Journal of Clinical Epidemiology @jclinepi

Thanks for the brief explainer, Robin. Also added you to our @jclinepi.bsky.social authors starters pack.

31.10.2025 12:27 — 👍 2 🔁 0 💬 0 📌 0

Glad to share our full paper on why deployed clinical prediction models should not discard predicted risks in favour of thresholds with @rexwp.bsky.social and @aidybarnett.bsky.social now up on @jclinepi.bsky.social. A brief explainer (1/4):
#statsky #rstats
authors.elsevier.com/a/1m1D83BcJQ...

31.10.2025 10:49 — 👍 10 🔁 4 💬 3 📌 0

Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions Jurisdictional scans are used to inform policy by systematically comparing how different jurisdictions define problems, design policies, and implement strategies. They provide insights into policy opt...

Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

26.10.2025 19:23 — 👍 5 🔁 1 💬 0 📌 0

Applying the GREET checklist for assessing reporting of evidence-based practice educational interventions and teaching showed inter-rater discrepancies and item-level challenges This study aimed to analyze in-depth inter-rater discrepancies in GREET (Guideline for Reporting Evidence-Based Practice Educational Interventions and Teaching) item ratings between two GREET-naïve da...

Applying the GREET checklist for assessing reporting of evidence-based practice educational interventions and teaching showed inter-rater discrepancies and item-level challenges - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

26.10.2025 19:18 — 👍 3 🔁 2 💬 0 📌 0

Identifying potentially inappropriate prescribing in entire populations: Coding the STOPP-START and Beers criteria for use with large, routinely collected population health datasets Plain Language Summary: Older adults often take multiple medications, increasing the risk of harmful drug interactions or unnecessary treatments. STOPP-START and Beers criteria help doctors identify i...

Identifying potentially inappropriate prescribing in entire populations: Coding the STOPP-START and Beers criteria for use with large, routinely collected population health datasets - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

26.10.2025 19:18 — 👍 3 🔁 1 💬 0 📌 0

So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care To undertake a formal process to identify and prioritise clinical topics for the updating of the Australian Pregnancy Care Guidelines and development of new Australian Postnatal Care Guidelines for th...

So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

26.10.2025 19:17 — 👍 2 🔁 1 💬 0 📌 0

Reporting guidelines can be used to foster reporting of evidence-based research principles: A cross-sectional study The purpose of our study was to examine the presence and the extent of items related to an evidence-based research (EBR) approach in reporting guidelines, as well as their features and how these items...

Reporting guidelines can be used to foster reporting of evidence-based research principles: A cross-sectional study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:40 — 👍 4 🔁 1 💬 0 📌 0

Network meta-analysis of prediction models using aggregate or individual participant data - A scoping review and recommendations for reporting and conduct Prediction models are essential in clinical decision-making for estimating the probability of current (diagnosis, screening) or future (prognosis) outcomes. Network meta-analysis (NMA) serves as a pow...

Network meta-analysis of prediction models using aggregate or individual participant data - A scoping review and recommendations for reporting and conduct - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:40 — 👍 3 🔁 1 💬 0 📌 0

Continuous predicted risks should be retained when deploying clinical prediction models Clinical prediction models are used to obtain predicted risks of a diagnosis or future event. While models can produce continuous predicted probabilities, these are often dichotomised or categorised i...

Continuous predicted risks should be retained when deploying clinical prediction models - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:39 — 👍 3 🔁 2 💬 0 📌 0

Development and Validation of Case-Ascertainment Algorithms for Hypertensive Disorders of Pregnancy Using Longitudinal Electronic Health Records Data Hypertensive disorders of pregnancy (HDP), including chronic hypertension, gestational hypertension, and preeclampsia/eclampsia, is a leading cause of maternal and perinatal morbidity. Accurate identi...

Development and Validation of Case-Ascertainment Algorithms for Hypertensive Disorders of Pregnancy Using Longitudinal Electronic Health Records Data - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:34 — 👍 2 🔁 1 💬 0 📌 0

In humble defence of unexplainable black box prediction models in healthcare The increasing complexity of prediction models for healthcare purposes – whether developed with or without artificial intelligence (AI) techniques – drives the urge to open complex ‘black box’ models ...

