Doug Dyer

Really interesting article just odd being framed in the context of London! Not everything has to be referenced like that…

New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases A groundbreaking £50M research centre at Manchester and Oxford will explore how environmental exposures, like pollution and microbes, rewire our immune system and drive chronic inflammatory diseases.

🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases.
#Exposome #ImmunoSky

sites.manchester.ac.uk/lydia-becker...

So excited to FINALLY be able to share exciting news from @lydiabeckeriii.bsky.social on our newly awarded MRC Centre of Research Excellence (MRC CoRE) in Exposome Immunology #ImmunoSky 🧪 🧵

Centre to study how exposome causes chronic inflammatory disease A new Medical Research Council (MRC) centre will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases.

Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...

Our director @rachellennon.bsky.social on how we will achieve the future aims of the centre

Celebrating the 30th anniversary of the matrix centre today!!

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

With the right link:
www.science.org/doi/10.1126/...

In our science.org/doi/10.1126/... we describe the hitherto overlooked erythroblast expression of CXCR4, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, in these cells CXCR4 localises to the nucleus and mediates alternative cell responses in maturation and triggers enucleation

Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!

Not all chemokine signaling is about cell migration!

In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation.

🔗 science.org/doi/10.1126/sc…
#chemokine #CXCR4

Leukocyte #TransEndothelialMigration #TransPericyteMigration hotspots at a glance
😍

Jaap van Buul Lab @jcellsci.bsky.social 2025
journals.biologists.com/jcs/article-...

Research Associate in Mucosal Immunology :Manchester

🚨 The Menon lab is hiring a postdoc!

Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social

Please help spread the word #ImmunoSky

www.jobs.manchester.ac.uk/Job/JobDetai...

And congratulations to Richard @lydiabeckeriii.bsky.social for winning the @britsocimm.bsky.social research excellence award!

Lysosomes play a central role in regulating ECM homeostasis by influencing intracellular and extracellular molecular turnover and degradation through their biogenesis, localization, and acidification. Lysosomal biogenesis coordinates ECM homeostasis by regulating the release of ECM-degrading enzymes, promoting autolysosome-mediated degradation, and modulating lysosomal trafficking pathways. This process affects the degradation, recycling, and assembly of ECM components. Lysosomes are equipped with motor proteins, including dynein-dynactin complexes, kinesins, and small GTPases, which facilitate their trafficking along microtubules. Lysosomal acidification is essential for the breakdown and recycling of ECM components internalized by endocytosis and exocytosis, ensuring proper ECM turnover and homeostasis.

New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders.

Learn more in this #ScienceSignaling Review: scim.ag/4kG61io

Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28 The distinct functional roles of chemokines CCL27 and CCL28 in epithelial immunity of skin and mucosal tissues, respectively, are coordinated by their shared receptor, CCR10 and the CCL28-specific rec...

Some nice work we contributed to from my time @ucsdhealthsci.bsky.social on the reasons for specificity of function between CCL27 and 28 including GAG binding, www.biorxiv.org/content/10.1...

Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency Inborn errors of immunity (IEI), as congenital chronic disorders, are often associated with neurobehavioral symptoms, traditionally considered seconda…

Beautiful paper in @cp-neuron.bsky.social from the Lodato lab demonstrating how inborn errors of immunity can directly lead to neuropathology. Mutations causing Cxcr4 hyperactivation perturb cerebellar progenitor dynamics and lead to sensorimotor defects.

www.sciencedirect.com/science/arti...

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉
authors.elsevier.com/a/1l7l75FFzL...

Our latest podcast takes a fascinating look at the life and legacy of Sir Geoffrey Jefferson, the pioneering neurosurgeon whose name inspires our centre.

Listen now! the-brain-fix.transistor.fm/episodes/who...

#TheBrainFix Podcast

Hi everyone, just a reminder that I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky 🧪

Royal Society announces £30m fund to attract global talent over next two years | Royal Society International recruitment scheme comes amid announcement of Government principles for 10-year research funding

Today we've announced the new Faraday Fellowship accelerated international route, which will grant up to £30 million in funding over the next two years to attract global talent and support the development of world-leading research groups in the UK: #RSGrants royalsociety.org/news/2025/05...

New Faraday Fellowships for international applicants moving to the UK

Up to £4 million per researcher over 5-10 years

Fast-track option for mid-career researchers looking to relocate to the UK

(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!

#ChemSky #ChemBio

www.findaphd.com/phds/project...

Inhibitory TIGIT signalling is dependent on T cell receptor activation TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

It doesn't happen very often that you receive an award on the same day as your mentor. Congratulations to Peter Seeberger on winning the @rsc.org Khorana Award #glycotime! And I am very thankful to the amazing lab members, colleagues and mentors that led to winning the Norman Heatley Award!

Thanks Jo!

Cool - ever multitalented endothelial cells!

Well done!

Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky

As well as my own nomination, check out all of the other great candidates like Diana 👇