Anna-Jayne Metcalfe πŸ³οΈβ€βš§οΈ's Avatar

Anna-Jayne Metcalfe πŸ³οΈβ€βš§οΈ

@anna-jayne.bsky.social

C++ #programmer, #aerialyoga nerd, #TDoR case research volunteer & owner of a lonely halberd. Bournemouth, UK https://www.riverblade.co https://www.annasplace.me.uk [CN] https://tdor.translivesmatter.info #Trans. She/her/trouble

637 Followers  |  883 Following  |  200 Posts  |  Joined: 20.11.2024
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Posts by Anna-Jayne Metcalfe πŸ³οΈβ€βš§οΈ (@anna-jayne.bsky.social)

This is the candidate who campaigned in Urdu, and who appealed to the communal fury of Muslim voters, inviting them to β€œPunish Labour for Gaza”. Let’s not forget she also engaged in a bit of the old dog-whistling by appearing in a video showing Keir Starmer shaking hands with Indian PM Narendra Modi. Translation: you can’t trust Sir Keir – he hangs out with dodgy Hindus.

This is the candidate who campaigned in Urdu, and who appealed to the communal fury of Muslim voters, inviting them to β€œPunish Labour for Gaza”. Let’s not forget she also engaged in a bit of the old dog-whistling by appearing in a video showing Keir Starmer shaking hands with Indian PM Narendra Modi. Translation: you can’t trust Sir Keir – he hangs out with dodgy Hindus.

I don’t think the UK is going to do okay when every day we’re exposed to media that treats us like we’re fundamentally incapable of thought. O’Neill knows he’s bullshitting, we know it, but constant exposure to this moronic mode of thinking hurts all of us

28.02.2026 16:29 β€” πŸ‘ 140    πŸ” 12    πŸ’¬ 4    πŸ“Œ 3
Brendan O'Neill
Hannah Spencer combines the spirit of CBeebies with the politics of Gaza
The new Green MP campaigned in Urdu and appealed to the communal fury of Muslim voters

Brendan O'Neill Hannah Spencer combines the spirit of CBeebies with the politics of Gaza The new Green MP campaigned in Urdu and appealed to the communal fury of Muslim voters

Brendan O'Neill
Published 28 February 2026 8:00am GMT
If Queers for Palestine were a person, it would be Hannah Spencer. No one better sums up the dimness and sheer vacuity of the modern Left than the new MP for Gorton and Denton. There she is in her blue jeans and trendy trainers dancing awkwardly as Muslim men who dream of wrapping her sinful body in a black cloak look on with restrained fury

Brendan O'Neill Published 28 February 2026 8:00am GMT If Queers for Palestine were a person, it would be Hannah Spencer. No one better sums up the dimness and sheer vacuity of the modern Left than the new MP for Gorton and Denton. There she is in her blue jeans and trendy trainers dancing awkwardly as Muslim men who dream of wrapping her sinful body in a black cloak look on with restrained fury

If we’re ever going to get out of this, the British media class must be destroyed

28.02.2026 16:22 β€” πŸ‘ 527    πŸ” 110    πŸ’¬ 40    πŸ“Œ 34

Labour never learns.

Also, maybe don't wear the imperial officer uniform from Star Wars out in public.

28.02.2026 11:28 β€” πŸ‘ 34    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0
Banner showing the following slogan - Stop killing people you fucking twats.

Banner showing the following slogan - Stop killing people you fucking twats.