In humble defence of unexplainable black box prediction models in healthcare - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:33 — 👍 4 🔁 2 💬 0 📌 0

A scoping review identified additional considerations for defining estimands in cluster randomised trials An estimand is a clear description of the treatment effect a study aims to quantify. The ICH E9(R1) addendum lists five attributes that should be described when defining an estimand. However, the adde...

A scoping review identified additional considerations for defining estimands in cluster randomised trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:33 — 👍 4 🔁 5 💬 0 📌 0

Methodological and Reporting Rigor in Non-Inferiority and Equivalence Trials for Multimodality Cancer Treatment: Lessons from Breast Cancer Radiotherapy To investigate the methodological and reporting quality of non-inferiority (NI) or equivalence trials in breast cancer radiotherapy, providing suggestions for future NI/equivalence trials.

Methodological and Reporting Rigor in Non-Inferiority and Equivalence Trials for Multimodality Cancer Treatment: Lessons from Breast Cancer Radiotherapy - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:31 — 👍 3 🔁 1 💬 0 📌 0

Assessing the Impact of Unpublished Data on Network Meta-Analysis Outcomes in Outpatient Adults with Acute Migraine: A Study within a Review Methodological guidance recommends including both published and unpublished data in systematic reviews to enhance reliability and reduce potential bias.

Assessing the Impact of Unpublished Data on Network Meta-Analysis Outcomes in Outpatient Adults with Acute Migraine: A Study within a Review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:30 — 👍 3 🔁 1 💬 0 📌 0

Systematic reviews on the same topic are common but often fail to meet key methodological standards: a research-on-research study To assess 1)the frequency of overlapping systematic reviews (SRs) on the same topic including overlap in outcomes, 2)whether SRs meet key methodological characteristics and 3)to describe discrepancies...

Systematic reviews on the same topic are common but often fail to meet key methodological standards: a research-on-research study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:27 — 👍 11 🔁 6 💬 0 📌 0

Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions Jurisdictional scans are used to inform policy by systematically comparing how different jurisdictions define problems, design policies, and implement strategies. They provide insights into policy opt...

Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.10.2025 14:26 — 👍 4 🔁 3 💬 0 📌 0

Statistical model assessment in published dose-response meta-analyses is suboptimal: Evidence from a methodological review and re-analysis of 242 datasets Dose-response meta-analysis (DRMA) is a crucial clinical and epidemiological research tool for synthesizing exposure-risk relationships. Despite its growing use, facilitated by the availability of sta...

Statistical model assessment in published dose-response meta-analyses is suboptimal: Evidence from a methodological review and re-analysis of 242 datasets - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 13:33 — 👍 2 🔁 1 💬 0 📌 0

Effectiveness and Efficiency of an Add-on Active Outreach Strategy on Research Enrollments in a Drug Intervention Trial Adding an active outreach strategy for patients who do not respond to mail invitations may enhance clinical research recruitment; however, the effectiveness of this approach has yet to be formally tes...

Effectiveness and Efficiency of an Add-on Active Outreach Strategy on Research Enrollments in a Drug Intervention Trial - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 13:33 — 👍 3 🔁 1 💬 0 📌 0

Piloting QUADAS-3: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies QUADAS-2 is the most widely used tool for evaluating risk of bias and applicability concerns in diagnostic test accuracy studies within systematic reviews. QUADAS-2 has recently been updated to a new ...

Piloting QUADAS-3: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 13:32 — 👍 4 🔁 1 💬 0 📌 0

Write Your Abstracts Carefully - The Impact of Abstract Reporting Quality on Findability by Semi-Automated Title-Abstract Screening Tools Evidence synthesis, such as the conduct of a systematic review or clinical guideline development, is time-consuming, laborious, and costly. This is largely due to the vast amounts of titles and abstra...

Write Your Abstracts Carefully - The Impact of Abstract Reporting Quality on Findability by Semi-Automated Title-Abstract Screening Tools - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 12:56 — 👍 6 🔁 2 💬 0 📌 0

Impact of active placebo controls on estimated drug effects in randomised trials: a meta-epidemiological study To assess the impact of active placebo control versus standard placebo control interventions on estimated benefits of experimental interventions in pharmacological randomised clinical trials, and to e...

