Journal of Clinical Epidemiology jclinepi

Key considerations for planning adaptive platform trials: part 2 There is increased interest in adaptive platform trials (APTs), i.e., complex randomised clinical trials (RCTs) focusing on a population or a setting, conducted according to a core protocol, with cont...

Key considerations for planning adaptive platform trials: part 2 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

06.03.2026 15:31 — 👍 0 🔁 0 💬 0 📌 0

Key considerations for planning adaptive platform trials: part 1 There is increased interest in adaptive platform trials (APTs), i.e., complex randomised clinical trials (RCTs) focusing on a population or a setting, conducted according to a core protocol, with cont...

Key considerations for planning adaptive platform trials: part 1 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

06.03.2026 15:30 — 👍 1 🔁 0 💬 0 📌 0

Living evidence and gap maps: a scoping review of automation and living mode parameters reported in 44 digital interfaces and their documentation To examine how continually updated, living evidence and gap maps (L-EGMs) with an online presence report planned update schedules, retirement plans, living status, use of automation across review stag...

Living evidence and gap maps: a scoping review of automation and living mode parameters reported in 44 digital interfaces and their documentation - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

06.03.2026 15:30 — 👍 1 🔁 0 💬 0 📌 0

Misusing I2 for Inconsistency, Overlooking OIS for Imprecision, and Ignoring the Continuum of Certainty Ratings: Common Pitfalls in GRADE Assessments The GRADE framework guides ratings of certainty in evidence that includes the possibility of rating down certainty in one or more of five domains. GRADE users face challenges in making certainty of ev...

Misusing I2 for Inconsistency, Overlooking OIS for Imprecision, and Ignoring the Continuum of Certainty Ratings: Common Pitfalls in GRADE Assessments - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

06.03.2026 15:30 — 👍 0 🔁 0 💬 0 📌 0

Cluster separation outperforms other metrics in validating multimorbidity patterns: Statistical simulation study Multimorbidity, defined as the presence of multiple long-term health conditions within an individual, remains a growing challenge in healthcare. Identifying frequently occurring multimorbidity cluster...

Cluster separation outperforms other metrics in validating multimorbidity patterns: Statistical simulation study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

06.03.2026 15:29 — 👍 2 🔁 0 💬 0 📌 0

Depression rating scales demonstrate significant correlations but systematic differences: a multicenter prospective cohort study using equipercentile linking To evaluate correlations and score equivalence among four widely used clinician-rated and self-report depression scales—the 17-item Hamilton Rating Scale for Depression (HAMD-17), 6-item Hamilton Rati...

Depression rating scales demonstrate significant correlations but systematic differences: a multicenter prospective cohort study using equipercentile linking - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

06.03.2026 15:28 — 👍 1 🔁 0 💬 0 📌 0

Editors' Choice: March 2026 The Journal of Clinical Epidemiology is committed to open science practices. Over the past year, we have implemented several changes to align the Journal more closely with this commitment. For example...

Editors' Choice: March 2026 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

06.03.2026 15:28 — 👍 0 🔁 0 💬 0 📌 0

Practical elements to consider when emulating a target trial When carefully designed and analyzed, target trial emulation, i.e., the analysis of observational data through the explicit emulation of the design components of randomized controlled trials (RCT), ca...

Practical elements to consider when emulating a target trial - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

04.03.2026 21:34 — 👍 3 🔁 1 💬 0 📌 0

Practical elements to consider when emulating a target trial When carefully designed and analyzed, target trial emulation, i.e., the analysis of observational data through the explicit emulation of the design components of randomized controlled trials (RCT), ca...

Practical elements to consider when emulating a target trial - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

28.02.2026 16:04 — 👍 5 🔁 2 💬 0 📌 0

Rethinking clinical trials in the multimorbidity era: The imperative for patient-centered tailored approaches Multimorbidity, the coexistence of two or more chronic conditions, affects about 40% of all adults and over half of adults over 60. The complexity of multimorbidity often renders traditional trial des...

Rethinking clinical trials in the multimorbidity era: The imperative for patient-centered tailored approaches - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

28.02.2026 16:04 — 👍 3 🔁 1 💬 0 📌 0

Crossing the null does not mean “no effect”: a survey of internal medicine physicians on the interpretation of effect estimates with wide confidence intervals Results with confidence intervals (CIs) crossing the null should not be interpreted as indicating no effect. We assessed how often clinicians make this error and explored predictors of correct interpr...

