Caroline (Lindy) Rae

Just published ! Two chapters encapsulating the idea of constrained brain energy metabolism that lies at the heart of brain vulnerability in aging, development and stress. Result of a week's hard work at the Ernst Strüngmann forum.
rdcu.be/eJvXK
rdcu.be/eJv3I

Super pleased to have finally published our latest neurochemistry review on the many and varied roles of aspartate in brain.
rdcu.be/eqMHd

New paper showing a key component of the glutamate-glutamine cycle. NTT4 (SLC6A17) supplies Gln for the presynaptic production of Glu. Needed to sustain rapid ongoing excitatory synaptic transmission and has roles in memory formation and other behaviours.
doi.org/10.1016/j.pneurobio.2025.102785

Glutathione Metabolism of the Brain—The Role of Astrocytes Astrocytes supply neurons with the substrates for the synthesis of GSH (γGluCysGly). Astrocytes provide neurons with precursors for the three amino acids that are needed for GSH synthesis. The supply....

New review on glutathione and its role in astrocytes from lab of GSH guru Ralf Dringen.
doi.org/10.1111/jnc....

ISN is proud to support #SONA2025 in Marrakech! 🌴

Join us for sessions with Rosa Cossart, Ines Elbini, Elisabeth Ngo Bum, and our ISN Lunch Talk.

Visit the ISN booth to connect, learn more about the society, and grow in neurochemistry.

#WeAreNeurochemistry #neuroskyence #NeuroSky

Fantastic @neurochemistry.org sponsored talk at Society of Neuroscientists in Africa from Rosa Cossart. Detecting a body size dependent developmental switch in the GABAergic hippocampus which is disrupted in an #autism model.
#SONA2025

Enabling global image data sharing in the life sciences - Nature Methods This Perspective provides a roadmap toward globally federated open data resources for bioimaging data.

New Nature Methods paper co-authored by experts from @globalbioimaging.bsky.social highlights the need for sustained investment in open, long-term image data storage.

Read more: doi.org/10.1038/s415...

Job Opportunity at JNC!✍️

The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.

✅ Remote & flexible
✅ Support publishing
✅ Global network

🔗Apply here: bit.ly/3FAs1M6

📰 ISN News Issue 3 is here! 🧠

📊 @altmetric.com scores - What do they measure?
🏆 Rui Rodrigues(@ruisrodrigues.bsky.social) & Anna Hoffmann share insights on award -winning posters.
📉 What do p-values really tell us?

🔗 ow.ly/NH5L50V3wgs

#WeAreNeurochemistry #neuroskyence #BrainResearch

Nice! Where’s the rest of it?

Happy to have helped (skyless) Alistair Carroll publish the first paper from his PhD research. There’s more to come!

a drawing of a brain with a rainbow and a blue one ALT: a drawing of a brain with a rainbow and a blue one

Interested in how maternal stress affects the offspring’s brain? Come and do a PhD with us in beautiful Edinburgh. More info here: www.findaphd.com/phds/project...

Interesting. Seems to need relatively high levels of R-BHB.

Time to (re)join for all neurochemists!👇👇👇👇👇👇

Glad to see her in the seat!💕

Whole-brain responses to visual and auditory stimuli in anesthetized and minimally restrained awake mice using quiet zero echo time fMRI Abstract. Functional MRI (fMRI) is a flexible tool for sensory perception studies in animal models. However, animal fMRI studies are generally performed under anesthesia. Unfortunately, anesthesia aff...

This is soo cool 😎
Awake fMRI in mice.
doi.org/10.1162/imag...

Can verify that it is lovely. I gave one to an astrocyte aficionado but it was hard parting with it….

Tough but quality..

J Neurochem, Glia

l-Proline Alters Energy Metabolism in Brain Cortical Tissue Slices - Neurochemical Research L-Proline (l-Pro) is a non-essential amino acid which, in high concentrations, can cause neurological problems including seizures, although the causative mechanism for this is unclear. Here, we studie...

Just published a little paper about the role of L-Proline in brain metabolism. It stimulates mitochondrial metabolism but doesn't seem to do it by being metabolised (under the conditions studied). Yet another unsolved mystery in brain energy metabolism... Scratches head....
doi.org/10.1007/s110...

Thanks for underlining this really important support initiative @zilamartinezlozada.bsky.social
The ISN www.neurochemistry.org has support for carers sewn into its grant and travel schemes + special support for travel to the biennial meeting.
Next one is in fantastic New York city in 2025.

Sodium dysregulation may play a role in Alzheimer's disease with links to increased amyloid-dependent tau pathology, neurodegeneration, and cognitive impairment. Sodium channel subunits (SCN2B &3B) showed strongest correlation with hippocampal volume and cognitive function
doi.org/10.1111/jnc....

Latest issue of ISN News is out and available to read online. Includes advice on responding to reviewers from @drbreaky.bsky.social
www.neurochemistry.org/isn-news-02/