Doug Dyer

FindAPhD : MRC CoRE in Exposome Immunology at The University of Manchester Apply for a PhD: MRC CoRE in Exposome Immunology at The University of Manchester

PhD opportunities at our new Manchester-Oxford MRC Core - come and join us 🧠

www.findaphd.com/phds/program... [findaphd.com]

Become part of our new MRC Centre, working across Manchester and Oxford to solve a major challenge of our time - how does the immune system become dysregulated by environmental exposures to cause chronic disease.
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social

⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?

Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk

Tested by @ycharos.bsky.social & @oga-community.bsky.social

REGISTRATION FOR THE 2026 PROTEOGLYCANS GRS + GRC IS NOW OPEN! 🦠 (….and there’s a discount 😍)

Join us next summer for the GRS on Proteoglycans! We’re so excited to welcome our early career researchers that we’re giving the first 20 sign-ups a bursary towards their travel 🧵⬇️

The populist right wants to remake the UK in the image of Dubai. We should all be careful what they wish for | Jonathan Liew Politicians and influencers eulogise the emirate as a place of cleanliness, convenience and low crime. The truth is far darker, says Guardian columnist Jonathan Liew

The populist right wants to remake the UK in the image of Dubai. We should all be careful what they wish for | Jonathan Liew

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

We now have a very exciting technician post advertised as part of our long term Wellcome Trust funded team investigating the role of the glycocalyx during CNS inflammation. Supporint the lab, developing glycan analysis and research experience www.jobs.manchester.ac.uk/Job/JobDetai...

Excellent but slightly sad to see this one out, my last contribution as a Postdoc to the Handel lab is in here, congrats to the main people on it!! More of evidence and mechanism of chemokine specificity! www.jbc.org/article/S002...

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...

Join the Dyer Lab (Dr @douglaspdyer.bsky.social) as a Research Associate in Neuro-Immunology & Extracellular Matrix Biology (ImmunoMatrix).

🔬 Focus: chemokines, glycocalyx & inflammatory disease

📍 Cutting-edge biochem, biophysics & in vivo biology

Apply now 👉 shorturl.at/jEQ6G

Great opportunity available in my PhD lab! An exciting project with a really fun and supportive team 🦠

Please get in touch if interested, always happy to discuss interests!

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

FindAPhD : MRC CoRE in Exposome Immunology at The University of Manchester Apply for a PhD: MRC CoRE in Exposome Immunology at The University of Manchester

Following on from the PDRA adverts, we are also happy to announce the MRC Core in Exposome Immunology PhD scheme, details below. Reach out with any questions
www.findaphd.com/phds/program...
www.bmh.manchester.ac.uk/study/resear...

New Postdoc position as part of the recently awarded MRC Core in Exposome Immunology, led by Jo Konkel here @lydiabeckeriii.bsky.social. Job ad and more info below:
www.jobs.manchester.ac.uk/Job/JobDetai...

www.bmh.manchester.ac.uk/research/ins...

🧵How to write and manage your first research budgets

The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

Exciting to see where it goes and make sure glycans stay at the forefront!!

It was a great day! @nabalabuic.bsky.social @douglaspdyer.bsky.social @wellcometrust.bsky.social A great chance for a discussion about how we bring together all our specialities to build a useful matrix atlas - and what that should look like. Matrix assemble!

YouTube video by Francis Crick Institute The Past, Present and Future of Immunology Research – with Caetano Reis e Sousa

My "Crash Course in …Immunology" is now posted on YouTube youtu.be/nBC9vvlTxF8. Taken from a public lecture @crick.ac.uk on history and basic concepts in immunity. Aimed at the lay public and those seeking an introductory overview.

Fundamental immunology 101: the basics of an immune response Tackling infections

I thought it might be helpful to do a more general immunology explainer which I can then build on for example when I discuss specific papers or political actions. Do let me know if its useful and other topics if so. This first one is a general one about how we tackle infections... 🧪 #ImmunoSky

Really interesting article just odd being framed in the context of London! Not everything has to be referenced like that…

New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases A groundbreaking £50M research centre at Manchester and Oxford will explore how environmental exposures, like pollution and microbes, rewire our immune system and drive chronic inflammatory diseases.

🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases.
#Exposome #ImmunoSky

sites.manchester.ac.uk/lydia-becker...

So excited to FINALLY be able to share exciting news from @lydiabeckeriii.bsky.social on our newly awarded MRC Centre of Research Excellence (MRC CoRE) in Exposome Immunology #ImmunoSky 🧪 🧵

Centre to study how exposome causes chronic inflammatory disease A new Medical Research Council (MRC) centre will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases.

Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...

Our director @rachellennon.bsky.social on how we will achieve the future aims of the centre

Celebrating the 30th anniversary of the matrix centre today!!

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

With the right link:
www.science.org/doi/10.1126/...

In our science.org/doi/10.1126/... we describe the hitherto overlooked erythroblast expression of CXCR4, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, in these cells CXCR4 localises to the nucleus and mediates alternative cell responses in maturation and triggers enucleation