Bosse lab at CSSB Hamburg

YouTube video by Chan Zuckerberg Biohub Network Comparative Systems Virology Symposium: Jens Bosse

f you’re interested in our latest developments have a look at: Comparative Systems Virology Symposium: Jens Bosse youtu.be/PlAcAR1-IJA?si… via @YouTube

Thanks to the @czbiohub for organizing and my amazing team for the great data!

Frontiers in Comparative Systems Virology Symposium 2025 Be part of this exciting gathering to shape the future of comparative systems virology!

A big thanks to Carolina Arias, Amy Kistler and Noam Stern-Ginossar for organizing an amazing meeting on comparative systems virology yesterday @czbiohub.bsky.social in San Francisco!

www.czbiohub.org/events/front...

📣 Good News!

You can still register to join @landaulabcssb.bsky.social for their Functional Amyloid Meeting!

landau-cssb.de/registration/

@meytallandau.bsky.social @emilgustavsson.bsky.social
@amyloid-sam.bsky.social @jankosinski.bsky.social
@bosse-lab.bsky.social @carobarisch.bsky.social

Are you interested in supporting a young international team of scientists as a part-time job? We have an open 25% team assistant position in our lab in Hamburg at the Centre for Structural Systems Biology (CSSB)! Please apply via: mhh.hr4you.org/job/view/327...

Congratulations to Thomas Mettenleiter for winning this year's Loeffler Frosch Medal awarded for his special service to virology as the long-term President of the Friedrich-Löffler Institut

The third session of our symposium is Bacteria. The session begins on May 8 with a talk by Hinrich Schulenburg from @uni-kiel.de

Register today: cssb-hamburg.de/symposium2025

@carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @landaulabcssb.bsky.social @jankosinski.bsky.social

Check out this video summary of the first day of our upcoming symposium "Mechanisms of Infection - from structure to translation."

Register by April 8: t1p.de/gztmj

@bosse-lab.bsky.social, @carobarisch.bsky.social, @jankosinski.bsky.social, @meytallandau.bsky.social @topf-lab.bsky.social

Alan Cowman from WEHI @wehi-research.bsky.social will give the second talk in our Parasites session on May 7.

Register to attend by April 8: t1p.de/gztmj

@carobarisch.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social @robinsonmeyer.bsky.social

The fourth and final speaker in the Parasites session of our symposium is Ron Dzikowski from The Hebrew University of Jerusalem.

Register for the symposium by April 8: t1p.de/gztmj

@leibnizliv.bsky.social @fzborstel.bsky.social @uni-hamburg.de @embl.org @helmholtzhzi.bsky.social

CSSB alumnus Michael Filarsky from @unituebingen.bsky.social will give a talk during our "Parasites" session on May 7.

Take a look at the symposium programme here:
t1p.de/h48ek

@leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @uni-hamburg.de

The second session of our symposium is "Parasites".

Emily Derbyshire's talk entitled "Interdisciplinary approaches to reveal parasite vulnerabilities" will start the session.

Register by April 8: t1p.de/gztmj

@meytallandau.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social

On May 7, Ilaria Ferlenghi from GSK will give a talk entitled "Fast-Track to Immunity: The Fusion of Structural Biology, AI, and ML in Vaccine Innovation"

Register today: t1p.de/gztmj

@carobarisch.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social @meytallandau.bsky.social

Congratulations also from me. It was an honor to give a talk at your ceremony! Thanks to Dan for inviting me.

🚨 Save the date! 🚨
We're thrilled to announce our International Symposium on Cell & Structural Biology of Host-Pathogen Interaction
📅 Sept 10-12, 2025
📍
@cssbhamburg.bsky.social Hamburg

Registration starts soon
For more info:
humansandmicrobes2025.de

Our symposium "Mechanisms of Infection: from structure to translation" will take place from May 7-8.

Over the next weeks, we will be introducing our 15 confirmed speakers.

Sriram Subramaniam from the University of British Columbia will be giving the key note.

www.cssb-hamburg.de/symposium2025

The first session of our symposium "Mechanisms of Infection: from structure to translation" is Viruses.

Ben tenOever from New York University will give the first talk in this session.

t1p.de/xu79k

@carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @jankosinski.bsky.social

About 1,5 years ago I predicted in a little writeup for the ExC RESIST that ever more capable LLMs will soon make scientific review articles obsolete. From the initial results I have from #OpenAIs #DeepResearch, this is happening very soon…

Hi Joe, sure we have a script. I can send it to you

We are very excited that our in-situ structural analysis of the Ebola virus nucleocapsid assembly cascade is now published in @cellpress.bsky.social!

Join us in Hamburg, 7th-8th of May, at the CSSB! cssb-hamburg.de/symposium2025

Conclusion slide on RNA assessment

Conclusion of RNA assessors in #CASP16 - we are still in the “template” phase. Prediction of nucleic acids structure is still challenging for targets without templates, often relying on intuition. No big leap in accuracy since CASP15. AI based methods have not (yet?) made a major difference.

This is a super interesting question. It doesn’t get the dimer right, either

Stone conclusion by hearsay from day 1 at #CASP16 all top methods used AF3 somehow. Improvements are made by increased sampling (FFT etc), ranking of models still a challenge. Some improvement on antibodies.

Conclusions from RNA section at #CASP16, without a template all fail. All small targets had a template.

Conclusion for ligand session in #casp16, without a template methods fail

Histogram of performance of antibody antigen structure prediction

#CASP16: are we making progress in predicting protein-protein complexes?Not much in general, but ….

One method (Kozakov Vajda) shows great improvement in predicting structure of antibody-antigen complexes. 🧪 🧬

Conclusion slide of oligomer prediction assessment

#CASP16 assessors’ summary of the protein complex category 🧪 🧬

Conclusions of assessment of 3D category

Assessors’ conclusions of the 3D category (individual protein chains) of #CASP16 🧪

Our Herpesfolds paper is out in Nature Communications! rdcu.be/d1uM7 Congrats to Timothy Soh,
@sofiaaognibene
, Saskia Sanders, Robin Schaeper and Benedikt Kaufer!
Have a look at our database at herpesfolds.org by Malte Kansy

Strain is www.ncbi.nlm.nih.gov/nuccore/ON95...