Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing.
Glad to be featured in the Editors’ Highlights!
www.nature.com/articles/s41...
#splicing #cryoEM
10.07.2025 14:29 — 👍 68 🔁 21 💬 1 📌 0
See also this nice piece of article created by the LMB news team on our work
www2.mrc-lmb.cam.ac.uk/how-recql5-a...
07.07.2025 14:00 — 👍 1 🔁 0 💬 0 📌 0
Special thanks to Dimitris Typas for his efficient and thoughtful handling of our manuscript and the reviewers constructive feedbacks to help us improve the manuscript.
07.07.2025 14:00 — 👍 0 🔁 0 💬 1 📌 0
YouTube video by MRC Laboratory of Molecular Biology
From the scientist's view: a conversation with David Barford
“If you’re really curious about science, then you should do it.”
We recently caught up with David Barford, Group Leader in the LMB’s Structural Studies Division, to learn more about his career, what inspires him and his group’s research into kinetochore complexes.
youtu.be/qaudt961iMU
03.04.2025 14:42 — 👍 10 🔁 3 💬 0 📌 0
Thank you, Claudio!!
25.03.2025 21:20 — 👍 1 🔁 0 💬 0 📌 0
Thank you, Rob!
24.03.2025 18:45 — 👍 1 🔁 0 💬 0 📌 0
Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein.
www.biorxiv.org/content/10.1...
#cryoEM #transcription #splicing
24.03.2025 15:56 — 👍 50 🔁 20 💬 3 📌 0
🚨 PostDoc opportunity at the MRC-LMB 🚨Join our team to explore transcription-coupled splicing using cryoEM and biochemistry! 🔬🧬
Please spread the news 🙏🏼
Apply here: mrc.tal.net/vx/mobile-0/...
#Postdoc #CryoEM #MolecularBiology
18.03.2025 14:06 — 👍 6 🔁 8 💬 0 📌 1
Thank you, Eugene!
03.02.2025 23:03 — 👍 0 🔁 0 💬 0 📌 0
Thank you, Jan!
03.02.2025 23:03 — 👍 0 🔁 0 💬 0 📌 0
Thank you, Rob!
03.02.2025 20:15 — 👍 0 🔁 0 💬 0 📌 0
See also the beautiful work from the @nogaleslab.bsky.social on RECQL5 www.biorxiv.org/content/10.1...
03.02.2025 12:23 — 👍 2 🔁 0 💬 0 📌 0
Great work by my fantastic first PhD student Helen Zhang as a collaboration started with @anatv.bsky.social , with support from our lab manager Yuliya Gordiyenko and the amazing mass spec facility @mrclmb.bsky.social Tomos Morgan and @catfranco.bsky.social
03.02.2025 12:23 — 👍 2 🔁 0 💬 1 📌 0
Ever wondered how Pol II speed is controlled during productive elongation?
Our study reveals that the helicase RECQL5 triggers transcription braking, while the transcription-coupled DNA repair complex restores the elongation rate. #cryoEM #transcription
www.biorxiv.org/content/10.1...
03.02.2025 12:23 — 👍 77 🔁 18 💬 4 📌 4
Senior editor @naturesmb.bsky.social. Views and opinions are personal.
Assistant Prof at Utrecht University, studying the process of transcription elongation vs early termination. (she/her)
Cryo-EM ❄️🔬 | Molecular machines & mechanisms 🧬 | Associate professor @oxfordbiochemistry ghilarovlab.com
Program Leader and Head of PNAC division at MRC Laboratory of Molecular Biology, Cambridge, UK @mrclmb.bsky.social. Synthetic / Chemical biology and all things RNA
Assistant Professor at the University of Virginia, Biochemist, Molecular and Structural Biologist, Husband, Father, Traveller
#cryoem #ribosome #rna
med.virginia.edu/jomaa-lab/
Professor of RNA Biology FBMH University of Manchester
Molecular geneticist interested in RNA regulation in the brain using mighty Drosophila fruit flies
Epitranscriptomics Phylogenomics Neuro-connectomics ELAV Dscam Sex-peptide Synapse
www.sollerlab.org
Assistant professor at Tufts University studying molecular mechanisms of synapse function. Views my own. https://www.bygravelab.com
Assistant Professor @ UCSF https://www.gunalab.org/
Assistant Professor at the University of Michigan Medical School and @umlifesciences.bsky.social
#cryoEM #RNA #Ribosomes #RNAsky #RNABiology #Science
https://www.lsi.umich.edu/science/our-labs/brito-querido-lab
Studying ribosomes at UT Southwestern
Professor of Genetics
Department of Biochemistry
University of Oxford
kloselab.co.uk
Bacterial pathogenesis. Antibiotic discovery. Membrane remodelling. Structural biology #cryoEM @Imperial College, London thelowlab.org
Senior editor @science.org. Molecular biology, #DNA, #RNA, #gene regulation, #epigenetics, nuclear biology, #chromatin biology, 3D #genome, #synbio, #CRISPR and gene editing, other bacterial immune systems, and #AI in all these
Joint Head of Structural Studies at @mrclmb.bsky.social. Develops & uses #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.
Lise Meitner Research Group Leader @ Max Planck Institute for Multidisciplinary Sciences
Genome Organisation and Regulation
She/her
RNA biologist, climate activist, and forest person. Director of Yale Center for RNA Science and Medicine.
🎥 https://boxd.it/1Ek8z
A lab at the MRC LMB, Cambridge. Interested in dynein, microtubules, cytoskeleton, electron microscopy and much more.
Group Leader @MRC_LMB /Structural Biologist/Biochemist. Amateur baker in free time #RNAworld #spliceosome #telomerase #telomeres #cryoEM #Xraycrystallography
The Nogales Lab @ UC Berkeley. #CryoEM #Transcription #Microtubules #ChromatinModification Bluesky account managed by lab members.