Impact of active placebo controls on estimated drug effects in randomised trials: a meta-epidemiological study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 12:53 — 👍 4 🔁 1 💬 0 📌 0

The AMSTAR 2 publication lacks explicit instructions on how to assess the appropriateness of statistical methods (item 11) and publication bias (item 15), and does not reflect advances in meta-analysi... As the quantity of published systematic reviews has increased substantially over the years, concerns about the methodological quality of this growing body of literature have been validly raised. AMSTA...

The AMSTAR 2 publication lacks explicit instructions on how to assess the appropriateness of statistical methods (item 11) and publication bias (item 15), and does not reflect advances in meta-analysis - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 12:51 — 👍 5 🔁 1 💬 0 📌 0

Machine Learning For Predicting Cardiovascular Events In Older Adults With Type 2 Diabetes Using Medicare Claims And Electronic Health Records To address the limitations of existing models for research and population health applications in older adults with type 2 diabetes, we developed and validated cardiovascular disease (CVD) and heart fa...

Machine Learning For Predicting Cardiovascular Events In Older Adults With Type 2 Diabetes Using Medicare Claims And Electronic Health Records - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 12:51 — 👍 2 🔁 1 💬 0 📌 0

User experience of Tool for Addressing Conflicts of Interest in Trials (TACIT) prototype: interview and questionnaire study To describe and analyse the user experience of a late-phase prototype of Tool for Addressing Conflicts of Interest in Trials (TACIT). The tool was developed primarily for guiding systematic reviewers ...

User experience of Tool for Addressing Conflicts of Interest in Trials (TACIT) prototype: interview and questionnaire study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 12:50 — 👍 4 🔁 2 💬 0 📌 0

Theory of Clinical Therapeutic Progress: Reconciling Equipoise With Fat-Tailed (Skewed) Outcomes Randomized controlled trials (RCTs) embody a paradox: they require equipoise—genuine uncertainty about treatment effects—to ethically protect participants, yet this very requirement can slow therapeut...

Theory of Clinical Therapeutic Progress: Reconciling Equipoise With Fat-Tailed (Skewed) Outcomes - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 11:58 — 👍 1 🔁 1 💬 0 📌 0

Sometimes different, often the same: guidance on how recruitment and retention in trials need to be tailored to enhance participation of ethnic minority groups: a qualitative interview study in Englan... Plain Language Summary: We spoke with 20 adults from a range of ethnic backgrounds across England. Participants emphasised that clear, honest communication and respect for different cultures and langu...

Sometimes different, often the same: guidance on how recruitment and retention in trials need to be tailored to enhance participation of ethnic minority groups: a qualitative interview study in England - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 10:46 — 👍 6 🔁 2 💬 0 📌 0

Reporting guidelines can be used to foster reporting of evidence-based research principles: A cross-sectional study The purpose of our study was to examine the presence and the extent of items related to an evidence-based research (EBR) approach in reporting guidelines, as well as their features and how these items...

Reporting guidelines can be used to foster reporting of evidence-based research principles: A cross-sectional study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 10:44 — 👍 5 🔁 3 💬 0 📌 0

Network meta-analysis of prediction models using aggregate or individual participant data - A scoping review and recommendations for reporting and conduct Prediction models are essential in clinical decision-making for estimating the probability of current (diagnosis, screening) or future (prognosis) outcomes. Network meta-analysis (NMA) serves as a pow...

Network meta-analysis of prediction models using aggregate or individual participant data - A scoping review and recommendations for reporting and conduct - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 10:43 — 👍 2 🔁 1 💬 0 📌 0

Continuous predicted risks should be retained when deploying clinical prediction models Clinical prediction models are used to obtain predicted risks of a diagnosis or future event. While models can produce continuous predicted probabilities, these are often dichotomised or categorised i...

Continuous predicted risks should be retained when deploying clinical prediction models - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 10:43 — 👍 4 🔁 1 💬 0 📌 1

Development and Validation of Case-Ascertainment Algorithms for Hypertensive Disorders of Pregnancy Using Longitudinal Electronic Health Records Data Hypertensive disorders of pregnancy (HDP), including chronic hypertension, gestational hypertension, and preeclampsia/eclampsia, is a leading cause of maternal and perinatal morbidity. Accurate identi...

Development and Validation of Case-Ascertainment Algorithms for Hypertensive Disorders of Pregnancy Using Longitudinal Electronic Health Records Data - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

10.10.2025 10:42 — 👍 1 🔁 1 💬 0 📌 0

Journal of Clinical Epidemiology

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