Matthia Karreman

Cancer cells hijack neurons to promote their growth. Here (and how) neurons form pseudo-synapses to promote pancreatic cancer's growth cell.com/cancer-cell/...

Functional synapses between neurons and small cell lung cancer - Nature Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

and last but not least two cancer neuroscience papers on small cell lung cancer. 1. www.nature.com/articles/s41...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

2. www.nature.com/articles/s41...

Wow congratulations, Mahak 🎊 , this is so well deserved !!!

Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present d...

Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨

How do #metastases survive (and thrive!) in the #brain microenvironment?

In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠

Shameless self promotion of our new paper. So very excited to share our new work uncovering coupling of glutamate receptors ⚡️and RTKs to enable growth of low-grade gliomas 🧠 @gutmannlab.bsky.social @washuneurology.bsky.social

How can we reawaken the body’s own anti-viral defenses to fight brain cancer?

Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏

#BrainTIME 🧠🦠🧪
🧵

www.sciencedirect.com/science/arti...

Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do In this comprehensive review, Karreman & Winkler explore how neural influences on the brain’s metastatic process govern brain tropism, colonization, and growth. Conversely, metastatic cancer has disti...

A Review by Frank Winkler & @matthiakarreman.bsky.social on how neural-cancer interactions shape metastasis and tumor evolution
www.cell.com/neuron/fullt...

Very much looking forward to this meeting!
Thank you for the invite to present our work here 🔬🐁🧠

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

HER3-targeted patritumab deruxtecan showed efficacy in leptomeningeal metastases from solid tumors in the Phase II TUXEDO-3 trial
📉 65% 3-month survival
🧬 Activity in intracranial lesions
🔷 From Matthias Preusser, MD, et al
🔗 ascopost.com/news/july-20...

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis

https://go.nature.com/46c474I

‼️Good news! Deadline for late breaking abstract submission extended until July 1, 2025! Don't miss this opportunity to present your very latest reasearch breakthrough to the #NeuroOncology community at #EANO2025. Submit your abstract👉https://eano.eu/eano2025/abstracts/ #btsm #braintumor

We’re so excited for the
Cancer Neuroscience EACR conference!
📍Bilbao, Spain
📅 14-16 Oct 2025

‼️Upcoming abstract and travelgrant deadline *June 30th* ‼️

Looking forward to seeing many of you there! 🧠🔬

#cancerneuroscience @helloeacr.bsky.social #neuroscience #cancer

Submit your abstract here 👇

Hirntumor-Netzwerk erklärt Rückkehr von Krebs – Brain Prize für Neurologe Frank Winkler Hirn- und Krebszellen vernetzen sich wie ein Hirn im Hirn – das erklärt Rückfälle bei Tumoren. Für diese Forschung wird Frank Winkler ausgezeichnet.

Herzlichen Glückwunsch an Frank Winkler! @winklerlab.bsky.social
www.3sat.de/wissen/nano/...

Fishing for melanoma metastasis-initiating cells in lymph nodes Nature Cancer - The complex nature of metastasis-initiating cells (MICs) has long hindered our understanding of how cancer spreads and how to prevent it. A study now identifies a potential MIC...

rdcu.be/emi9N
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention

This was a great meeting, inspiring, informative and with a lot of opportunity to network and catch up!
Thanks to all contributors, participants and especially to the organizers 🤩

The second day of the UNITE conference. Today there will also be a contribution from a patient on the book “Alles gut? Alles gut.” by Marlene Assmann. www.jacobystuart.de/buecher-von-...

Pictures from the discussions and presentations at the meeting

What an inspiring #HertieNetwork Symposium in Mannheim on April 10–11! A big thank you to the organizers and the amazing hosting team for two days full of insightful discussions and excellent scientific presentations! #ExcellenceInClinicalNeuroscience

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of cellular properties and multimodal analysis of brain tissue.

Nature research paper: Light-microscopy-based connectomic reconstruction of mammalian brain tissue

https://go.nature.com/3YCLkuZ

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

Thanks to expansion microscopy, clever labeling, and modern segmentation approaches, doing connectomics with #light #microscopy has become feasible - huge congratulations Mojtaba & the Danzl lab at @istaresearch.bsky.social !
www.nature.com/articles/s41...

🚨 Postdoc position open!
Join our organoid engineering team in Heidelberg to advance disease modeling & drug testing in cancer & brain disorders using AI, single-cell tech & assembloids.
🧠 5 yrs funding (CZS)
🌐 Apply: bit.ly/heidelberg-o...
#Postdoc #Organoids #Neuroscience

Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥

We just published a study diving into this question ⏬

Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉

🧵 1/

@cp-cellreports.bsky.social

www.cell.com/cell-reports...

Congratulations @lukasbunse.bsky.social , extremely well deserved indeed!!!

🚨iGluSnFR4 is finally out!🚨🧪

We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️

www.biorxiv.org/content/10.1...

🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX

#Neuroscience

Cancer research needs neuroscience and neuroscientists - Nature Neuroscience The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors gro...

#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler.
www.nature.com/articles/s41...

How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪

Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻

🧵

@cp-immunity.bsky.social

www.cell.com/immunity/ful...

It was my pleasure to write a Preview of the paper www.sciencedirect.com/science/arti... together with @venkataramanilab.bsky.social !

🧠 #cancerneuroscience #glioblastoma

The preview is now online @cp-neuron.bsky.social 👇

Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find distinct vascular alterations in IDH mutant gliomas, IDH WT…

Online now: Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors