David Harrison

I completely agree that if this was entirely driven by a reduction in vasopressors then this is more of a process measure than a patient centred outcome, but the supplement suggests ventilation and RRT were also reduced

It didn’t change mortality but reduced organ support by 1 day. Is this not a concrete outcome?

If we design trials to detect superiority based on P<0.05, should we then throw them out as not sufficiently convincing because P=0.04?

I’d be more concerned whether this is showing the benefit of a complex CRT protocol or a clinician at the bedside.

I don’t think it was site selection, although some of our best recruiting sites were maybe in somewhat less diverse parts of the country. Interesting to reflect on whether there was any lack of equipoise.

Interesting point, Jack. If it reflected the UK population of ventilated patients (see supplement) we’d have expected more like 500 black patients so yes, somewhat under-represented but we would not have anticipated large numbers.

Conservative Oxygen Therapy With Mechanical Ventilation This randomized clinical trial assesses whether reducing supplemental oxygen to a peripheral oxygen saturation target of 90% would reduce mortality among critically ill adults receiving mechanical ven...

16,500 patients randomised to #UKROXTrial presented just now at #CCR25 and simultaneously published in @jama.com

No difference in 90d mortality between target SpO2 88-92 with reduced exposure to supplemental O2 vs usual care

jamanetwork.com/journals/jam...

UK-ROx: No harm (or benefit) from a conservative oxygenation strategy in 16,500 mechanically ventilated critically ill adults. #CCR25

Figure 2. Oxygen Exposure and Arterial Oxygenation by Treatment Group in Patients With Enhanced Data Collection

Conservative oxygen therapy with a target SpO2 of 90% did not reduce 90-day all-cause mortality compared to usual oxygen therapy in mechanically ventilated adult patients.

#CCR25 @criticalcarereviews.com

https://ja.ma/4kG5gWK

Professor Dan Martin presenting the UK - ROX trial at Critical Care Reviews 2025

Here we go… #UKROXtrial #CCR25

Three healthcare professionals in scrubs collaborate around a glass wall covered in colourful sticky notes.

Calling all UK-based healthcare professionals who have undertaken a quality improvement project! Share your experiences with us and help us to develop new approaches. Certificates of participation offered. Find out more and fill out the short survey ths.im/3SUUwHG

CCR25 Critical Care Reviews Meeting 2025, Titanic Belfast, June 11th to 13th. Featuring 12 major critical care trial results

Try criticalcarereviews.com/meetings/ccr25

Flyer for the UK-ROX trial results presentation at #CCR25

🚨UK-ROX TRIAL Results at #CCR25🚨

📍 ~100 🇬🇧 ICUs
👥 ~16,500 pts
🎯 Conservative vs usual oxygen therapy in invasively ventilated adults
🩺 Outcome: Mortality day 90

🤔 Will less oxygen save lives?

📺 Free livestream — but it's better in person!
🔗 criticalcarereviews.com/ccr25

The Society and the Faculty of Intensive Care Medicine (FICM) are updating the Guidelines for the Provision of Intensive Care Services (GPICS).

The consultation period for Version 3 is now open and we would value your feedback on the proposed changes.

Read more and take part below👇

bit.ly/GPICSv3

Shocked to wake up to this news. Condolences to Rinaldo’s family and friends, and all our friends and colleagues in the ANZICS community. Vale Rinaldo.

Every 10 seconds vaccination saves a life. Immunization for all is Humanly Possible

It’s #WorldImmunizationWeek

Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.

A reminder of what is #HumanlyPossible. Science saves lives.

#VaccinesWork
bit.ly/wiw2025

Perfect demonstration of why a control is essential…

Text reads: Principles of sharing clinical trial results with participants. 1. Trial teams should pro-actively offer overall study results to all clinical trial participants, irrespective of what the results show. 2. Participants should be given the choice of whether to receive research results. 3. Results should be offered to participants in a timely manner. 4. Trial teams should manage participants’ expectations around when the results will be available. 5. Results should be offered in a way that is accessible to participants, both in terms of the communication mechanism and the content. 6. Patient and public involvement is essential in sharing results with participants. 7. Sharing results with participants requires resources. 8. Consideration needs to be given to potential barriers/challenges to sharing results with participants from the planning stage of the study.

People who take part in #ClinicalTrials and other research have a right to know the results of these studies.

Our 8 principles aim to improve the sharing of trial results with participants. They were developed alongside UK clinical research funders.

More details👉 buff.ly/SGrmL7o

I think you’ll find 22/7 is a much more rational date to celebrate #piday

Invitation to a Two-Round Delphi Study on Sample Size Reporting in Trial Grant Applications and Protocols for Adaptive Designs!

Click the link below to participate 👏:
docs.google.com/forms/d/e/1F...

Or directly contact: qzhang104@sheffield.ac.uk.

Hype, hallucination, hope – what might AI mean for our health? In our fifth REAL Challenge annual lecture, Hetan Shah will warn of the risk of rushing breathlessly to unleash technology. He will explore how policymakers can navigate the hype and critically assess...

I'm honoured to have been asked to give this year's @healthfoundation.bsky.social annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested www.health.org.uk/events/hype-...

Royal College of Anaesthetists Centre for Research and Improvement Director

The College is seeking applications for the position of Director of our Centre for Research and Improvement, which oversees delivery of all College research projects.

An exciting opportunity to play a vital role in our research and improvement work.

ow.ly/A47350UQfxx @rcoa-cri.bsky.social

Severity of Impaired Oxygenation and Conservative... : Pediatric Critical Care Medicine 2% was associated with a shorter duration of organ support and greater survival, compared with Spo2 greater than 94%, in mechanically ventilated children following unplanned admission to PICU. We inve...

Post-hoc analysis of Oxy-PICU by baseline severity of gas exchange - no detectable heterogeneity of treatment effect.

journals.lww.com/pccmjournal/...

Longer-term survival, quality of life, and cost-effectiveness of conservative versus liberal oxygenation targets in critically ill children: a pre-specified analysis from Oxy-PICU, a multicentre, open... Peripheral oxygen saturation (SpO2) above 94% is typical in children in paediatric intensive critical care units (PICUs) who are receiving invasive ve…

1 year follow-up and health economics of Oxy-PICU.
All point estimates still favour conservative oxygenation but differences are not statistically significant with the slightly smaller sample size.

www.sciencedirect.com/science/arti...

But seriously, while some of us care a lot about this, the evidence (not least the latest update to the Declaration of Helsinki) suggests others less so

Are you just goading @statsepi.bsky.social here?

I’ll drop you a message @lawtontri.bsky.social

The third trial result for #CCR25 in Titanic Belfast in June is the UK-Rox Trial

Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU

Register via the QR code or on the CCR website
criticalcarereviews.com/meetings/ccr25

The second trial result for #CCR25 in Titanic Belfast
in June is GASTROSAM

Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition

Join us in June for the best critical care trials in the world

Register at criticalcarereviews.com/meetings/ccr25

Designing an adaptive platform trial with parents, young people and PICU staff in a NIHR accelerator grant. Here’s how we did it and what the platform should look like: bmjopen.bmj.com/content/15/1... @nihr.bsky.social @trakmitch.bsky.social @lyvonnetume.bsky.social @liverpooluni.bsky.social

Why probability probably doesn’t exist (but it is useful to act like it does) All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.

All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is. 🧪

www.nature.com/articles/d41...