Crossing the null does not mean “no effect”: a survey of internal medicine physicians on the interpretation of effect estimates with wide confidence intervals - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

28.02.2026 16:03 — 👍 5 🔁 2 💬 0 📌 0

Estimating Causal Effects on Quality of Life Under Treatment Discontinuation: The ALTA-1L Trial Time to worsening in health-related quality of life (HRQoL) is increasingly used in oncology trials. Treatment discontinuation poses a challenge: once discontinued, patients cease HRQoL assessments, p...

Estimating Causal Effects on Quality of Life Under Treatment Discontinuation: The ALTA-1L Trial - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

28.02.2026 16:03 — 👍 2 🔁 1 💬 0 📌 0

Quantifying new threats to health and biomedical literature integrity from rapidly scaled publications and problematic research The last three years have seen an explosion in published manuscripts analysing open-access health datasets, in many cases presenting misleading or biologically implausible findings. There is a growing...

Quantifying new threats to health and biomedical literature integrity from rapidly scaled publications and problematic research - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

28.02.2026 16:02 — 👍 3 🔁 3 💬 0 📌 0

Existing Research Guidelines for Inclusive Trial Methodology. Working toward the integration of Qualitative Research, Equity, diversity, and inclusion (EDI) and Trial Methodology: a focused mapping re... Equity, diversity, and inclusion (EDI) are increasingly emphasised in clinical research, yet practical guidance for applying inclusion principles across all clinical trial stages remain limited. Quali...

Existing Research Guidelines for Inclusive Trial Methodology. Working toward the integration of Qualitative Research, Equity, diversity, and inclusion (EDI) and Trial Methodology: a focused mapping review. - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:10 — 👍 6 🔁 2 💬 0 📌 0

Psychometric properties and reference values for the instrumented timed-up and go test in adults The instrumented Timed Up and Go (iTUG) test is widely used in assessing mobility and predicting falls. However, the psychometric properties of a smartphone-based iTUG remain unclear, particularly wit...

Psychometric properties and reference values for the instrumented timed-up and go test in adults - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:10 — 👍 3 🔁 1 💬 0 📌 0

Estimating effective sample sizes using standard errors from appropriate analyses of cluster-randomised trials Cluster-randomised trials (CRTs) typically provide less information than similarly sized trials with individual randomisation due to correlation within clusters, i.e., the effective sample size (ESS) ...

Estimating effective sample sizes using standard errors from appropriate analyses of cluster-randomised trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:10 — 👍 3 🔁 2 💬 0 📌 0

No Normal Brain: How Demographic Exclusion Undermines Neuroimaging AI Validity Neuroimaging AI systems increasingly influence clinical decisions, yet demographic exclusions in training datasets may compromise their scientific validity and clinical safety. This analysis examines ...

No Normal Brain: How Demographic Exclusion Undermines Neuroimaging AI Validity - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:09 — 👍 3 🔁 2 💬 0 📌 0

Prioritizing topics for a Clinical Practice Guideline on SATB2-Associated Syndrome: Methodological rigor versus clinical usability SATB2-associated syndrome (SAS) is a rare genetic condition characterized by developmental delay and typical features. Currently, an evidence-based Clinical Practice Guideline (CPG) is being developed...

Prioritizing topics for a Clinical Practice Guideline on SATB2-Associated Syndrome: Methodological rigor versus clinical usability - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:09 — 👍 2 🔁 1 💬 0 📌 0

STrategies for developing REseArch Methods guidance (STREAM): protocol Health researchers rely on clear, trustworthy methods guidance (MG) to support the planning, conduct, analysis, and interpretation of their studies (e.g., guidance on study design, data collection, st...

STrategies for developing REseArch Methods guidance (STREAM): protocol - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:08 — 👍 2 🔁 1 💬 0 📌 0

Evaluation of GRADE Approach Adherence in Clinical Practice Guidelines: A systematic survey of criteria and their applications Many clinical practice guidelines (CPGs) claim to follow the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach, yet their actual adherence remains uncertain. We aimed...

Evaluation of GRADE Approach Adherence in Clinical Practice Guidelines: A systematic survey of criteria and their applications - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:08 — 👍 2 🔁 2 💬 0 📌 0

Evaluating empirical calibration of P-values under unmeasured confounding bias: a simulation study and real-world application To evaluate whether empirical calibration of P-values using negative controls can effectively control Type I and Type II errors under unmeasured confounding bias in both simulated and real-world obser...