28.02.2026 12:31 β€” πŸ‘ 121    πŸ” 45    πŸ’¬ 1    πŸ“Œ 1

Yeah they mean to teach the people a lesson instead of taking one and the lesson is Fuck You Cruelty is Good

28.02.2026 12:34 β€” πŸ‘ 89    πŸ” 19    πŸ’¬ 2    πŸ“Œ 0

The world could be such a nice place if we allowed it. It's all so goddamn unnecessary. There's no need for any of it. It's so beautiful here. It should be so cool to be alive

28.02.2026 12:42 β€” πŸ‘ 14291    πŸ” 4440    πŸ’¬ 116    πŸ“Œ 91

Israel, immediately after vaporizing a bunch of little girls:

28.02.2026 12:48 β€” πŸ‘ 7786    πŸ” 2760    πŸ’¬ 55    πŸ“Œ 98

THEY MURDERED 60 KIDS IN AN ELEMENTARY SCHOOL YOU FREAK

28.02.2026 14:30 β€” πŸ‘ 3534    πŸ” 788    πŸ’¬ 19    πŸ“Œ 8

Trump has launched an illegal regime change war.

As someone who has survived the horrors of war, I know military strikes will not make us safer; they will inflame tensions and push the region further into chaos.

When we abandon diplomacy, we choose destruction.

28.02.2026 15:06 β€” πŸ‘ 3598    πŸ” 765    πŸ’¬ 68    πŸ“Œ 11

BBC news editors be like: "Does ANYONE here actually have the phone number for the Greens? Someone must have it surely."

27.02.2026 07:51 β€” πŸ‘ 343    πŸ” 46    πŸ’¬ 7    πŸ“Œ 3

You mean to tell me that after a year and a half of being shat on by the Labour leadership, left wing voters decided to give someone else a go? Labour’s β€œit’s us or reform” message didn’t work because they’ve echoed Reform’s rhetoric since taking power?

Well I never. Who could have seen this coming

27.02.2026 07:53 β€” πŸ‘ 267    πŸ” 46    πŸ’¬ 4    πŸ“Œ 0
Showing results with Green at 40.7% and Labour at 25.4%

Showing results with Green at 40.7% and Labour at 25.4%

Labour adviser: Keir, we need to divide the country to gain votes. It worked so well in the US
Keir: Erm, ok then.

UK Voters:

27.02.2026 07:54 β€” πŸ‘ 23    πŸ” 5    πŸ’¬ 1    πŸ“Œ 2

What a result!! Huge congratulations to the amazing Hannah Spencer - everyone in Gorton and Denton has just made history. This result shows @greenparty.org.uk can win anywhere, that the politics of hope can win over the politics of hate & there is no longer any such thing as a Labour safe seat πŸ’š

27.02.2026 07:02 β€” πŸ‘ 1686    πŸ” 268    πŸ’¬ 35    πŸ“Œ 20
Preview
a man in a green bodysuit is dancing in front of a trailer that says fx on it ALT: a man in a green bodysuit is dancing in front of a trailer that says fx on it

gorton and denton

27.02.2026 04:47 β€” πŸ‘ 234    πŸ” 23    πŸ’¬ 4    πŸ“Œ 1
Post image

BREAKING: Green Party win Gorton and Denton by-election!

27.02.2026 04:35 β€” πŸ‘ 871    πŸ” 163    πŸ’¬ 59    πŸ“Œ 73
Preview
Puberty blockers’ clinical trial paused after concerns from regulator The MHRA will now discuss the concerns, related to the wellbeing of children and young people with gender dysphoria, with trial sponsor King’s College London next week

#transrights

Th whole fucking point it to stop puberty & prevent the kids having to live with damage or pay 10,000s or more undoing it.

www.independent.co.uk/news/health/...

21.02.2026 08:26 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Preview
UK clinical trial into puberty blockers on hold after medicines regulator steps in Recruitment of children for study delayed after MHRA warns that participants should be no younger than 14

So, the idea is only to test puberty blockers on those who have already gone through puberty? Some blatantly Kafkaesque bullshit here.
www.theguardian.com/science/2026...

21.02.2026 06:04 β€” πŸ‘ 101    πŸ” 40    πŸ’¬ 6    πŸ“Œ 10
Preview
One in six children who died by suicide were LGBTQ+, new data shows Amid heated public debate about whether trans children are dying by suicide, campaigners say we need to "take the politics out of policymaking"

The National Child Mortality Database repeatedly refused to tell us what they knew about LGBTQIA+ youth suicides.

But we didn’t give up.

