NicolasDSP

In French - Virginie on Swiss radio! 🎙️ She talks about our latest collab with @dudinlab.bsky.social and @gautamdey.bsky.social #UExM #ProtistsOnSky

03.11.2025 17:13 — 👍 26    🔁 4    💬 0    📌 0

CoccidiaUK 2025 registration DEADLINE FOR ABSTRACT SUBMISSION: NOVEMBER 7th Event Timing: December 8th 9am-5pm December 9th 9am-12pm Event Address: The Francis Crick Institute Questions? please email ada...

Who-cysts? OOCYSTS! That's right, it's almost time for ❄️Coccidia UK 2025❄️

Your one-stop shop (/conference) for all like-minded sporulating apicomplexan parasites! This year we're in London @crick.ac.uk, looking forward to welcoming parasitologists from across the UK. Register-
tinyurl.com/4ny5bwu2

14.10.2025 16:58 — 👍 4    🔁 3    💬 2    📌 0

Les Embiez harbour at sunrise

View from the highest point of the island

Last week I attended my first #EMBO #ParaFrap Host-Parasite Interaction meeting in Les Embiez 🇫🇷

I had an amazing time packed with great science and people 👨‍🔬👩‍🔬

Thank you to the organizers for the chance to talk about my work on Perkinsus 🦠🦪 and thank you to everyone for the support and kind words! 🥹

13.10.2025 21:46 — 👍 4    🔁 0    💬 0    📌 0

Thanks a lot for the kind words and support! 😃

06.10.2025 22:12 — 👍 1    🔁 0    💬 0    📌 0

Presentation on Perkinsus cell biology in the main auditorium at the MBL Woods Hole

MBL - Woods Hole

MBL - Woods Hole

Jetlag-fueled sunrise are the best!

Had an incredible time at the MPM 🇺🇸! It was an honor to talk about my work on Perkinsus, especially at the Marine Biological Laboratory, a perfect venue for a marine parasite 🌊🦠 So great to see such a diverse range of parasites and topics this year! Thanks to everyone for the fantastic discussions!

19.09.2025 13:53 — 👍 10    🔁 0    💬 0    📌 0

Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …

🚨 New paper out! 🚨

🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!

Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics

www.sciencedirect.com/science/arti...

18.09.2025 22:13 — 👍 3    🔁 2    💬 0    📌 0

Transfection of the free-living alga Chromera velia enables direct comparisons with its parasitic apicomplexan relative, Toxoplasma gondii https://www.biorxiv.org/content/10.1101/2025.08.26.672290v1

29.08.2025 22:30 — 👍 3    🔁 2    💬 0    📌 0

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Finally out! Did you ever wonder how a phylum with 10 core genes can make a conserved organelle? Read the paper! It's all about intrinsically disordered proteins! | PNAS www.pnas.org/doi/10.1073/...

27.08.2025 18:07 — 👍 9    🔁 6    💬 1    📌 0

Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine - Nature Communications Cryptosporidium is an important threat to public health, yet it lacks a robust genetic toolkit. Here, Watson et al. introduce a targeted CRISPR-based screening method to identify parasite genes that a...

Now available in a polished format! An important step toward accelerated functional genomics for the Cryptosporidium parasite. Brought to you by the incomparable @lucy-watson.bsky.social
www.nature.com/articles/s41...

20.08.2025 17:58 — 👍 21    🔁 10    💬 2    📌 0

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social

07.08.2025 18:12 — 👍 106    🔁 55    💬 1    📌 2

Join our crazy beautiful project of ExM Atlas !
One more position to fill, this time for a Research Technician at @embl.org in @gautamdey.bsky.social lab.

Come have fun with us !.

07.08.2025 18:22 — 👍 22    🔁 14    💬 0    📌 1

🚨 New EMBO Practical Course!
Ultrastructure Expansion Microscopy: From Cells to Tissue 🔬
📅 20–24 Apr 2026 | 📍 EMBL Heidelberg
Co-organised with @banterlegroup.bsky.social @gautamdey.bsky.social

💡 Register your interest to get notified when registration opens:

🔗 www.embl.org/about/info/c...

