Jakob Woerner

Likewise!

05.09.2025 00:51 — 👍 1    🔁 0    💬 0    📌 0

Super excited to share our work this morning in Cologne! Lots of great discussion on combining genomics and proteomics for discovery and prediction

01.09.2025 09:47 — 👍 4    🔁 0    💬 1    📌 0

Leena Peltonen School of Human Genetics in full-swing!

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30.07.2025 10:04 — 👍 56    🔁 9    💬 0    📌 6

Fair point, one is cheaper, one is generally more predictive. A key point of the work is to find where integrating genetic information might provide additional insight beyond what proteomics can show

16.07.2025 14:44 — 👍 0    🔁 0    💬 0    📌 0

And interestingly, ProRS values in the disease population are elevated even a decade before diagnosis! These scores then continue to rise up until diagnosis.

It'll be interesting to see how proteomics will continue to grow to help identify disease states and its application for precision medicine

15.07.2025 01:52 — 👍 1    🔁 0    💬 0    📌 0

While proteomic risk scores (ProRS) provide a dynamic look at a person's current health status, polygenic risk scores (PRS) can further stratify individuals by risk across a range of diseases

15.07.2025 01:40 — 👍 1    🔁 0    💬 1    📌 0

Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1

15.07.2025 01:32 — 👍 11    🔁 3    💬 2    📌 0