Evaluating empirical calibration of P-values under unmeasured confounding bias: a simulation study and real-world application - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:08 — 👍 3 🔁 1 💬 0 📌 0

Influences on recruitment and retention to mental health randomised controlled trials from the perspective of trial staff: a qualitative evidence synthesis. Poor recruitment and retention are widely reported as problematic for many randomised controlled trials (RCTs). However, there is limited evidence on the context specific challenges faced by trial sta...

Influences on recruitment and retention to mental health randomised controlled trials from the perspective of trial staff: a qualitative evidence synthesis. - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 13:02 — 👍 2 🔁 1 💬 0 📌 0

Drug Approvals in Crowded Drug Classes Potentially Reflect Efficacy Over-Estimates and False Positivity: A Portfolio Analysis of Immune Checkpoint Inhibitor Trials Institutions making decisions regarding drug development, approval or insurance reimbursement require accurate estimates of drug efficacy that reflect the drug’s true value. Stein estimation and multi...

Drug Approvals in Crowded Drug Classes Potentially Reflect Efficacy Over-Estimates and False Positivity: A Portfolio Analysis of Immune Checkpoint Inhibitor Trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 12:57 — 👍 2 🔁 1 💬 0 📌 0

Use of clustering techniques for clinical and epidemiological research: practical tips using an example from rheumatology Clinical and epidemiological researchers may want to identify or determine groups with similar characteristics that exist within a dataset or population. For this purpose, clustering techniques can be...

Use of clustering techniques for clinical and epidemiological research: practical tips using an example from rheumatology - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 12:52 — 👍 3 🔁 1 💬 0 📌 0

Ratios are misleading exposure variables that compromise a regression model unless fundamental scaling assumptions are satisfied: a comment on Valente et al •The calculation of simple ratios is ubiquitous in biomedical health research.•Ratios are formulated by dividing a numerator (Y) for a denominator (X) variable.•Ratios are spurious if underlying assum...

Ratios are misleading exposure variables that compromise a regression model unless fundamental scaling assumptions are satisfied: a comment on Valente et al - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 12:48 — 👍 7 🔁 4 💬 0 📌 0

The influence of exposure and observed mortality definitions when estimating lung cancer attributable mortality to secondhand smoke exposure The estimation of attributable mortality to secondhand smoke (SHS) exposure depends on the conceptual framework used. This framework encompasses the population group considered for observed mortality ...

The influence of exposure and observed mortality definitions when estimating lung cancer attributable mortality to secondhand smoke exposure - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 12:47 — 👍 2 🔁 1 💬 0 📌 0

The epistemological trap from the real-world evidence concept. ‘Real-world’ evidence (RWE) and related terms are gaining popularity in scientific literature, usually in reference to evidence collected outside of traditional randomized controlled trials (RCT). How...

The epistemological trap from the real-world evidence concept. - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

22.02.2026 12:47 — 👍 7 🔁 3 💬 0 📌 1

Evaluation of tools used to assess adherence to PRISMA 2020 reveals inconsistent methods and poor tool implementability: part I of a systematic review Numerous studies have assessed the adherence of published systematic reviews to the PRISMA 2020 statement. We aimed to summarize the characteristics and methods of development of the tools used to ass...

#CochraneDaily Just published! Study of assessments of adherence to PRISMA 2020 reveals inconsistent methods and poor tool implementability, highlighting the need for a standardised #PRISMA 2020 assessment tool, which the authors are working on
www.jclinepi.com/article/S089...
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03.02.2026 08:51 — 👍 3 🔁 2 💬 0 📌 0

Looking to assess adherence to TRIPOD+AI?

We have a new #openaccess paper in @jclinepi.bsky.social

"Adherence to TRIPOD+AI guideline: an updated reporting assessment tool"

--> linkinghub.elsevier.com/retrieve/pii...

#machinelearning #AI #metascience #transparency

27.01.2026 21:34 — 👍 4 🔁 2 💬 0 📌 0

A protocol for the development of a Core Outcome Set (COS) for adults with depression Heterogeneous outcome measurement limits the comparison and combination of results from randomized controlled trials (RCTs) and observational studies aimed at evaluating therapeutic interventions for ...

A protocol for the development of a Core Outcome Set (COS) for adults with depression - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

19.01.2026 19:52 — 👍 2 🔁 1 💬 0 📌 0

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