Raymundo D Hernandez, PhD

Sign up to join our VERY FIRST Welcome Action Hour here:
zoom.us/webinar/regi...

Meet some of the team, get a little pep-talk from Nobel Laureate Dr. Victor Ambros, take action in community, AND get an infusion of hope.

Sounds like the perfect evening activity to me! See you there.

This one is for all my behavioral and social scientists out there! Science is science, so join in. #AcademicSky

Thanks to @cossa.bsky.social for inviting me to post a blog! First time since I was a teenager and used one to live stream my emo era thoughts. 😂
@sciforgood.bsky.social

Per a question to the chair from Senator Durbin: $400 M increase in the bill.

My AI chatbot thinks my idea is fundable A dialogue with artificial intelligence has changed how Angela Steinauer thinks through her ideas. The trick is staying sceptical and asking better questions.

A dialogue with artificial intelligence has changed how Angela Steinauer thinks through her ideas

go.nature.com/453z6xC

AI expands the repertoire of CRISPR-associated proteins for genome editing A generative artificial-intelligence tool has designed a synthetic CRISPR system that successfully edits human DNA and sharply reduces off-target effects.

A generative artificial-intelligence tool has designed a synthetic CRISPR system that successfully edits human DNA

go.nature.com/4mFJBPd

More on the Kathuria Lab's groundbreaking work: "one of the first times scientists have been able to generate an organoid with tissues from each region of the brain connected and acting in concert."

hub.jhu.edu/2025/07/25/h...

🧪 @jhu.edu

📣 Action item for the day! 🧪

SMART tool builds proteins on cell surfaces Researchers can target effector proteins to cells on the basis of which molecules those cells express.

Scientists have created a tool that manufactures working proteins directly on the surfaces of cells

go.nature.com/3IMPyv0

Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system The locus coeruleus (LC), the brain’s main source of noradrenaline, has received increased attention due to the recently unveiled heterogeneity of its…

Honored to have been invited to contribute to this comprehensive review on neuropeptide signaling and its impacts on the locus coeruleus noradrenergic system 🔵🧠🧪.

www.sciencedirect.com/science/arti...

Using a roll of toilet paper to explain histone modifications and #chromatin accessibility -- @katzlab.bsky.social in action #Epigenetics -- 🙏 we had almost 70 people, bumping up against fire code #StandUpForScience @standupforscience.bsky.social @sci4ga.bsky.social

Top: CD133 showed specific enrichment on the apical surface of radial glial cells (RGCs) in the developing ventricular zone (VZ) from postnatal day 0 (P0) to P15. Ciliary membrane marker (ARL13B) and the ciliary microtubule marker acetylated-tubulin (ac-TUB) indicated ependymal cell (EPC)-lineage differentiation. Cell proliferating marker (Ki67) and neural stem cell (NSC)-lineage marker (ASCL1) indicated NSC-lineage transition. The framed region was further magnified to show details. The boundary between lateral ventricle (LV) and VZ was denoted by the yellow dotted line for better distinguishing ciliary ac-TUB and cytoplasmic ac-TUB in (B). The scale bars are 20 μm. Bottom: A model illustrating how TFEB functions in the process of bGPC specification during VZ development.

#NeuralStemCells (NSCs) & ependymal cells (ECs) are derived from #RadialGlialCells. This study uses #scRNAseq to characterize cell fate trajectories in the developing #VentricularZone, identifying TFEB as a regulator of the NSC/EPC balance @plosbiology.org 🧪 plos.io/3HbrsJG

From Senator @murray.senate.gov: the Senate's proposed NIH budget would reject 40% cuts, increase funding by $400M.

"We're not going to give up the fight against cancer, Alzheimer's or rare diseases."

Message to scientists: "we support you. We need you to stay here & keep this research going."

The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.

"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.

Reminder! Register for this webinar hosted by @sfn.org on August 5.

