Ahmad Ali

Both #Cancer #Research starter packs are now completely full!

~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️

I hope you'll find these useful to build our community here

Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA

23.11.2024 13:27 — 👍 240    🔁 88    💬 32    📌 6

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG

11.02.2025 09:57 — 👍 49    🔁 19    💬 6    📌 1

Valeros et al, Rhodoquinone carries electrons in the mammalian electron transport chain

Groundbreaking week of research in #mitochondrialdisease!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitowomen.bsky.social @mitoworld.bsky.social

Rhodoquinone carries electrons in the mammalian electron transport chain

09.02.2025 09:17 — 👍 22    🔁 15    💬 0    📌 0

a man in a suit sits at a desk in front of a bookshelf with the word rec on it ALT: a man in a suit sits at a desk in front of a bookshelf with the word rec on it

Good Sunday, all! There are so many exciting discoveries in #cancermetaboilism and #mitochondrialbiology this week!! Don't miss them, find them here:
biomed.news/bims-camemi/... @biomednews.bsky.social

If you are patient in one moment of anger, you will escape 100 days of sorrow. Chinese proverb

09.02.2025 06:24 — 👍 26    🔁 13    💬 1    📌 0

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

08.02.2025 21:21 — 👍 1017    🔁 863    💬 82    📌 32

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctiona...

A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6
www.science.org/doi/10.1126/...

06.02.2025 21:22 — 👍 74    🔁 30    💬 9    📌 3

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

New from the Rabinowitz lab “Lactate homeostasis is maintained through regulation of glycolysis and lipolysis” www.cell.com/cell-metabol...

03.02.2025 11:54 — 👍 8    🔁 2    💬 0    📌 0

Many Thanks

05.02.2025 18:10 — 👍 1    🔁 0    💬 0    📌 0

Could you please provide us with any online link if available?

05.02.2025 16:46 — 👍 0    🔁 0    💬 1    📌 0

Crazy that I defended yesterday. My journey had its challenges—late nights, self-doubt, and balancing academics with personal life. Each obstacle taught me resilience and time management. I’m grateful to my friends, family, and mentors for their unwavering support. A big hug to all who stood by me.

31.01.2025 21:05 — 👍 0    🔁 0    💬 0    📌 0

The journey of academic growth is one of constant evolution, marked by milestones that test your resilience and adaptability. For many scholars, the transition from one academic environment to another—especially when seeking a postdoctoral position—is a defining moment.

26.01.2025 23:02 — 👍 0    🔁 0    💬 0    📌 0