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CRC1218

@crc1218.bsky.social

The #CRC1218 tackles the challenge of understanding how #mitochondria communicate with the rest of the #cell to regulate fundamental processes. Funded by #dfg https://sfb1218.uni-koeln.de/

125 Followers  |  145 Following  |  32 Posts  |  Joined: 17.01.2025
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Posts by CRC1218 (@crc1218.bsky.social)

We’re happy to announce that we’ve awarded a new Family Grant to support our postdoctoral researcher Marijana Croon (@marijanacroon.bsky.social).
The grant helps researchers balance excellent science with family responsibilities.
Congratulations, Marijana—we’re excited to support your work!

09.03.2026 09:51 — 👍 2    🔁 1    💬 1    📌 0
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We’re excited to share that also this year, we’ve offset CO2 emissions for all travel grants awarded to our early career researchers in 2025! 🌱 The CRC1218 is committed to fostering scientific progress while protecting the planet🌍
#SustainableScience #ScienceForTheFuture

15.12.2025 08:38 — 👍 2    🔁 0    💬 0    📌 0

The Female Mentoring Program is a common effort together with the CRCs 1403 and 1451!
@sfb1403.bsky.social

11.12.2025 09:50 — 👍 0    🔁 0    💬 0    📌 0
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🌟 Exciting Kick-off for our Female Mentoring Program! 🌟
Last Friday our mentees kicked off their journey with a hands-on workshop, learning the core principles of effective mentoring and how to build an independent, impactful mentoring relationship. 💪✨
#WomenSupportingWomen #FemaleMentoring

11.12.2025 09:50 — 👍 3    🔁 1    💬 1    📌 0

The Female Mentoring Program is a common effort together with the CRCs 1403 and 1451!
@sfb1403.bsky.social

11.12.2025 09:49 — 👍 0    🔁 0    💬 0    📌 0

Leucine reduces E3 ubiquitine ligase cofactor SEL1L at mitochondria, elevating OMM protein abundance to enhance metabolic respiration. The labs of Thorsten Hoppe and Jan Riemer (@riemerlab.bsky.social) furthermore assign a role to this cascade in metabolic disorders and cancer across species.

14.11.2025 07:59 — 👍 3    🔁 0    💬 0    📌 0
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Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature Cell Biology Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...

A publication rarity these days: An author list significantly shorter than the paper title!
www.nature.com/articles/s41...
Congratulations to our Advanced PostDoc Grant Awardee, Qiaochu Li (@qiaochuli.bsky.social), for her discoveries published in NCB [see thread]:

14.11.2025 07:58 — 👍 4    🔁 0    💬 1    📌 1
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The mitochondrial disulphide relay substrate FAM136A safeguards IMS proteostasis and cellular fitness The mitochondrial disulphide relay is the key machinery for import and oxidative protein folding in the mitochondrial intermembrane space. Among IMS p…

Congratulation also to the @riemerlab.bsky.social who just identified FAM136A as a new substrate of the mitochondrial disulphide relay and its implementations in IMS proteostasis and cellular fitness.
Check it out: www.sciencedirect.com/science/arti...

04.11.2025 14:29 — 👍 5    🔁 2    💬 0    📌 1
JCI - Sulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release

👉Paper alert👈
Check out the latest read from the Schwarz lab: Fu and Kohl identify persulfidation loss and hydrogen sulfide release as consequence of full-body SOX-deficiency in mice. Congratulations to everybody involved!👏
www.jci.org/articles/vie...

04.11.2025 14:14 — 👍 1    🔁 0    💬 0    📌 0
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Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity Ubiquitin is a conserved modifier regulating the stability and function of numerous target proteins. In all eukaryotes, polyubiquitin precursors are g…

📣Publication alert📣
A wonderful collaborative effort of the CRC 1218:
The lab of Mafalda Escobar-Henriques reveals that C-terminally extended ubiquitin (CxUb) is essential for mitophagy, proteostasis and longevity through a previously undefined CxUb-Ufd2 axis.
www.sciencedirect.com/science/arti...

