MCGalan Lab

Many congratulations to @jenniferjohns01 @BCS_CDT @BristolChem for winning the Biosynth best oral presentation at the RSC Carbohydrate Winter meeting 2025 www.rsc.org/events/detai... 🥳

Really excited to be here in Turku, Finland at the 34th BioCity symposium biocityturku.fi/biocity-sympos… to showcase our latest synthetic tools as bacterial diagnostic tools @BristolChem

Bridged Azobenzene Exhibits Fully Reversible Photocontrolled Binding to a G-Quadruplex DNA/Duplex Junction The ability to selectively control DNA conformation using light as an external stimulus offers unique opportunities to control specific DNA sequences in biological settings and to develop nucleotide-b...

Check out our latest work with @JaviRamSor @AdrianMulholla1 @dengbowen9373 @chemistry_mike @DoudouLu319, Sofia Oliveira and others @bristolchem on a new bridged azobenzene with reversible photocontrolled binding to a G-Quadruplex DNA/Duplex junction. pubs.acs.org/doi/10.1021/...

Enhorabuena!

Want to learn about sigma hole donor XB and ChB catalysis in oligosaccharide synthesis, have a look at our recent Focus Review.
@MukulMahanti @BristolChem

sciencedirect.com/science/arti...

Carbon Dots as an Emergent Class of Sustainable Antifungal Agents Carbon-based functional nanomaterials with distinct photoluminescent properties have gained significant attention for their diverse applications in bioimaging, biomedicine, and antimicrobial treatment...

Carbon Dots as an Emergent Class of Sustainable Antifungal Agents | ACS Nano pubs.acs.org/doi/10.1021/...

Congratulations to @DoudouLu319 from our group @Bristolchem on winning one of the Poster Prizes at the recent RSC Nucleic Acids Forum 2025 - #G4photocontrol 🙌

Congratulations to all the prize winners from the Nucleic Acids Forum 2025! An amazing selection of talks and posters to choose from! Thank you to our prize sponsors Chemgenes and RSC Chemical Biology!
@rscchembio.rsc.org
@mikeboothlab.bsky.social

As promised, postdoc positions at BristolUni.bsky.social available in homogeneous catalysis and computational chemistry exploring the replacement of palladium catalysts by Earth-Abundant Metals: www.bristol.ac.uk/jobs/find/de...

#ChemSky #CompChemSky #ChemJobs #UKChemJobs

Great talk from @jenniferjohns01 @BCS_CDT @eurocarb22 discussing our latest results on stereoselective glycal activation.

Really happy to receive the 2025 Emil Fisher Award in Carbohydrate Chemistry @eurocarb22 @BristolChem jointly with @FlitschSabine . Looking forward to the rest of the meeting.

Really excited for the start of @eurocarb22 in Gdansk. Kicking off with a choir performance before we move to the scientific programme at the beautiful Baltic Philharmonic.

This is a follow up review article on our previous review on carbon dots as antimicrobial agents for those interested in the field www.mdpi.com/2079-4991/11...

Carbon Dots as an Emergent Class of Sustainable Antifungal Agents Carbon-based functional nanomaterials with distinct photoluminescent properties have gained significant attention for their diverse applications in bioimaging, biomedicine, and antimicrobial treatment...

Hot of the press: are you interested in Carbon Dots as an Emergent Class of Sustainable Antifungal Agents. Check out our review in | ACS Nano pubs.acs.org/doi/10.1021/...
@MattiaGhirarde2 @JaviRamSor @BristolChem

Congratulations to Dr Gurudas Chakraborty’s for a great PhD defence in Groningen with Prof Carmen Galan - my first in the Netherlands 🇳🇱 😀

It has been an absolute blast to be part of Dr Gurudas Chakraborty’s PhD defence in beautiful @univgroningen with @DrZoeWaller. Many congratulations on an excellent thesis and oral defence.🍾

Heading home now after a great week of science and outdoor activities, while meeting old and new friends. Looking forward to chairing with @SteSuch the next #GRCCarbohydrateChemistry 2027 meeting. Hope to see many of you there!

The sun is out … great start for the 2nd day at the GRC Carbohydrates meeting.

www.grc.org/carbohydrate...

