Matthia Karreman

📢 Registration (free!) for the NCI webinar series 'Fueling Cancer Progression by the Nervous System' is open!

🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis

📅 6 exciting topics are covered by leaders in the field 💡!

Great presentation @melinamueller.bsky.social ! It is a joy to work with you 🤩

Thank you for the amazing #CancerNeuroscience conference @helloeacr.bsky.social!
We had a great time in Bilbao @winklerlab.bsky.social🧠.

Very much looking forward to presenting our work on the #cancerneuroscience of #brainmetastasis in session OS10 later today #EANO2025 !

#preclinical #NeuroOncology

We want to say a huge thank you to all who attended and helped organise Cancer Neuroscience this week in Bilbao 🎉

The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...

Fabulous work, @dirkchoffmann.bsky.social !! Let’s celebrate soon!

Congratulations 🎉 @nilshebach.bsky.social !! Fantastic work 🥳

Congratulations again @danielazorin.bsky.social !! So proud of you and so happy to be a (small) part of this work!

My main PhD project is out in #CancerDiscovery @theaacr.bsky.social

We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.

Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!

A new step towards targeting #tumornetworks in #glioblastoma !

Very happy to have made a small contribution to this exciting work led by @danielazorin.bsky.social and @dirkchoffmann.bsky.social 💐

#cancerneuroscience #GBM #braintumors 🧠

For a #Bluetorial see 👇

How to disconnect therapy-resistant tumor networks in glioblastoma?

In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...

Cancer cells hijack neurons to promote their growth. Here (and how) neurons form pseudo-synapses to promote pancreatic cancer's growth cell.com/cancer-cell/...

Functional synapses between neurons and small cell lung cancer - Nature Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

and last but not least two cancer neuroscience papers on small cell lung cancer. 1. www.nature.com/articles/s41...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

2. www.nature.com/articles/s41...

Wow congratulations, Mahak 🎊 , this is so well deserved !!!

Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present d...

Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨

How do #metastases survive (and thrive!) in the #brain microenvironment?

In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠

Shameless self promotion of our new paper. So very excited to share our new work uncovering coupling of glutamate receptors ⚡️and RTKs to enable growth of low-grade gliomas 🧠 @gutmannlab.bsky.social @washuneurology.bsky.social

How can we reawaken the body’s own anti-viral defenses to fight brain cancer?

Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏

#BrainTIME 🧠🦠🧪
🧵

www.sciencedirect.com/science/arti...

Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do In this comprehensive review, Karreman & Winkler explore how neural influences on the brain’s metastatic process govern brain tropism, colonization, and growth. Conversely, metastatic cancer has disti...

A Review by Frank Winkler & @matthiakarreman.bsky.social on how neural-cancer interactions shape metastasis and tumor evolution
www.cell.com/neuron/fullt...

Very much looking forward to this meeting!
Thank you for the invite to present our work here 🔬🐁🧠

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

HER3-targeted patritumab deruxtecan showed efficacy in leptomeningeal metastases from solid tumors in the Phase II TUXEDO-3 trial
📉 65% 3-month survival
🧬 Activity in intracranial lesions
🔷 From Matthias Preusser, MD, et al
🔗 ascopost.com/news/july-20...

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis

https://go.nature.com/46c474I

‼️Good news! Deadline for late breaking abstract submission extended until July 1, 2025! Don't miss this opportunity to present your very latest reasearch breakthrough to the #NeuroOncology community at #EANO2025. Submit your abstract👉https://eano.eu/eano2025/abstracts/ #btsm #braintumor

We’re so excited for the
Cancer Neuroscience EACR conference!
📍Bilbao, Spain
📅 14-16 Oct 2025

‼️Upcoming abstract and travelgrant deadline *June 30th* ‼️

Looking forward to seeing many of you there! 🧠🔬

#cancerneuroscience @helloeacr.bsky.social #neuroscience #cancer

Submit your abstract here 👇

Hirntumor-Netzwerk erklärt Rückkehr von Krebs – Brain Prize für Neurologe Frank Winkler Hirn- und Krebszellen vernetzen sich wie ein Hirn im Hirn – das erklärt Rückfälle bei Tumoren. Für diese Forschung wird Frank Winkler ausgezeichnet.

Herzlichen Glückwunsch an Frank Winkler! @winklerlab.bsky.social
www.3sat.de/wissen/nano/...

Fishing for melanoma metastasis-initiating cells in lymph nodes Nature Cancer - The complex nature of metastasis-initiating cells (MICs) has long hindered our understanding of how cancer spreads and how to prevent it. A study now identifies a potential MIC...

rdcu.be/emi9N
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention

This was a great meeting, inspiring, informative and with a lot of opportunity to network and catch up!
Thanks to all contributors, participants and especially to the organizers 🤩