21.02.2026 17:02 β€” πŸ‘ 61    πŸ” 27    πŸ’¬ 3    πŸ“Œ 4

A letter?

Are you fucking kidding me?

From the party that cries, "Oh! The voter fraud is everywhere! We gotta stop it!" WTAF?

HONEY! Your billionaire boo did it & all y'all have is a letter?! Spare me & everyone else your faux outrage about "illegals" voting, you spineless hypocritical bigots.

21.02.2026 17:07 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Genuinely not sure most cis people understand how severe a trans rights crisis this is.
If you are openly trans you face discrimination and daily humiliation. If you are not openly trans you risk being fired if your workplace finds out. That's a huge blackmail vulnerability.

20.02.2026 07:48 β€” πŸ‘ 141    πŸ” 37    πŸ’¬ 1    πŸ“Œ 0

My two cents: Cis editors should be assigning trans reporters to write about trans folks right now.

20.02.2026 13:37 β€” πŸ‘ 524    πŸ” 115    πŸ’¬ 2    πŸ“Œ 3
Dear l
and Team,
CONFIDENTIAL
Subject: Invitation to discuss proposed amendments to Clinical Trial Protocol
1. I write further to the MHRA's letter of 7t November 2025. As you are aware, there is a great deal of public and professional interest in this trial. MHRA keeps under review all of the representations that have been made. I write now to discuss potential amendments that we believe will strengthen the trial protocol.
Implementation of a minimum age restriction
2. We would like to discuss the inclusion of a minimum age for participation in the trial, given the known effects of this agent and the fact that the duration-exposure element of these drugs is significant (adding to the unknown effect of duration-exposure on various stages of Tanner development). Since potentially significant and, as yet, unquantified risk of long-term biological harms is present to participants and biological safety has not been definitively demonstrated in this proposed cohort, at the very least, there should be a graded/stepwise approach starting with those aged 14 as the lower limit of eligibility. Future trials may consider lowering the threshold depending on the findings of the initial trial. From the description of the trial involvement, that for those participants who complete the trial after 2 years but are below the age of 16, it is likely that further GRa treatment could be needed for many years (particularly if participants are significantly below the age of 16 at trial completion) as a bridging measure as cross-sex hormones are only prescribable from the age of 16.
3. There is a risk that broad Tanner stage inclusion introduces heterogeneity that the study is not powered to address.
4. Another factor is that the expected effects of the drugs include the sterilising effect of puberty blockers followed by cross sex hormones and that gamete retrieval to preserve fertility is not possible at the stage when puberty blockers are given (Tanner stage 2) as neither sperm nor ova h…

Dear l and Team, CONFIDENTIAL Subject: Invitation to discuss proposed amendments to Clinical Trial Protocol 1. I write further to the MHRA's letter of 7t November 2025. As you are aware, there is a great deal of public and professional interest in this trial. MHRA keeps under review all of the representations that have been made. I write now to discuss potential amendments that we believe will strengthen the trial protocol. Implementation of a minimum age restriction 2. We would like to discuss the inclusion of a minimum age for participation in the trial, given the known effects of this agent and the fact that the duration-exposure element of these drugs is significant (adding to the unknown effect of duration-exposure on various stages of Tanner development). Since potentially significant and, as yet, unquantified risk of long-term biological harms is present to participants and biological safety has not been definitively demonstrated in this proposed cohort, at the very least, there should be a graded/stepwise approach starting with those aged 14 as the lower limit of eligibility. Future trials may consider lowering the threshold depending on the findings of the initial trial. From the description of the trial involvement, that for those participants who complete the trial after 2 years but are below the age of 16, it is likely that further GRa treatment could be needed for many years (particularly if participants are significantly below the age of 16 at trial completion) as a bridging measure as cross-sex hormones are only prescribable from the age of 16. 3. There is a risk that broad Tanner stage inclusion introduces heterogeneity that the study is not powered to address. 4. Another factor is that the expected effects of the drugs include the sterilising effect of puberty blockers followed by cross sex hormones and that gamete retrieval to preserve fertility is not possible at the stage when puberty blockers are given (Tanner stage 2) as neither sperm nor ova h…