It is good to be back at Holderness School

With NeuGc labelling we get 2 isomers, which we weren’t able to separate on HLPC. For MS detection purposes, this is not an issue. Thanks

Improved ESI-MS Sensitivity via an Imidazolium Tag (DAPMI-ITag) for Precise Sialic Acid Detection in Human Serum and CMAH-Null Mouse Tissues Sialic acids (Sias), consisting primarily of N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), play crucial roles in many biological processes. The detection and quantification of Sias are essential for understanding their roles in health and disease progression. Although numerous techniques have been developed to enhance the specificity and sensitivity of Sias analysis, traditional methods such as derivatization with fluorescent tags coupled with HPLC-MS analysis often suffer from low limits of detection, limiting the quantification of Sias in trace samples. Here, we introduce DAPMI, a novel imidazolium-based ITag for sensitive Sia detection. We demonstrate its utility in the detection and quantification of Sia composition in human serum, and in different tissues from CMAH (cytidine monophosphate-N-acetylneuraminic acid hydroxylase) knockout mice, using ESI-MS analysis and with a limit of detection (LOD) down to the low fmol range. The results showed that both Neu5Ac and Neu5Gc were present in varying proportions in wild-type mice and CMAH heterogeneous mice. Trace amounts of Neu5Gc were also detected in the tissues of CMAH null homogeneous mice (CMAH–/−) and in human blood serum using ESI-ToF-MS, suggesting its presence may be linked to dietary intake of Neu5Gc-containing foods, as Neu5Gc cannot be synthesized endogenously in CMAH–/– mice, and in humans. The DAPMI-ITag and the labeling technology developed in this study significantly improve the sensitivity of Sias detection compared to conventional tags such as o-phenylenediamine (OPD), and provide a new chemical tool for the exploration of Sias’ biological roles and their use as biomarkers in different human conditions.

Congratulations to the team @BristolChem and collaborators in China #Voglmeir's team & Spain @MattiaGhirarde2 for the fantastic team effort on developing a new Imidazolium Tag (DAPMI-ITag) for Precise Sialic Acid Detection in Human Serum and CMAH-Null Mouse Tissues pubs.acs.org/doi/10.1021/...

Ready for the start of #B&B2025 #Edinburgh meeting rsc.org/events/detail/… - thanks to Asier @BOOMchemistry and Marc @dynafluors for organising.

#chembio, #glycotime and #bioorganic crowd, join us tomorrow online ✨for free✨!!

Cu(I)-Catalyzed Stereoselective Glycosylation of “Electron-Deficient” Glycals An efficient and mild Cu(I)-catalyzed Michael-type conjugate addition for 2-nitro glycals to access O-, S-, and C-glycosides with high stereoselectivity is reported. Under optimized conditions, nitrog...

Great to see this out now Cu(I)-Catalyzed Stereoselective Glycosylation of “Electron-Deficient” Glycals pubs.acs.org/doi/10.1021/...
Well done @MukulMahanti @NatalieFey_NLS N. Walker and C. Sauders @BristolChem @BCS_CDT

Such a wonderful day out at Cheddar Gorge with a team of brilliant scientists and colleagues. It is good sometimes to stop and smell the flowers … and get some real Cheddar cheese 🧀😉

Carbohydrates An Important link between chemistry, biology and industries - American Chemical Society A virtual symposium of ACS Spring 2025 programmed at convenient day times of multiple regions, including the latest in organometallic chemistry and catalysis.

Congratulations to @CalumHaydon @Bristolchem @BCS_CDT on winning a Best Flash Presentation Award at the ACS Spring 2025 Digital Meeting - Carbohydrates: An Important link between chemistry, biology, and industries. www.acs.org/meetings/acs...

Carbohydrates GRC
This year's conference list has not yet met the registration goal, which is important for the continuity of this GRC.

www.grc.org/carbohydrate...

Post-doctoral available in our team at @cermav.bsky.social in protein engineering for glycosciences.

emploi.cnrs.fr/Offres/CDD/U...

Join us for exciting project aiming at developping new probes for characterizing structure and dynamics of polysaccharides in plante cell wall.

Thanks #ACSCarb division for awarding me with the ACS 2025 Melville L Wolfrom award acscarb.org/awards/wolfrom… Truly honoured to have received this recognition and celebrate with friends and colleagues

Many thanks to Richard Hartley and Andrew Sutherland for hosting my visit to Chemistry @uofglasgow.bsky.social - what great day of science discussions with fantastic colleagues.

@g4interact 2025 kicks off with @VaLePirota welcome address followed by fantastic lectures by @SaraNRichter_ lecture on G4s in disease and Carlos Gonzales @cgiba87 and Janez Plavec on G4 structure by NMR