Pierre Mégevand

Association between Interictal Spike Rate and Seizure Frequency in a Large Epilepsy Cohort Importance: Tracking and predicting seizure frequency in patients with epilepsy is important for prognostication and therapy management. Interictal spikes have been proposed as a biomarker of seizure ...

"Association between Interictal Spike Rate and Seizure Frequency in a Large Epilepsy Cohort"

From the abstract: "Overall, spike frequency was modestly associated with seizure frequency".

#medRxiv #preprint #EEG #neuroskyence #MedSky

www.medrxiv.org/content/10.6...

Experimental task. Trials began with variable fixation (500–1,000 ms) and placeholder (500–1,000 ms) intervals, followed by two spatial cues (100 ms) on opposite sides of the visual field to indicate the likely locations of both a subsequent near-threshold target and a salient distractor (100 ms). Cue validity was 70% for both cue types. Targets and distractors were presented after a variable delay (500–1,600 ms). Stimulus displays could include (i) both a target and a distractor, (ii) a target only, (iii) a distractor only, or (iv) neither a target nor a distractor. The number pad on a computer keyboard was used to indicate the presence of a target at the cued location, a target at a non-cued location, or no target.

Attentional resources vary rhythmically, but what about susceptibility to #distractors?@fiebelkornian.bsky.social &co show that theta & alpha phases modulate sensitivity & distractor impact, revealing rhythm-specific mechanisms shaping #attention & distractability @plosbiology.org 🧪 plos.io/4tU0vh4

Postdoctoral researcher on single neuron recordings for consciousness Contract period: 18 monthsExpected date of employment: June 2026Proportion of work: Full timeSalary: according to INSERM scales (~2900 – 3300 € gross / month based on experience)Desired level of educa...

#hiring
Come work with us to better understand the neuronal mechanism underlying perceptual consciousness!

18 months postdoctoral position at INSERM in Grenoble, France.

⌛Application deadline 10 March 2026.

euraxess.ec.europa.eu/jobs/408445

Temporal order of activations and interactions during arithmetic calculations measured by intracranial electrophysiological recordings in the human brain - Scientific Reports Arithmetic requires complex and fast processes orchestrated within a large-scale network spanning multiple brain regions. However, reports on the network’s temporal dynamics are scarce. Here, we prese...

"Temporal order of activations and interactions during arithmetic calculations measured by intracranial electrophysiological recordings in the human brain"

in #ScientificReports

#iEEG #SEEG

doi.org/10.1038/s415...

Oscillatory and gaze signatures of socio-emotional speech processing, visuo-spatial cognition, and their interaction in a near-realistic dual-task MEG study https://pubmed.ncbi.nlm.nih.gov/41717383/

Please get him off LinkedIn...

<em>Psychophysiology</em> | SPR Journal | Wiley Online Library Electroencephalography (EEG) studies of the perception of emotional speech indicate that early components of event-related brain potentials (ERPs) are modulated by emotion. However, the direction and...

Acoustic Features of Emotional Vocalizations Account for Early Modulations of ERPs onlinelibrary.wiley.com/doi/10.1111/... "We conclude that acoustic features can account for early ERP modulations ...Because previous studies used a variety of stimuli, our result likely resolves previous disputes"

Which is worse, the liar who lied or the Senators who knew he was lying and used the lie to excuse their vote to confirm the liar?

This is true regardless of whether 5 or 50% of research grants are funded, though. Hence the Swiss national science foundation's decision to draw lots for applications ranked near the funding limit.

Look where we are, EU. 💀

We constantly talk about promoting science, increasing the investment in science, having a technology-driven economy, surpassing the US and China with modern tools. The image below is the evaluation report from a friend, who did not get a #MSCA grant despite scoring 94.4%.

We still do. But funding cuts and record numbers of applications mean that success rates will drop already this year. Not yet to 5%, but probably 10-15%.

"The hapless Swiss"

This reminds me of the end-game screen of Civilization when things had not gone so well.

The hapless Swiss
The puny Corinthians
The miserable Prussians

Parkinson’s disease as a somato-cognitive action network disorder - Nature The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

In case this important point gets overlooked: along with our Nature paper, we’ve publicly released two large and scarce datasets—PIPD and PIET. IMHO, these are the best open Parkinson's and Tremor datasets available to date.
See threads (1/4) 👇
nature.com/articles/s41...

GM: Charisma check.

Mamdani: [rolls natural 20]

GM: that’s a d6 how did you

Mamdani: [direct to camera] Did you know you can check out board games at your local public library? 😊

Is it an outrage if your NIH grant score goes from nearly funded to ND after you revise it? Yes, the answer is yes. It is extremely painful to have your grant proposal just miss the cut for funding on one version and then to have the revised version end up way out of the race or Not Discu…

Is it an outrage if your NIH grant score goes from nearly funded to ND after you revise it? drugmonkey.wordpress.com/2026/02/06/i...