the Secretary of State on the proposed permanent order to restrict the sale and supply of GNRHa in CYP<18 years (dated 13 November 2024)
Recommendation 7 states: "A clear exit strategy needs to be put into place for continuation of GRH agonists when exiting the trial if this is the pathway agreed with the patient and/or parents or carers. This should be accompanied by data collection on the efficacy and safety of the GnRH agonists." For children recruited to the Trial below 14 years of age there will be potentially many years of therapy to bridge to the point of age 16. Therefore, a minimum age of 14 might be a way to avoid a long bridge and will allow any participant in the trial to have all options available to them after the 2 years trial.
Ensuring the full suite of options are available will also allow the trial to assess fully the extent to which participants choose different options and how they are impacted by them.
Suggested Amendment to the Trial Protoco!
Inclusion criteria 4
4. 14 years or older at the time of consent.
Safety monitoring and withdrawal criteria
6. The MHRA recognises that this TIMP is already being used in precocious puberty. However, unlike patients with precocious puberty, the proposed cohort in this trial have normal biological hormonal and sexual development but a psychological condition of gender dysphoria. This of itself would not preclude an off-label use within the confines of a trial. However, the MHRA would like to explore the inclusion of much more detailed physiological safety assessment for this biologically healthy cohort. The statistically powered primary endpoint being presented is the KIDSCREEN10 QOL questionnaire. However, in this situation, the physiological and adverse pharmacological impacts may long outlast and outweigh any QoL detected differences:
(a)
Bone effects- It is recognised that short-term bone effects of triptorelin may sometimes be reversible. However, available data suggests treatment with triptorelin beyo…

the Secretary of State on the proposed permanent order to restrict the sale and supply of GNRHa in CYP<18 years (dated 13 November 2024) Recommendation 7 states: "A clear exit strategy needs to be put into place for continuation of GRH agonists when exiting the trial if this is the pathway agreed with the patient and/or parents or carers. This should be accompanied by data collection on the efficacy and safety of the GnRH agonists." For children recruited to the Trial below 14 years of age there will be potentially many years of therapy to bridge to the point of age 16. Therefore, a minimum age of 14 might be a way to avoid a long bridge and will allow any participant in the trial to have all options available to them after the 2 years trial. Ensuring the full suite of options are available will also allow the trial to assess fully the extent to which participants choose different options and how they are impacted by them. Suggested Amendment to the Trial Protoco! Inclusion criteria 4 4. 14 years or older at the time of consent. Safety monitoring and withdrawal criteria 6. The MHRA recognises that this TIMP is already being used in precocious puberty. However, unlike patients with precocious puberty, the proposed cohort in this trial have normal biological hormonal and sexual development but a psychological condition of gender dysphoria. This of itself would not preclude an off-label use within the confines of a trial. However, the MHRA would like to explore the inclusion of much more detailed physiological safety assessment for this biologically healthy cohort. The statistically powered primary endpoint being presented is the KIDSCREEN10 QOL questionnaire. However, in this situation, the physiological and adverse pharmacological impacts may long outlast and outweigh any QoL detected differences: (a) Bone effects- It is recognised that short-term bone effects of triptorelin may sometimes be reversible. However, available data suggests treatment with triptorelin beyo…