04.11.2025 14:12 — 👍 1    🔁 0    💬 0    📌 0
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A big thank you to Thomas Splettstößer for leading an insightful Adobe Illustrator workshop on visual communication in science for our PhDs & PostDocs! We’re excited to apply what we’ve learned! 🙌
#AdobeIllustrator #VisualCommunication #Science #WorkshopSuccess

03.09.2025 09:33 — 👍 1    🔁 0    💬 0    📌 1

Publication alert! Congratulations to everybody involved in this collaborative effort👏

11.08.2025 09:08 — 👍 3    🔁 0    💬 0    📌 0

@crc1678.bsky.social, @annamariaregina.bsky.social, @franziskaottens.bsky.social, @riemerlab.bsky.social, it was a pleasure organizing this with you!

04.08.2025 12:49 — 👍 3    🔁 0    💬 0    📌 0
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🌟 What an incredible event! Amazing location & fantastic science. 🌟
Our Graduation Symposium PhDone last Friday was a great success!
Huge thanks to our speakers for their insightful and emotional presentations, and to everyone for the valuable networking.
#ECR #mitoCRC #PhDone

04.08.2025 12:44 — 👍 7    🔁 3    💬 1    📌 1

A common effort together with the CRCs 1403 and 1451!
@sfb1403.bsky.social

24.07.2025 07:18 — 👍 1    🔁 0    💬 0    📌 0
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What an exciting step in the careers of Camilla Franchino, Deniz Savcigil and Sandrina Campos Macas, who just joined our Mentoring Program! Promoting career advancement and professional development through impactful networking. We wish you a successful journey!👩‍🔬🚀
#CareerDevelopment #WomenEmpowerment

24.07.2025 07:17 — 👍 1    🔁 0    💬 1    📌 0

@cecad.bsky.social, @crc1678.bsky.social, @sfb1403.bsky.social, Expect our challenge to beat us next year!

03.07.2025 14:21 — 👍 3    🔁 0    💬 0    📌 0
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🚴 This. was. great! 🚴‍♀️
In this year‘s #CityCycling, the #mitoCRC made it into the #Top10 of the Uniclinis, which was the best team in all of Cologne! Well done! We are really impressed by all the #sustainability enthusiasts around us!
Photo: Our youngest team member😍
#Stadtradeln #Köln #Klimaschutz

03.07.2025 13:45 — 👍 3    🔁 0    💬 1    📌 1

What an outstanding achievement by our #mitoRTG member Annamaria Regina, (@annamariaregina.bsky.social‬)! We are extremely proud of your #passion and engagement in #ScienceCommunication!
#FameLab

30.06.2025 07:31 — 👍 5    🔁 1    💬 0    📌 0

📣Lecture Announcement📣
Join us: Next Monday, the CRC 1218 and the CRC 1403, will host an interactive lecture on #ResearchDataManagement - "Folders and File Names 101: Because organising data can be hard".
Don't miss it:
🗓️ 23.06. at 10 AM
📍CECAD Lecture Hall

@sfb1403.bsky.social #datascience

17.06.2025 12:57 — 👍 2    🔁 1    💬 0    📌 0
Prof. Dr. Aleksandra Trifunovic // Max Delbrück-Preis 2025
YouTube video by UniversitaetzuKoeln Prof. Dr. Aleksandra Trifunovic // Max Delbrück-Preis 2025

🏆We are extremely proud of our Vice Spokesperson Prof. Aleksandra Trifunovic who just received the Max Delbrück Award 2025 of @unicologne.bsky.social‬. A well-deserved recognition of her outstanding scientific achievements. Congrats!🎉
▶️ youtu.be/ayE9q9nKvyc
#mitochondria #lifescience #UniKöln

19.05.2025 09:47 — 👍 11    🔁 1    💬 0    📌 0

Congratulations to our mitoCRC project leader Prof. Jens Brüning on receiving the University Award 2024 in the category of Research of @unicologne.bsky.social in recognition of his exceptional scientific achievements!

