology?
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
19.11.2024 15:08 β π 46 π 37 π¬ 0 π 1
We are still considering postdoc candidates for the post advertised below. A 2-year contract beginning in 2025 to work on protein SUMO E3 ligases and the nucleosome.
16.11.2024 06:43 β π 14 π 8 π¬ 0 π 5
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Letβs create a good community here βοΈ go.bsky.app/3VPQofn
15.11.2024 19:38 β π 49 π 48 π¬ 6 π 1
Hard to convey how positively working with Marcin will impact your science- can not recommend enough.
17.11.2024 19:22 β π 6 π 1 π¬ 1 π 0
Assistant Professor at the University of Colorado Boulder. Microbiologist. All-around nerd.
http://colorado.edu/lab/aaron-whiteley/
The Pacific Northwest Center for Cryo-EM (PNCC) is a state-of-the-art, NIH funded electron microscopy user facility. Our mission is to serve and train the scientific community to tackle the most challenging research questions using cryo-EM.
i shoot beams at things / I Really Wish I Was On Cohost Right Now / she etc / 18+
Incoming group leader @FMI, Basel
Postdoc @MPI-MG, Berlin | PhD @IMBA, Vienna
Investigating cell fate and loss in tissue dynamics
https://www.fmi.ch/research-groups/groupleader.html?group=150
CryoEM, membrane proteins and whatnot
PhD student | MRC-UofG Centre for Virus Research π¦ π΄σ §σ ’σ ³σ £σ ΄σ Ώ
E3 ligases in innate immunity
(she/her)
ποΈ Bundesministerin Eva-Maria Holzleitner
Minoritenplatz 3, 1010 Wien
Profilfoto: Kurt Prinz
www.bundeskanzleramt.gv.at/bundeskanzleramt/bundesministerin-eva-maria-holzleitner.html
Harvard Medical School, Dana Farber Cancer Institute
https://kranzuschlab.med.harvard.edu
We investigate interesting E3 mechanisms at the frontline between virus and cell, with some virology thrown in for good measure. Ub-er fun!
At the MRC-University of Glasgow Centre for Virus Research.
https://thefletcherlab.co.uk
Sir Henry Wellcome Fellow | Oxford with Ivan Ahel & Harvard with Steve Gygi
Molecular mechanisms of cysteine modifications | GlcNAc and ADP-ribose
Previously: The Francis Crick Institute/Imperial College London (postdoc), University of Dundee (PhD)
Drosophila genetic conflicts
piRNAs | transposons | genomics
Staff scientist in the Brennecke lab - Vienna
The Sampson Lab for Kidney Genomics at Boston Children's Hospital uses #genomics to discover the causes, treatments, and cures of nephrotic syndrome in children
AITHYRA is a new dynamic research institute for biomedical AI in Vienna. AITHYRA seeks to build Europeβs premier institute for AI-driven biological and medical research, uniting computer scientists, engineers, and biologists in a collaborative environment.
Group Leader @MRC_LMB /Structural Biologist/Biochemist. Amateur baker in free time #RNAworld #spliceosome #telomerase #telomeres #cryoEM #Xraycrystallography
Harvard Kidney, Urology & Hematology Training Institute
Group leader at the Hubrecht Institute, fascinated by tissue regeneration. Studies the axolotl, a vertebrate capable of regenerating entire limbs after injury, and uses the principles learnt to build 3D tissues in vitro. π³π±π¦πΉπ¬π§π―π΅
Assistant Prof and Group Leader at Max Perutz Labs, University of Vienna
