Mike Murphy

Congrats to Patrick Cardwell on his paper that covers his PhD work - another great collaboration with the Richard Hartley lab.

doi.org/10.1016/j.ej...

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy - Nature Cardiovascular Research Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.

Congrats to Dunja on her latest paper just out in Nature Cardiovascular Research!
doi.org/10.1038/s441...

Mitochondria Signaling in Physiology and Disease | Keystone Symposia Join us at the Keystone Symposia on Mitochondria Signaling in Physiology and Disease, February 2026, in Keystone, with field leaders!

At Keystone enjoying some mitochondrial science and catching up with friends

www.keystonesymposia.org/conferences/...

Funding?

I'm a simple academic, so I'll have to await someone smart to explain to me how "pausing" MRC and BBSRC funding is the action of a biomedical science superpower...?

Congrats to Jan whose new paper on persulfide measurement is is out now in Nature Comms

Christmas in the lab....

Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia - Nature Cardiovascular Research Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...

Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.

doi.org/10.1038/s441...

Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models - Nature Communications Atherosclerosis is the leading cause of death worldwide. Here, the authors show that defective vascular smooth muscle cell tafazzin promotes mitochondrial dysfunction and atherosclerosis, highlighting...

Congrats to Emma Yu on her new paper on Tafazzin!
doi.org/10.1038/s414...

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...

Pleased to be a small part of a recent paper led by Thiru Kanneganti at St Judes
www.cell.com/cell/fulltex...

Congrats to Kath Hammond who was awarded a short talk prize at the recent WT "Mitochondrial medicine: therapeutic development" meeting at Hinxton.

Excited to share that at the annual MRC MBU symposium I was awarded best poster prize for my PhD project on Succinate Metabolism in Cardiac Ischemia/ Reperfusion Injury! Thanks to my lab, collaborators, and my PI Mike Murphy. @mitoredox.bsky.social

Understanding and slowing transverse tubule loss in heart failure at University of Bristol on FindAPhD.com PhD Project - Understanding and slowing transverse tubule loss in heart failure at University of Bristol, listed on FindAPhD.com

Drs Cherrie Kong and Stephen Harmer (University of Bristol) are offering a fully funded PhD project, "
For information and to apply: www.findaphd.com/phds/project....
For information including application preparation: cherrie.kong@bristol.ac.uk
Application deadline: 15 December 2025

Burger Lab @ UTSW The Burger Lab Defining the metabolite protein regulome

Congrats to Nils Burger who is just starting his lab at UTSW in Texas! Any prospective PhD students or post-docs should get in touch with Nils.

www.nils-burger-lab.com

In Toronto today giving a seminar at the Sick Kids Research Institute on "Mitochondria in Ischemia-Reperfusion Injury: From Basic Science to Potential Therapies"
Great to catch up with previous lab member now in Toronto - Thomas Hurd, Ellen Robb and Anna Dare.

Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke AbstractAims. Ischemic stroke is increasingly treated by mechanical thrombectomy (MT) with the more rapid and complete reperfusion of the ischemic tissue,

Great to see this paper out - another Krieg/Murphy collaboration - and congratulations to Jordan Lee who did most of the work!

academic.oup.com/cardiovascre...

Great to see Hiran Prag setting up his lab at the University of Manchester - I'm expecting great things!

personalpages.manchester.ac.uk/staff/hiran....

Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease | NEJM Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc...

It was wonderful to see the NEJM paper today about healthy babies born free of mtDNA disease following mitochondrial donation. Built on decades of work led by Doug Turnbull and his team in Newcastle.

www.nejm.org/doi/full/10....

It was a great pleasure to attend last week Professor Dunja Aksentijevic's inaugural Professorial Lecture at Queen Mary, University of London. Dunja, it's just the start!

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Congrats to Helena Cocheme @cochemelab.bsky.social on her paper on redox regulation of autophagy in Drosophila.
doi.org/10.1038/s414...

Good day yesterday at the William Harvey Research Institute Research Day where I was honoured to receive the Derek Willoughby Medal and give a lecture. Great hospitality from Dunja Aksentijevic and Sir Mark Caulfield.

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis - Nature Communications Clonal hematopoiesis is driven by the selective advantage of mutant hematopoietic stem cells. Here, authors discover that elevated mitochondrial activity is a targetable mechanism by which mutant hema...

doi.org/10.1038/s414...

Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs - Nature Dnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal h...

doi.org/10.1038/s415...

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis - Nature Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid le...

Series of interesting papers showing that haematopoietic stem cells can undergo damaging clonal haematopoiesis when they acquire mutations that enhance mitochondrial respiration - opening the way to using metformin - and my beloved MitoQ - to prevent this transition.

doi.org/10.1038/s415...

Congrats to Dunja Aksienijevic on her latest paper!

By the Atlantic in Galway at the SFRRI meeting - catching up with old friends and new.

www.sfrrgalway2025.com

Shows convincingly that that obesity increases mitochondrial ROS by RET in the liver in vivo to drive insulin resistance. This is proposed to be due to defects in CoQ biosynthesis - some fascinating findings here that will take time to explore by the community.

CoQ imbalance drives reverse electron transport to disrupt liver metabolism - Nature Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty liver dis...

Congrats to Renata Goncalves who led a study in Gokhan Hotamisligil's lab that has just come out in Nature - ably assisted by Jillian Riveros!

www.nature.com/articles/s41...

Congratulations to Abigail Giles who was awarded the "The Richard J. Bing Award for Young Investigators" at the recent World Congress of the International Society For Heart Research in Japan.

Well done Abigail!

Congratulations to @clarebryant.bsky.social on her election to the Academy of Medical Sciences!

Loss of RET-ROS at complex I induces diastolic dysfunction in mice that is reversed by aerobic exercise | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Socie... Central to the development of heart failure with preserved ejection fraction (HFpEF) is the redox disruption of metabolic processes, however, the underlying mechanisms are not fully understood. This s...

Congrats to Ana Vujic on her latest paper!

journals.physiology.org/doi/abs/10.1...