Across the full range, it translated to more false negatives, which is the main clinical implication.
15.01.2026 17:49 — 👍 1 🔁 0 💬 0 📌 0Across the full range, it translated to more false negatives, which is the main clinical implication.
15.01.2026 17:49 — 👍 1 🔁 0 💬 0 📌 0At lower saturations, this translated to greater over-estimation of SaO2 (consistent with historical papers). At higher saturations, it translated to less under-estimation (as seen in the preprint, where SaO2s were generally high).
15.01.2026 17:49 — 👍 1 🔁 0 💬 1 📌 0I think our new study actually bridges the gap between the previous evidence and the FDA-funded preprint. The consistent message we found was that the devices, on average, gave higher readings on darker skin tones.
15.01.2026 17:49 — 👍 1 🔁 0 💬 1 📌 0
Fantastic to see this published at last
An objective assessment of the efficacy of home pulse oximeters on different skin tones
Ping @iwashyna.bsky.social
Open to comments from all #foamed #medsky
www.bmj.com/content/392/...
🎄 On the fourth day of Christmas CCR brings to thee
🎁 Four thousand seven hundred children
🎅 No routine gastric residuals measured routinely
🎶 And a partridge in a pear tree
#CCR26
criticalcarereviews.com/meetings/ccr26
Delighted to share details of @nihr.bsky.social James Lind Alliance research priority setting survey for delirium. For completion by UK health/social professionals and those with personal experience of delirium.
Complete the survey and have your say. More details 👇
www.qmul.ac.uk/wiph/centres...
I completely agree that if this was entirely driven by a reduction in vasopressors then this is more of a process measure than a patient centred outcome, but the supplement suggests ventilation and RRT were also reduced
29.10.2025 18:48 — 👍 1 🔁 0 💬 0 📌 0It didn’t change mortality but reduced organ support by 1 day. Is this not a concrete outcome?
29.10.2025 17:53 — 👍 0 🔁 0 💬 1 📌 0
If we design trials to detect superiority based on P<0.05, should we then throw them out as not sufficiently convincing because P=0.04?
I’d be more concerned whether this is showing the benefit of a complex CRT protocol or a clinician at the bedside.
I don’t think it was site selection, although some of our best recruiting sites were maybe in somewhat less diverse parts of the country. Interesting to reflect on whether there was any lack of equipoise.
12.06.2025 11:15 — 👍 3 🔁 0 💬 3 📌 0Interesting point, Jack. If it reflected the UK population of ventilated patients (see supplement) we’d have expected more like 500 black patients so yes, somewhat under-represented but we would not have anticipated large numbers.
12.06.2025 11:15 — 👍 1 🔁 0 💬 1 📌 0
16,500 patients randomised to #UKROXTrial presented just now at #CCR25 and simultaneously published in @jama.com
No difference in 90d mortality between target SpO2 88-92 with reduced exposure to supplemental O2 vs usual care
jamanetwork.com/journals/jam...
UK-ROx: No harm (or benefit) from a conservative oxygenation strategy in 16,500 mechanically ventilated critically ill adults. #CCR25
12.06.2025 08:51 — 👍 2 🔁 1 💬 0 📌 1
Figure 2. Oxygen Exposure and Arterial Oxygenation by Treatment Group in Patients With Enhanced Data Collection
Conservative oxygen therapy with a target SpO2 of 90% did not reduce 90-day all-cause mortality compared to usual oxygen therapy in mechanically ventilated adult patients.
#CCR25 @criticalcarereviews.com
https://ja.ma/4kG5gWK
Professor Dan Martin presenting the UK - ROX trial at Critical Care Reviews 2025
Here we go… #UKROXtrial #CCR25
12.06.2025 08:04 — 👍 9 🔁 1 💬 0 📌 0
Three healthcare professionals in scrubs collaborate around a glass wall covered in colourful sticky notes.
Calling all UK-based healthcare professionals who have undertaken a quality improvement project! Share your experiences with us and help us to develop new approaches. Certificates of participation offered. Find out more and fill out the short survey ths.im/3SUUwHG
03.06.2025 08:03 — 👍 3 🔁 4 💬 0 📌 1
Flyer for the UK-ROX trial results presentation at #CCR25
🚨UK-ROX TRIAL Results at #CCR25🚨
📍 ~100 🇬🇧 ICUs
👥 ~16,500 pts
🎯 Conservative vs usual oxygen therapy in invasively ventilated adults
🩺 Outcome: Mortality day 90
🤔 Will less oxygen save lives?
📺 Free livestream — but it's better in person!
🔗 criticalcarereviews.com/ccr25
The Society and the Faculty of Intensive Care Medicine (FICM) are updating the Guidelines for the Provision of Intensive Care Services (GPICS).
The consultation period for Version 3 is now open and we would value your feedback on the proposed changes.
Read more and take part below👇
bit.ly/GPICSv3
Shocked to wake up to this news. Condolences to Rinaldo’s family and friends, and all our friends and colleagues in the ANZICS community. Vale Rinaldo.
07.05.2025 06:50 — 👍 3 🔁 0 💬 0 📌 0
Every 10 seconds vaccination saves a life. Immunization for all is Humanly Possible
It’s #WorldImmunizationWeek
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
Perfect demonstration of why a control is essential…
17.04.2025 13:09 — 👍 3 🔁 0 💬 2 📌 0
Text reads: Principles of sharing clinical trial results with participants. 1. Trial teams should pro-actively offer overall study results to all clinical trial participants, irrespective of what the results show. 2. Participants should be given the choice of whether to receive research results. 3. Results should be offered to participants in a timely manner. 4. Trial teams should manage participants’ expectations around when the results will be available. 5. Results should be offered in a way that is accessible to participants, both in terms of the communication mechanism and the content. 6. Patient and public involvement is essential in sharing results with participants. 7. Sharing results with participants requires resources. 8. Consideration needs to be given to potential barriers/challenges to sharing results with participants from the planning stage of the study.
People who take part in #ClinicalTrials and other research have a right to know the results of these studies.
Our 8 principles aim to improve the sharing of trial results with participants. They were developed alongside UK clinical research funders.
More details👉 buff.ly/SGrmL7o
I think you’ll find 22/7 is a much more rational date to celebrate #piday
14.03.2025 15:27 — 👍 2 🔁 0 💬 1 📌 0
Invitation to a Two-Round Delphi Study on Sample Size Reporting in Trial Grant Applications and Protocols for Adaptive Designs!
Click the link below to participate 👏:
docs.google.com/forms/d/e/1F...
Or directly contact: qzhang104@sheffield.ac.uk.
I'm honoured to have been asked to give this year's @healthfoundation.bsky.social annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested www.health.org.uk/events/hype-...
06.01.2025 08:43 — 👍 55 🔁 20 💬 3 📌 4
Royal College of Anaesthetists Centre for Research and Improvement Director
The College is seeking applications for the position of Director of our Centre for Research and Improvement, which oversees delivery of all College research projects.
An exciting opportunity to play a vital role in our research and improvement work.
ow.ly/A47350UQfxx @rcoa-cri.bsky.social
Post-hoc analysis of Oxy-PICU by baseline severity of gas exchange - no detectable heterogeneity of treatment effect.
journals.lww.com/pccmjournal/...
1 year follow-up and health economics of Oxy-PICU.
All point estimates still favour conservative oxygenation but differences are not statistically significant with the slightly smaller sample size.
www.sciencedirect.com/science/arti...
But seriously, while some of us care a lot about this, the evidence (not least the latest update to the Declaration of Helsinki) suggests others less so
28.01.2025 12:59 — 👍 2 🔁 0 💬 0 📌 0