Bogdan Pasaniuc

Dissecting pleiotropy to gain mechanistic insights into human disease Nature Reviews Genetics - Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors...

Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ

INCEPTION Symposium 2025 - Research INCEPTION symposium 2025 - Focus on GWAS: paving the way for the future of genetics.

The INCEPTION is organizing its Annual Symposium. This year is about GWAS & beyond! We're happy to have @bpasaniuc.bsky.social, @caina89.bsky.social, Iuliana Ionita-Laza , Sriram Sankararaman, and others, who will talk about tools for understanding the genetic determinants of complex diseases

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

What we talk about when we talk about risk How embryo selection exploits our flawed intuitions about risk

I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...

You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

Text from an FAQ in Okbay et al 20222: https://www.nature.com/articles/s41588-022-01016-z a similar same statement is made in an FAQ in 2025: https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1.supplementary-material Text reads: "The results of SSGAC studies have sometimes been used by online platforms, including some companies, to predict individual outcomes. We recognize that returning individual genomic “results” can be a fun way to engage people in research and other projects and to feed or stoke their interest in genomics. But it is important that participants/users understand that these individual results are not meaningful predictions and should be regarded essentially as entertainment. Failure to make this point clear risks sowing confusion and undermining trust in genetics research"

It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ

A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵

Image of an old building in Oxford with the heading 'postdoc opportunities' and the text 'computational approaches to improve rare disease diagnosis and treatment' and 'Big Data Institute, University of Oxford'

📣 We are recruiting! Please share!!

Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺

We have two roles available 👇

🧵 1/4

We have multiple postdoc positions available in my group at NYU. Join us if you're interested in complex trait genetics and biology. More information about the lab on our website: mostafavilab.org

FIMM-EMBL Group Leaders in Molecular Medicine FIMM-EMBL Group Leaders in Molecular Medicine

We have 2-3 group leader positions opening @fimm-uh.bsky.social !!

We are looking for outstanding candidates in human genetics and precision medicine.

This time we have a focus on population health data science. E.g. AI for EHR/health data       

Generous starting package 💰

shorturl.at/FAk6n

Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025.

These things can take time and patience is key!

📢OUT TODAY @natgenet.nature.com

📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.

By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.

⬇️

www.nature.com/articles/s41...

Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1

Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!

Exploring depression treatment response by using polygenic risk scoring across diverse populations Ancestrally diverse biobanks where medication, disease, and genetics are linked provide an opportunity to understand treatment response to major depressive disorder (MDD). We developed polygenic risk ...

📣New from @bpasaniuc.bsky.social & co
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations

Rivian just reported Q1 2025 earnings:

- Second straight quarter of gross profit
- R2 still on track for early 2026
- Hands-free driving rolling out
- $1B from VW coming in June
- Deliveries revised to 40k–46k for 2025

Full details: riviantrackr.com/news/rivian-...

Inclusive Genomics to Promote Health Excellence Symposium

Two more weeks to go! Inclusive Genomics to Promote Health Excellence Symposium at @upenn.edu @penngenetics.bsky.social @pennmedcso.bsky.social!

Excited to host such an amazing lineup of speakers! Registration is free but required; see www.med.upenn.edu/ccb/

Looking forward to presenting at the Cell Symposia: Precision genomics for human health in San Diego, September 11–13, 2025. For a chance to present your research at this event, submit an abstract before May 30 here: www.cell-symposia.com/precision-ge... #CSPrecisionGen25

See you in San Diego!

Eugenics is on the rise again: human geneticists must take a stand Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.

I wrote about how we must stand and fight against the threat of eugenics.

Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent.

This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.

Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery - Nature Medicine The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonis...

🚨 New paper 🚨

Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?

🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery

www.nature.com/articles/s41...

Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm!

Submission deadline is June 8th, conference July 6-11th.

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum Nature Genetics - Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across...

Excited to see this published: rdcu.be/egHer

Common- and rare-variant genetic analyses of heart failure in >2 million individuals

🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv

“Investments in science and public health are essential for the future of rural southern states like Mississippi.”

Read about my perspectives as a Mississippian and scientist in my recent OpEd : digital.meridianstar.com/The-Meridian...

This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something.

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....

WHAMM identified as key kidney disease risk gene ft. @DhanunjayMukhi, Lakshmi Kolligundla, @TomohitoD, @andradesilvamag, @ksusztak.bsky.social (@PennKidney/ @penngenetics.bsky.social), @Hongbo919Liu (@UR_Med) & Matthew Palmer (@pennpathlabmed.bsky.social) www.cell.com/cell-reports...

Opinion | Should Human Life Be Optimized? Advances in genetic testing and artificial intelligence are changing what’s possible for those undergoing I.V.F. Are we ready for the future of fertility?

The New York Times recently had an article on IVF and embryo selection which I think buries a few important ledes about these products ...

I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...

Register for the UPennn symposium on “Inclusive Genomics to Promote Health Excellence” organized by @sarahtishkoff.bsky.social and @bpasaniuc.bsky.social at the Center for Global Genomics & Health Equity and the Center for Computational Biomedicine.
Link: upenn.co1.qualtrics.com/jfe/form/SV_...

Dr. Sarah Dry and Dr. Bogdan Pasaniuc gearing up for another path-packed day at #USCAP2025!

Join us for UCLA Pathology's events today!

Full Schedule ➨ bit.ly/4ccBkxZ

#pathology #path2path #PathSky #Boston #GIpath #Genomics @bpasaniuc.bsky.social @uscap.org

Terrific speaker line-up covering a broad spectrum of biological questions addressed through a common language made of math, statistics and computer science
#ai #computerscience #math #physics #complexsystem #evolution #machinelearning #statistics #popgen #genomics #proteomics Please re-post !