Sahar

B cells targeting parasites capture spatially linked antigens to secure T cell help Antigen location orchestrates T cell–B cell collaboration in response to large pathogens.

A new #ScienceImmunology study in mice provides insight into why malaria vaccines that contain the whole Plasmodium parasite may have limited efficacy in humans who live in endemic regions. https://scim.ag/4nONXn9

Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis Macrophages are presumed to attack antibody-opsonized cancer cells by phagocytosis. Rollins et al. found that macrophages attack adherent cells using trogo

See study by @kirstin-rollins.bsky.social, @sareenfiaz.bsky.social, Ishwaree Datta and @mmorrissey.bsky.social: rupress.org/jcb/article/...

EGFR Activation and Conformational “Convergence”: An Emerging Allosteric Model From Cancer Mutations Since its isolation nearly 50 years ago, the Epidermal Growth Factor Receptor (EGFR) has become one of the most extensively studied oncogenes. However…

www.sciencedirect.com/science/arti...
sometimes a review is just so good you have to share it

performance anxiety is so silly cuz why is it the one time im observed i mess up in ways ive never had before doing the thing a million times 😬😂

I love finding a paper published years ago (5, 10, 15, 20) that isn't famous or field changing or has a ton of citations but when you read it is just awesome. Like, beautifully designed & executed & written. Best part is that there are so many papers like that lurking in the literature.

this is so cool!!!!

mind blown

Deep Learning for Microscopy Image Analysis Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,

Janelia is hosting a course on DL for bioimage analysis www.janelia.org/you-janelia/...

FPbase Fluorescence Spectra Viewer An interactive fluorescence spectra viewer to evaluate the spectral properties of fluorescent proteins, organic dyes, filters, and detectors.

The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!

www.fpbase.org/spectra/

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...

are there any major differences between the features here and thermo's spectra viewer?

Glycosylation in Cancer: From Functional Roles to Therapeutic Implications The field of cancer glycobiology aims to understand how aberrant glycosylation contributes to the development of cancer. While the significance of glycosylation to normal and pathological cellular fun...

Proud of our latest #glycotime review. Co-authored by my amazing cancer collaborator Dr. Eva Hernando and our students @faezehjame.bsky.social , Tigist Batu and Kylie Prutisto-Chang. 🧪
Glycosylation in Cancer: From Functional Roles to Therapeutic Implications - www.annualreviews.org/content/jour...

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression - Nature Communications Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment ...

Dr Donna Senger gave the next talk: Harnessing the power of macrophages for cancer therapy #CCRC2025
- 40% of a glioblastoma tumour can be recruited pro-tumour macrophages!
- inhibiting the expression of nuclear IL-33 reduces this recruitment/transformation
www.nature.com/articles/s41...

cant imagine the sadness at union station tonight 🫠

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...

Microscopy preprints – new tools and techniques in imaging - FocalPlane Microscopy preprints – new tools and techniques in imaging - News

ICYMI – Check out our latest #preprint list on FocalPlane, highlighting the latest tools and techniques in microscopy.
focalplane.biologists.com/2025/10/22/m...

A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

this is so cool!!

I love the GO train cuz you never know which aquaintance you'll randomly meet by pure chance

How to develop good research questions

"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."

www.nature.com/articles/s41...

👏👏

5-color STORM with a single laser using cos/sin filters and phasor plots: www.biorxiv.org/content/10.1...
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!

Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...

whats the name of a graph like this for looking at phosphorylation?

Golden Sky
6”x6” oil
Available

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!

Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.

See here:
www.sciencedirect.com/science/arti...

Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...

Target cell adhesion limits macrophage #phagocytosis and promotes #trogocytosis, say @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al.
@ucsantabarbara.bsky.social rupress.org/jcb/article/...

#Macrophages #Immunology

Improved whole-mount immunofluorescence protocol for consistent and robust labeling of adult Drosophila melanogaster adipose tissue Summary: Optimization of adult Drosophila fat body fluorescence microscopy via modifications of tissue handling, fixation, and permeabilization steps in a whole-mount immunolabeling protocol.

Protocol is linked here :)

wondering the same!