21.07.2025 09:07 — 👍 61    🔁 29    💬 1    📌 2

The anticipation is over, the MPM registration and abstract submission is open!!

05.06.2025 17:00 — 👍 10    🔁 4    💬 0    📌 0

Check out our dispatch on apicomplexans that infect corals!

www.sciencedirect.com/science/arti...

These parasite-like partners have lost photosynthesis but retained chlorophyll... are they friend or foe?

@currentbiology.bsky.social #protistsonsky #symbiosky #microsky #coralreefs

13.03.2025 12:11 — 👍 44    🔁 25    💬 3    📌 0

Cryptosporidium modifies intestinal microvilli through an exported virulence factor Cryptosporidium is a common intestinal infection of vertebrates and a significant threat to public health. Within the epithelial layer of the intestine, the parasite invades and replicates. Infected cells are readily detected under the microscope by the presence of elongated microvilli, particularly around the vacuole where the parasite resides. Here, we identify a family of Cryptosporidium virulence factors that are exported into the host cell during infection and localise to the microvilli. We examine the trafficking and function of the most highly expressed family member, MVP1, which appears to control the elongation of microvilli through engagement of host EBP50 and CDC42. Remarkably, this mechanism closely mirrors that of an enteropathogenic Escherichia coli virulence factor, MAP, which is also known to drive host microvilli elongation during infection. This highlights a unique instance where eukaryotic and prokaryotic virulence factors have convergently evolved to modulate host actin structures through a similar mechanism. ### Competing Interest Statement The authors have declared no competing interest.

Cryptosporidium modifies intestinal microvilli through an
exported virulence factor!! Phenomenal work from the newly DR’ed Elena Rodrigues
www.biorxiv.org/content/10.1...

26.02.2025 12:53 — 👍 29    🔁 14    💬 5    📌 1

It's transfection time for Perkinsus marinus and chesapeaki ⚡🦠🧬⚡ Hoping to have some fluorescent parasites in the coming days 🔬 So exciting!! #ProtistOnSky

24.01.2025 18:17 — 👍 5    🔁 0    💬 0    📌 0

Very nice 🤩

09.01.2025 23:18 — 👍 0    🔁 0    💬 0    📌 0

Thanks Omaya! I'm planning to do U-ExM very soon on those cells! 😁🔬

04.01.2025 13:53 — 👍 2    🔁 0    💬 1    📌 0

Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi https://www.biorxiv.org/content/10.1101/2025.01.03.631223v1

04.01.2025 12:31 — 👍 10    🔁 7    💬 0    📌 1

I haven't observed enough cells to confidently conclude about synchronicity just yet 😅. Here's a video of a sporangium where the first division appears asymmetrical. I'm unsure if this is physiological tho... It might just be cell division going wrong !

03.01.2025 19:14 — 👍 3    🔁 0    💬 1    📌 0

Discover the wonders of 𝘗𝘦𝘳𝘬𝘪𝘯𝘴𝘶𝘴 🤩 This parasitic protist undergoes rapid #CellDivision : from a single sporangium to hundreds of motile zoospores. A stunning glimpse into the speed and precision of microbial life! 🌊🔬 Stay tuned for more 𝘗𝘦𝘳𝘬𝘪𝘯𝘴𝘶𝘴 insights! #CellBiology #ProtistsOnSky

02.01.2025 16:33 — 👍 53    🔁 17    💬 2    📌 2

Cambridge colleges 🎄

22.12.2024 19:30 — 👍 1    🔁 0    💬 0    📌 0

𝘗𝘦𝘳𝘬𝘪𝘯𝘴𝘶𝘴 zoospores swimming out of their sporangium 🤩🏊‍♂️

19.12.2024 09:07 — 👍 15    🔁 0    💬 0    📌 0