NDimmuno

This year's JEM #Immunology collection highlights recent findings in the field of B cells, CD8+ T cell stemness, priming and differentiation, CD4+ T cell heterogeneity, autoimmunity, lymphatic immunophysiology and innate immune signaling. 👉 rupress.org/jem/collecti...
#AAI2025

ARAP2 regulates responses to interferon-gamma by restricting SOCS1 https://www.biorxiv.org/content/10.1101/2025.04.28.650977v1

Review @annualreviews.bsky.social
Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases
www.annualreviews.org/content/jour...

Texas measles outbreak rises to 48 cases. It's the state's worst in nearly 30 years The ongoing measles outbreak in West Texas has doubled in size to 48 cases, mostly in children and teens, making it the state's worst in nearly 30 years.

Of course: www.statnews.com/2025/02/14/t...

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? A new study shows that some of our cells favor genes of one parent or the other and can explain a longstanding mystery of why some people with disease-causing genes experience no symptoms.

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼

Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
@cp-immunity.bsky.social
www.cell.com/immunity/ful...

Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells Both cytosolic DNA species and innate immune STING signaling are required for stressed cells to activate phagocytes.

#WeekendRead! #EveryCellisAnImmuneCell! Park, Ahn & Barber show @sciimmunology.bsky.social that DNA-damaged cells activate cGAS-STING secreting factors & induce endosomal vesicles that activate in antigen-presenting cells cGAS-STING inducing immune activation! www.science.org/doi/10.1126/...

#Immunology by First release now @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection

https://buff.ly/3DjNQ1e

By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus - Nature Reviews Rheumatology This Review provides a comprehensive update on dysregulated type I interferon production and signalling in autoinflammatory interferonopathies, monogenic systemic lupus erythematosus and conditio...

#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus

Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review

bit.ly/4gLCpOx

This is so creepy and hilarious!

Now online - research briefing from @inflammasomelab.bsky.social Mercedes Monteleone on our recent @natimmunol.bsky.social publication on how pyroptotic cell corpses signal to dendritic cells from beyond the grave! #inflammasomes #pyroptosis #CellDeath #CLEC9A
Link: rdcu.be/d30EL

Interesting read. I wonder if we see more Mtb infections or more severe/disseminated infections in patients with monogenic interferonopathies? Esp. from Mtb endemic regions? #autoinflammation #IDsky #immunosky

1/ We are excited to share our new paper in @jexpmed.bsky.social about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem....).

CD19-CAR-T decrease autoantibody levels, thus reducing functional immune complexes that contribute to systemic sclerosis pathogenesis via activation of FcγRIIIA+ NK cells
doi.org/10.1186/s130...

ImmunoTea Episode 24 - Innate Immunity and Immunometabolism ImmunoTea: Your Immunology Podcast · Episode

Had great fun talking all things immunological to Lara and Vyanka on their ImmunoTea Podcast.

open.spotify.com/episode/2YqS...

There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...

Very cool story! A good example of how chasing the weird thing you see in sequencing data can lead to exciting new discoveries.
#RNASky #RNABiology #ImmunoSky

This sounds like science fiction!

A starter pack for anyone interested in #autoinflammation and #autoinflammatory diseases.

Please let me know if you’d like to be added.

go.bsky.app/5M6obrp

I'd like to be added! 🙋🏻‍♀️

A lipid made by tumour cells reprograms immune cells Insights into how cancer cells become unresponsive to therapy.

A lipid made by tumour cells reprograms immune cells

www.nature.com/articles/d41...

this is the N&V for:

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity

www.nature.com/articles/s41...

P-stalk ribosomes act as master regulators of cytokine-mediated processes Cytokines remodel the ribosome to incorporate the P-stalk, therefore altering the translation of mRNAs involved in cytokine responses.

So cytokines orchestrate cellular rewiring to regulate translational processes like epigenetic markers regulate transcription. Biology is so intricate!

www.cell.com/cell/fulltex...

Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...

Immunologists, time to embrace your inner neuroscientist 🧠🧪

Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology

www.nature.com/articles/s41...

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

#paperoftheweek

F-actin-rich filopodia crown pyroptotic corpses and bind to DNGR-1, to activate dendritic cells & drive immunity! 🦠

Huge congrats @inflammasomelab.bsky.social & all co-authors 👏🏻

@natimmunol.bsky.social

www.nature.com/articles/s41...

A starter pack for PhD students and Postdocs in Immunology to connect 🔽

Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!

#ImmunoSky 🧪

go.bsky.app/RABVXY4

Hello! Please add me, I'm a PhD student from India studying rare genetic disorders that cause inflammation

Done!

We've made a starter pack to bring together individuals working on primary immunodeficiency and immune dysregulation (a.k.a. Inborn errors of immunity).

Our community is slowly growing here! Let me know if you want to be added. And do tag profiles I've missed!

#PID #IEI

go.bsky.app/3D5Ew75