Nathalie M. Grob

Hijacking a bacterial ABC transporter for genetic code expansion - Nature Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...

🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...

it all started years ago with a failed experiment
🧵👇 1/9

Late-Stage Diversification of Native Tryptophan-containing Peptides and Peptide Drugs through Nitrogen Atom Insertion Peptide drugs are a powerful modality in modern drug dis-covery. Synthetic methods that enable the late-stage diversifi-cation of native peptides through amino acid-specific modifi-cations are thus in...

We are thrilled to share our first preprint on ChemRxiv! Together with @morandilab.bsky.social, we applied nitrogen atom insertion to Trp-containing peptides for late-stage modification. A big thanks to Ann-Sophie, Eva, Masota, and Florin for their outstanding contributions! doi.org/10.26434/che...

PhD Position in Peptide-Based Drug Discovery (Industry Collaboration, w/m/d)

We are hiring! Check out our open PhD position for an exciting industry collaboration with Novo Nordisk:
jobs.ethz.ch/job/view/JOP...

My team and I had a blast at the 2025 Peptide Therapeutics Forum in Basel with inspiring talks from our national and international colleagues and engaging discussions during the poster sessions. Thanks to the @swisschemistry.bsky.social for the generous support! #PTF2025

portrait pictures of the confirmed speakers for the peptide therapeutics forum 2025

Only a few more days to register for the 2025 Peptide Therapeutics forum! Join us in Basel on June 05–06 for a firework of peptide chemistry and peptide drug development.

ptf25.scg.ch

Exciting PhD opportunity at the intersection of machine learning and chemistry!

Peptide Therapeutics Forum 2025 - Last Chance to submit your abstract for a talk!
@biozentrum.unibas.ch

‼️Submit your abstract today via ptf25.scg.ch/registration
#ptf25 #scs #medchem #switzerland #symposia

Prof. Nina Hartrampf in front of the lecture room showing the acknowledgment slide of her presentation.

Today I had the pleasure of hosting @ninahartrampf.bsky.social as a speaker in the Seminars on Drug Discovery and Development. Thank you for a fantastic talk and inspiring conversations with the members of our institute!

Peptide-based drugs without borders Peptides act as signal mediators in the body and are on the rise as therapeutic agents. However, their full potential can often be limited by rapid degradation and elimination. Nathalie Grob, the new ...

Do you want to know more about peptide-based drug discovery and the mission of my research team at ETH? Check out the article on our department’s website:
chab.ethz.ch/en/news-and-...

A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins Solid-phase peptide synthesis (SPPS) and native chemical ligation (NCL) are powerful methods for obtaining peptides and proteins that are otherwise inaccessible. Nonetheless, numerous sequences are di...

Our Synthesis Tag (SynTag) for the synthesis of aggregating peptides and proteins is now published in JACS 🥳 Congratulations to first authors Héloïse & Elyse and everyone else involved ✨✨

pubs.acs.org/doi/10.1021/...

Postdoc position in reactive machine learning potentials

What better first post than to advertise this position. Come join our group!

Our group is recruiting a postdoctoral researcher for a project on reactive machine learning potentials. Reposts and spreading the word to interested people in your network appreciated!

jobs.ethz.ch/job/view/JOP...

Happy to see my Medicinal Chemistry and Chemical Biology Highlight out in the current CHIMIA and online. Thank you to @klanglab.bsky.social for the invitation!
www.chimia.ch/chimia/artic...

Homepage

Are you curious to see what my team and I are up to? Check out our group website here: peptide-discovery.ethz.ch