Amali Samarasinghe

Review of CKD Drug Safety With Breastfeeding | Docwire News A review revealed which drugs commonly used in chronic kidney disease (CKD) have been found safe to use while breastfeeding. However, evidence for many therapies is still lacking.

A review revealed which #CKD drugs are safe to use while #breastfeeding but evidence for many therapies is still lacking. #kidneydisease #nephrology #nephsky docwirenews.com/post/review-...

Going to add this to my lecture slides.

GLP-1RA Semaglutide Delays the Progression of ADPKD Through Regulation of Glycolysis, Mitochondria Function and Ketosis - PubMed Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease that is caused by mutations in PKD genes. Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are a class of medicati...

GLP1ra in ADPKD?

pubmed.ncbi.nlm.nih.gov/40815122/

T1b

BP Measurement: In 2017 ‘proper’ technique was recommended and that has transitioned to standardized technique in 2025. Let’s all use a checklist…and let’s use it every time! How close is your regular practice to this standard?
#NephJC

Use of genetics for kidney disease research reveals an array of variants in COL4A genes and a resulting range of disease presentations. From hematuria to Alport syndrome, genetic data has provided a new basic research basis for genotype-phenotype correlations. kidney.pub/KN1707-08 #ASNKidneyNews

Cartoon

Poignant cartoon on therapeutics (here vaccines) in pregnancy

absolutelymaybe.plos.org/2025/06/27/d...

Renalism is a similar issue!

From @hildabast.bsky.social

Cystatin C vs. Creatinine in AKI recovery
eGFRcr may overestimate kidney function post-AKI due to muscle loss. A KI Reports study found eGFRcys was lower, flagged more CKD, and a higher creatinine–cystatin C index (CMI) predicted lower 5-year mortality. www.kireports.org/article/S246...

Sodium-Glucose Cotransporter-2 Inhibitor Therapy and... : Clinical Journal of the American Society of Nephrology study within the Veterans Health Administration included adults with an ADPKD diagnosis code who initiated SGLT2i between January 2017 and May 2023. Repeated measures models were used to evaluate eGFR...

Promising!

flozination in ADPKD (mostly older adults with DM or CVD) - presumably those with another valid indication - associated with slower GFR slope

journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social #CJASN

With no obvious harm signal

We’re making measles great again

😡😡😡

Metformin in Advanced CKD — NephJC Should we continue metformin in eGFR under 30 ml/min? The visual abstract by Cristina Popa summarizes the conclusions from the Scottish cohort using target trial methodology.

Hey #NephSky and #MedSky
Check out the VA for our discussion 4/15/25 at 9pm EST
Metformin-Should I Stay or Should I Go (in patients with advanced CKD)
VA by @nephroseeker.medsky.social
www.nephjc.com/news/metformin-ckd-va

Dialysis-Imposed Patterns of Nocturnal Sleep Duration: A... : Kidney360 nal study, patients on in-center hemodialysis were equipped with activity trackers (Fitbit® Charge 2™). Nocturnal sleep duration was assessed according to dialysis start time (early starters: before 8...

Interesting study of sleep duration by using Fitbit trackers in hemodialysis

From the Renal Research Institute in @asnpublications.bsky.social K360

journals.lww.com/kidney360/pa...

1/

#NephSky

Spring has sprung - Vancouver

Venous Thromboembolism Prevention in Nephrotic Syndrome: The Role of Aspirin, Vitamin K Antagonists, and Direct Oral Anticoagulants ca. 2025 from @kireports.bsky.social @saynanorouzi.bsky.social @kdjhaveri.bsky.social
#Nephpearls #NephSky

👉 www.kireports.org/article/S246...

Daily monitoring of sCys in patients at risk of AKI would facilitate timely detection and potentially improve clinical outcomes. Future research should focus on validating sCys diagnostic criteria and integrating it with other biomarkers to enhance AKI management. bit.ly/CJASN0654
#ASNCJASN

Don'T Worry, I'Ll Wait - Worry GIF ALT: Don'T Worry, I'Ll Wait - Worry GIF

Even if CONVINCE had lower enrollment than planned and a healthier cohort than average ESKD patient, name another 1000+ person RCT that shows a mortality benefit for people on HD.

#nephmadness

B-blockers are now first line antihypertensives in haemodialysis population while ACEI hold the ground in peritoneal dialysis individuals #UKKidney
www.ukkidney.org/sites/defaul...

🚨NEW MAJOR GUIDELINE!🚨

We have released a key guideline on managing blood pressure in patients on dialysis

One of the first of its kind, this unique & comprehensive guideline makes important recommendations for BP targets, treatment & care strategies.

➡️Download now: ow.ly/pABq50ViWCB

CKM Syndrome: Finally recognizing the connection between the heart, kidney & metabolic syndrome The concept of Cardiovascular-Kidney-Metabolic (CKM) syndrome highlights the intricate interplay between cardiovascular, kidney, and metabol

Want to read more about CKM syndrome, that ASN/AHA are trying to move the needle on mortality with integrated patient care.
Excellent readable summary from
KI reports community.
#NephSky
www.kireportscommunity.org/post/ckm-syn...

YouTube video by KDIGO KDIGO ADPKD Guideline Key Takeaways - Nomenclature, Diagnosis, Prognosis, and Prevalence

Convenient @kdigo.org series of quick summary videos here too: www.youtube.com/watch?v=KSpZ...
Interesting that #flozins are_not_recommended for ADPKD, & I like the emphasis on ABPM &/or home BP monitoring, 👀🤓😀

Cardiovascular Safety, Efficacy of Denosumab Versus Oral Bisphosphonates in Patients on Dialysis | Docwire News A study compared the risk for cardiovascular events and fracture prevention benefits of denosumab versus oral bisphosphonates among dialysis-dependent patients.

🦴 A study compared #cardiovascular risks and #fracture prevention benefits of denosumab versus oral bisphosphonates in patients on #dialysis. #nephrology #nephsky

🙈 not what we want to see

Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review ca. 2025
#Nephpearls #NephSky

👉🏼 pubmed.ncbi.nlm.nih.gov/40063723/

#NephSky #MedSky
We support our Nephrology colleagues everywhere!
This is not acceptable, free Dr. Alawieh.

The Different Colors Of Peritoneal Dialysate During a night call in my first year of nephrology fellowship, I was asked a question that I had never heard before: ‘What do I do when I see black effluent d

What does a green PD fluid effluent bag mean?

This and more in this RFN blog piece

www.renalfellow.org/2025/03/12/d...

By @drcoolbeans.bsky.social

#NephSky