Top: Optogenetic activation of anterior but not posterior D2R-neurons impaired WM under low cognitive load. Top left: Schematic illustrating virus injection and optic fiber implantation in DMS of Adora2a-Cre (+) mice. Top middle: Representative images showing ChR2 (red) and DAPI (blue) expression in DMS. Top right: Photo-stimulation of ChR2 led to notable c-Fos induction in DMS (green). Scale bar, 100 μm. Bottom: Optogenetic inhibition of D1R-neurons selectively improved WM maintenance and retrieval under higher cognitive loads. Bottom left: Schematic illustrating virus injection and optic fiber implantation in DMS of Drd1-Cre (+) mice, plus a representative images showing ArchT expression (green), DAPI staining (blue) in DMS, and its projections to the GPi and SNR. Bottom right: Photoinhibition of ArchT resulted in c-Fos induction in DMS (red). Scale bar, 100 μm

Untangling the role of the two types of striatal #dopamine neurons in #WorkingMemory has been challenging. This study shows that D2R neurons primarily govern WM under low cognitive load, while D1R neurons take over when cognitive load increases @plosbiology.org 🧪 plos.io/4mfgx0s

📢 PUBLISHED @natgenet.nature.com

📰The LISTEN principles for genetic sequence data governance and database engineering.

A Perspective by Colin J. Carlson, @ctrlalttim.com and colleagues.

⬇️

www.nature.com/articles/s41...

📣 LEADERSHIP UPDATE: Jennifer Swails, MD, FACP, has been named the Department of Medicine's new Vice Chair of Education! We can't wait to see how her leadership will impact our learners.

Congratulations, Dr. Swails! #DOMKudos

Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

Excited to see our most recent project published in @npp-journal.bsky.social !
We show that the timing of THC exposure during development—prenatal vs. postnatal—leads to opposite effects on social behavior and microglial function in the amygdala. Timing matters!

www.nature.com/articles/s41...

Odds of winning NIH grants plummet as new funding policy and spending delays bite Funding multiyear grants up front will sharply cut number of investigators receiving awards

Researchers’ chances of winning a grant from the National Institutes of Health have dropped under a new policy. scim.ag/4f7uew2

Alert: The Trump administration is quietly slashing new NIH grant awards, and it's not via the budget NIH’s sudden move to multiyear grant funding is forcing shocking cuts in the number of grants funded. This is an effective budget cut. It's bad, folks.

New, from an anonymous NIH insider: Trump is being pushed to spend more NIH money. The White House is ordering NIH to do multi-year budgets for awards. This budget trick means fewer awards, fewer labs funded, and lower paylines for researchers. 🧵
donmoynihan.substack.com/p/alert-the-...

The Transmitter @thetransmitter.bsky.social is looking for a Director of Engagement and Marketing to engage neuroscientists with our award-winning content. For more information, please visit: simonsfoundation.wd1.myworkdayjobs.com/en-US/simons...

#neuroskyence

Check out these liver #organoids from Dr. Takanori Takebe's lab!

Dr. Norikazu Saiki and the team produced organoids capable of forming their own internal blood vessels and coagulation factors.

Article: go.nature.com/44QbXPs
Discussion: bit.ly/3IGfUP1

PNAS and PNAS Nexus Logos Early-Career Researcher Workshop Friday, September 12 Button: I'm Interested

PNAS is hosting a virtual Early-Career Researcher (ECR) Workshop on September 12 from 1–2:30 PM (EDT) to discuss how ECRs can engage with PNAS Special Features, what defines a strong article, and more. Seats are limited, and we’re gauging interest via this survey: www.surveymonkey.com/r/XZ9N6PG

New preprint for the SCIMaP project: we show how accounting for commuter flows reveals the broad extent of economic losses that will result from NIH funding cuts

A remake of the GOP logo with the text: Pedophile Protectors. There is a red and blue elephant in the middle of the logo.

fantastic work from @melcooperphd.bsky.social - what are these beautiful networks doing in our brains?

Are you a senior graduate student, postdoctoral researcher, or early-stage independent investigator looking to get involved in scientific publishing? Apply to join JNeurosci’s ECR Advisory Board by July 25, 2025, 5pm ET.
Learn more: https://www.jneurosci.org/content/ecr-board-applications

Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy - Nature Neuroscience McGeachan et al. observe oligomeric tau in synapses from individuals with progressive supranuclear palsy and provide evidence that tau pathology may spread through the brain via synapses.

Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy, including postmortem PSP brain samples and a living human brain slice culture model

www.nature.com/articles/s41...

👨🍼 Are you balancing early parenthood & #neuroscience research?
IBRO Parenthood #Grants support early-career researchers during their parental leave to ensure research continuity.

Find out more: buff.ly/UdrcBIR

#IBROinAsiaPacific #IBROinUSCanada #IBROinAfrica #IBROinLatAm #IBROinEurope