Arnd Roth

Episode #37 in #TheoreticalNeurosciencePodcast: On reproducibility of modeling and 10 years with the Potjans-Diesmann network model - with Hans Ekkehard Plesser

theoreticalneuroscience.no/thn37

How can replication crises be avoided in computational neuroscience?

Sensory expectations shape neural population dynamics in motor circuits Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...

Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...

I don't often cite The Spectator, but this is quite good.

For the voltage range please see the blue trace in Fig. 1h

Episode #33 in #TheoreticalNeurosciencePodcast: On computational neurotechnology for the clinic – with Anthony Burkitt, Nada Yousif and Esra Neufeld

theoreticalneuroscience.no/thn33

I hosted a panel debate on the topic at CNS2025 in Florence in July. @cnsorg.bsky.social

All-optical voltage interrogation for probing synaptic plasticity in vivo - Nature Communications Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

Using a new genetically-encoded voltage indicator in an all-optical approach to measure synaptic plasticity in awake behaving mice. Great work by @jacquescarolan.bsky.social and colleagues. Check out www.nature.com/articles/s41...

A real-time all-optical interface for dynamic perturbation of neural activity during behavior Zhang et al. develop a system that reads activity from individual neurons in real time and uses holographic light patterns to control specific neurons in mice, enabling automated, all-optical experime...

Check this out if you're interested in causal neuroscience and/or brain-machine interfaces www.cell.com/cell-reports...

Episode #32 in #TheoreticalNeurosciencePodcast: On IIT and adversarial testing of consciousness theories – with Christof Koch

theoreticalneuroscience.no/thn32

Christof, a developer of the IIT theory for consciousness, explains IIT and recent testing against the GNWT theory.

Want to collaborate with the International Brain Laboratory on your own project? We have funding to work with groups anywhere in the world to do new large-scale projects and we are looking for new partners! Learn more and apply: www.internationalbrainlab.com/ibl-core-apply

X Latin American School on Computational Neuroscience – LASCON 2026
University of São Paulo, Brazil
January 5-30, 2026
Application Deadline: October 4, 2025
sisne.org/en/lascon-x/

Workshop 2025 About the workshop This workshop will cover array tomography (AT) technology with a focus on “simple and affordable” workflows based on serial ultramicrotomy and imaging. The practicals include...

Our 2nd Array Tomography Workshop will be in November in Buenos Aires and there is still time to apply! Five days of hands-on learning, discussions and talks + gorgeous electron microscopy and immunofluorescence. Focus on simple and affordable workflows.
www.arraytomography.org/workshop-202...

A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently.

Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...

Log-Normal Multiplicative Dynamics for Stable Low-Precision Training of Large Networks Studies in neuroscience have shown that biological synapses follow a log-normal distribution whose transitioning can be explained by noisy multiplicative dynamics. Biological networks can function sta...

Together with @repromancer.bsky.social, I have been musing for a while that the exponentiated gradient algorithm we've advocated for comp neuro would work well with low-precision ANNs.

This group got it working!

arxiv.org/abs/2506.17768

May be a great way to reduce AI energy use!!!

#MLSky 🧪

Episode #29 in #TheoreticalNeurosciencePodcast: On the philosophy of simplification in computational neuroscience - with Mazviita Chirimuuta and Terrence Sejnowski

theoreticalneuroscience.no/thn29

What are the pitfalls when simplifying? Panel debate at FENS meeting in Oslo. @fens.org

Graphs showing 25 years of budgets for the National Institute of Health, NASA, and the NSF. In all cases, the proposed budget for next year is far, far below any year of the previous quarter century.

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.

Vesicle cycle model reveals inner workings of brain synapse Advanced modeling system sheds new light on the synaptic vesicle cycle, essential in human brain function.

How do we think, feel, remember, or move? 🧠 Collaborating with @unigoettingen.bsky.social , @deschutteroist.bsky.social models the vesicle cycle, a driving force behind neurotransmission, to reveal more about how our brains work.

For more details 👉 www.oist.jp/news-center/...

Frontiers | Does neural computation feel like something? Artificial neural networks are becoming more advanced and human-like in detail and behavior. The notion that machines mimicking human brain computations migh...

Does neural computation feel like something? In our new paper, we explore a paradox: if you replay all the neural activity of a brain—every spike, every synapse—does it recreate conscious experience?
🧠 doi.org/10.3389/fnin...

Episode #28 in #TheoreticalNeurosciencePodcast: On whole-cell modeling of bacteria – with Markus Covert

theoreticalneuroscience.no/thn28

In 2020 a model of E. coli with 10000 equations and 19000 parameters was presented by the guest.
How are such models made?

Delighted to join the Royal Society of London for Improving Natural Knowledge! It's been in the news since 1660, and more so lately. Grateful to all my collaborators over the years.

This is completely false. Even the largest university endowment cannot sustain a large-scale scientific research enterprise.

In my 25 years at Princeton, the most monumental fund drive for research raised a total of $325M. Federal research here costs $200M per year, every year.

Check out our latest profile! Dr. Eve Marder studies the stability and flexibility of neural circuit function. Follow the link below to learn more!

www.storiesofwin.org/profiles/202...

#StoriesofWiN #WomenInNeuroscience #WomenInNeuro

"Science is an investment.

We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world."

— President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷

#preprint:

We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography.

doi.org/10.1101/2025...

@yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social
@crick.ac.uk @esrf.fr

Linking function and structure at scale with X-rays - and several times over. Massive congratulations to the team ‪@yuxinzhang.bsky.social‬, @carlesbosch.bsky.social, @apacureanu.bsky.social @esrf.fr, @crick.ac.uk and all our collaborators.

Episode #27 in #TheoreticalNeurosciencePodcast: On construction and clinical use of multipurpose neuron models – with Etay Hay

theoreticalneuroscience.no/thn27

How are multipurpose neuron models made and used to explore differences between healthy and depressed brains?

"Science and peace will triumph over ignorance and war" - Pasteur

Nice mood boost etched into marble at the Mellon Institute in Pittsburgh. Seen yesterday at the moving, inspiring celebration of Carl Olson's life and career.

Super happy that our papers #2 and #3 from our 3-person lab just went online on bioRxiv! First large-scale 3D EM dataset from mouse hippocampus CA1 www.biorxiv.org/content/10.1... - check out the beautiful data on webknossos wklink.org/7023 ! …

Check out: physics-based modelling of locomotion in Drosophila

Both scary and exciting