A large stuffed folder of files with the title “Epstein” is seen with what looks, at first glance, like a red page marker sticking out of the bottom. On closer inspection it is the bottom of a Trump red neck tie. French newspapers once again showing the kind of basic journalistic integrity lacking from most US national newspapers - whose collective negligence has helped ensure a man implicated in the world’s most notorious sex trafficking ring gets to remain President. That the orange pedo felon remains in office is a plague on all their houses. Cunts, one and all.

The cartoon that appeared this week on the front page of France’s most influential national newspaper, Le Monde

Brilliant work by the cartoonist, Guffo.

Reporter: Do any of you have a favorite animal?

Child: My favorite one is a gold snake that can move. It has gold eyes, and it has a super-duper tail…

Reporter: Mr. Mamdani, the second question for you.

Mamdani: Yes. It’s also the golden snake.

We’re hiring! The Suthana Lab @ Duke is looking for a Research Assistant to join our team studying human memory & real-world 🧠 dynamics using wearable tech & intracranial recordings.

Apply: careers.duke.edu/job/Durham-C...

You can also email suthanalab@duke.edu with CV/questions. Please share!

During a dive last year in the Atlantic Ocean off Argentina, researchers documented a giant phantom jelly, a deep-sea species rarely seen since it was discovered a little over a century ago. “There was a mixture of excitement and disbelief,” said one marine biologist. trib.al/HfkWfp4

Comic. [Person talking to person with black hat.] PERSON 1: Historically, it refers to a ceremony to predict the weather using a rodent. But nowadays people often use it to mean “a time loop experienced by one person.” PERSON 2: …What. [caption] Easily our weirdest holiday.

Groundhog Day Meaning

xkcd.com/3202/

Thank you for The kind words David, looking forward to working with you on this!

Great opportunity for important work and training! I hope to collaborate closely with Nina and Pierre on this innovative cog sci/ cog neuro project. #neuroskyence

Résultat expérimental. Les tirages ne font pas mieux que le hasard

16/25

Voyons maintenant les 843 résultats expérimentaux au bout de 2 ans d'expérience.

Les meilleurs représentants de la discipline, des sourciers qui avaient tous validé le protocole expérimental, forts de leur expérience... ne font pas mieux que s'ils tiraient au hasard les positions prédites.

Trump, Changing Course, Throws Harvard Deal Talks Into Chaos

What did they say about negotiating with bullies?

www.nytimes.com/2026/02/03/u...

Et son adversaire s'appelait Wambsganss #Succession

Boulet parle des blogs, et un vieux gars intervient Boulet: un truc qui était bien au début de cette période "les blogs", c'est que tout le monde s'en foutait. Vieux gars: Pfff vos trucs d'INTERNET, là ! Ça ne remplacera jamais le PAPIER ! B: Oui mais non, c'est pas le but, c'est juste que... VG (interrompant): Moi je suis attaché à L'OBJET ! J'ai besoin de TOUCHER ! B: Certes, mais… VG (reniflant exagérément): Je veux sentir les pages TOURNER sous mes doigts, et L'ODEUUUR du VIEUX PAPIER VG (Attrapant Boulet par le col, l'air dément, transpirant): Et comment tu RANGES ÇA DANS TA BIBLIOTHÈQUE, hein ? B (un peu nerveux): Non mais je dis pas mais … VG: Comment tu le PRÊTES À UN AMI ? Le vieux gars s'éloigne, furieux, les bras gesticulant encore Boulet, confus, tente un dernier "Je..." VG: Comment tu frottes la tranche sur ton corps nu ? Comment tu pinces ton sexe entre les pages en appuyant à deux mains ?

Aussi Facebook m'a ressorti ce banger d'il y a 10 ans.

Is there any blog by an experienced emergency physician who is not immensely sour about, like, everything?

a cartoon character says " omelette du fromage " in a foreign language ALT: a cartoon character says " omelette du fromage " in a foreign language

Omelette du fromage!

#DextersLab

Nice! Fond memories of the rodent whisker system / barrel cortex

Secondary Somatosensory Cortex Is Required for Learning but Not Execution of a Tactile Discrimination The relationship between primary somatosensory cortex (S1) and secondary somatosensory cortex (S2) during learning is not clear. Here, we show that when confronted with a texture discrimination using...

OUT NOW🧠🐭
New work shows that secondary somatosensory cortex (S2) is essential for learning a whisker-based tactile discrimination—but not for executing it once learned.
onlinelibrary.wiley.com/doi/10.1111/...