19.05.2025 09:14 — 👍 14    🔁 1    💬 0    📌 0

Apologies for the missing last name: Dr. Andromachi Pouikli
And recently joined Bluesky: @qiaochuli.bsky.social

15.05.2025 14:03 — 👍 1    🔁 0    💬 0    📌 0
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Big congratulations to the three awardees of our mitoCRC Advanced PostDoc Grant! We're thrilled to support Dr. Qiaochu Li, Dr. @aleksandra-zecic.bsky.social and Dr. Andromachi in their first steps toward an independent research line. Well-deserved success! 🎉
#mitochondria #PostDoc #womeninscience

15.05.2025 09:47 — 👍 6    🔁 0    💬 2    📌 2
Cell-to-mitochondria communication by regulating the translation of NEM mRNAs. The translation of NEM mRNAs serves as a crucial communication node, integrating incoming signals and output cellular responses. Translation is regulated by binding to RBPs, which respond to incoming cellular signals (e.g. mTORC1, AMPK and insulin) and control translation in both time and space. In turn, ribosomal stress caused by stalled ribosomes transmits information about mitochondrial status and initiates stress responses. Created in BioRender by Rugarli, E., 2025. https://BioRender.com/d27y662. This figure was sublicensed under CC-BY 4.0 terms.

Cell-to-mitochondria communication by regulating the translation of NEM mRNAs. The translation of NEM mRNAs serves as a crucial communication node, integrating incoming signals and output cellular responses. Translation is regulated by binding to RBPs, which respond to incoming cellular signals (e.g. mTORC1, AMPK and insulin) and control translation in both time and space. In turn, ribosomal stress caused by stalled ribosomes transmits information about mitochondrial status and initiates stress responses. Created in BioRender by Rugarli, E., 2025. https://BioRender.com/d27y662. This figure was sublicensed under CC-BY 4.0 terms.

In their Review, Eleonora Zilio, Elena Rugarli and colleagues @cecad.bsky.social @crc1218.bsky.social discuss the role of mitochondrial mRNA translation in cellular communication.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria

13.05.2025 14:03 — 👍 7    🔁 2    💬 0    📌 0
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STADTRADELN - Radeln für ein gutes Klima Beim Wettbewerb STADTRADELN trittst du 21 Tage in die Pedale für mehr Radförderung, Klimaschutz und Lebensqualität in deiner Kommune.

🚴‍♂️ mitoCRC joins #Stadtradeln 2025!
From June 11–July 1, we’re cycling for climate & health – and challenging @crc1678.bsky.social & CRC 1403!
Join our team “CRC 1218 – mitoCRC” (under Gesunde Uniklinik) and help us pedal to victory! 🌍💪

🔗 Register: www.stadtradeln.de/koeln

#BikeForClimate #mitoCRC

24.04.2025 13:26 — 👍 2    🔁 0    💬 0    📌 0
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In recognition of his key role in the #mitoCRC and his valuable skill set, we’ve awarded our talented PostDoc Robert Düster a Family Support Grant! We hope to support the reconciliation of work and family life to better promote young talents in science.
#mitoResearch #Equality #FamiliesInScience

15.04.2025 11:46 — 👍 4    🔁 0    💬 0    📌 0
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📢Registration open!📢
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!

🗓 29.09.-02.10.2025
📍Engelberg, CH

👉 meetings.embo.org/event/25-mit...

15.04.2025 08:28 — 👍 5    🔁 0    💬 0    📌 1
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👩‍🔬mito-RTG at KölnerKinderUni👨‍🔬

The mitoRTG hosted 2 workshops at the KölnerKinderUni! Future scientists aged 8 to 12 learned in hands-on experiments how the uniqueness of individuals is encoded in the DNA🧬
A big thank you to Lara, Lilli and Eileen for making it all happen!
#KKU2025 #ScienceForKids

21.03.2025 14:28 — 👍 4    🔁 0    💬 0    📌 0