criteria at 12 months if this point is not already clear. See MHRA recommendation below.
(b)
Vaginal bleeding- There is a risk of flare-up effects in very young children who may not be able to report these developments; this is another reason why we suggest a minimum age limit should be introduced. In any event, for all participants we would like to discuss the provision of haematological monitoring, particularly if it persists beyond 2 weeks, as is sometimes seen when this agent is used in endometriosis treatment. Regular haematological monitoring in cases of bleeding beyond 2 weeks is suggested.
Potential loss of fertility- It is widely understood that reduction in gametogenesis will very likely cause infertility in these young people. These are medically consequential effects for a future adult individual that may involve infertility treatment and significant medical interventions. In light of the long term fertility consequences, Gillick Competence for consent as per RCPCH and the Academy of Medical Sciences Guidelines
(academy of medical royal colleges statement on gillick competency fina | 003.pdf) guidance on consent in children under 16 years of age should be sought. We suggest that this should be assessed and documented before consent is obtained using tools such as Gillick Competency checklist (Microsoft Word - Gillick Competence 2016 update.doc). Given the suggested changes, we would expect that an amendment would be submitted to HRA and the REC would want to look again at whether their decision that the consent process is acceptable still stands.
(d) Cognitive effects- We recommend that advice from independent clinical experts in neurocognition and brain imaging should be sought to advise what degree of adverse BOLD fRI signal change between scans would necessitate withdrawal from the study. We would like to discuss this as a key safety assessment measure at 12 months.
Recommended Amendments to Individual Participant Withdrawal Criteria
7. We would like …

criteria at 12 months if this point is not already clear. See MHRA recommendation below. (b) Vaginal bleeding- There is a risk of flare-up effects in very young children who may not be able to report these developments; this is another reason why we suggest a minimum age limit should be introduced. In any event, for all participants we would like to discuss the provision of haematological monitoring, particularly if it persists beyond 2 weeks, as is sometimes seen when this agent is used in endometriosis treatment. Regular haematological monitoring in cases of bleeding beyond 2 weeks is suggested. Potential loss of fertility- It is widely understood that reduction in gametogenesis will very likely cause infertility in these young people. These are medically consequential effects for a future adult individual that may involve infertility treatment and significant medical interventions. In light of the long term fertility consequences, Gillick Competence for consent as per RCPCH and the Academy of Medical Sciences Guidelines (academy of medical royal colleges statement on gillick competency fina | 003.pdf) guidance on consent in children under 16 years of age should be sought. We suggest that this should be assessed and documented before consent is obtained using tools such as Gillick Competency checklist (Microsoft Word - Gillick Competence 2016 update.doc). Given the suggested changes, we would expect that an amendment would be submitted to HRA and the REC would want to look again at whether their decision that the consent process is acceptable still stands. (d) Cognitive effects- We recommend that advice from independent clinical experts in neurocognition and brain imaging should be sought to advise what degree of adverse BOLD fRI signal change between scans would necessitate withdrawal from the study. We would like to discuss this as a key safety assessment measure at 12 months. Recommended Amendments to Individual Participant Withdrawal Criteria 7. We would like …

β€’ Persistent Vaginal bleeding beyond 2 weeks could be considered as discontinuation criteria and to additionally require close follow-up with Haematological monitoring (FBC).
β€’ Cognitive effects - Withdrawal criteria if adverse functional MRI changes detected at any time point could be added. Advice to be sought by research team from experts in neuroimaging to clarify degree of adverse signal that would necessitate participant withdrawal at any scan but crucially at the 12 month point if an adverse signal of change from baseline is detected in order to prevent further harm to participants.
We suggest that a meeting should be set to discuss the above matters, to include the Sponsor team, the MHRA and the HRA.
As you will know, there is also potential legal action in relation to this trial which we are in the process of considering to determine whether, in our view, there are any further matters which impinge upon safety or efficacy that should also be considered alongside the issues set out above. If so, we will write to you as soon as possible.
Please let us know your availability for a meeting next week.
Yours sincerely

β€’ Persistent Vaginal bleeding beyond 2 weeks could be considered as discontinuation criteria and to additionally require close follow-up with Haematological monitoring (FBC). β€’ Cognitive effects - Withdrawal criteria if adverse functional MRI changes detected at any time point could be added. Advice to be sought by research team from experts in neuroimaging to clarify degree of adverse signal that would necessitate participant withdrawal at any scan but crucially at the 12 month point if an adverse signal of change from baseline is detected in order to prevent further harm to participants. We suggest that a meeting should be set to discuss the above matters, to include the Sponsor team, the MHRA and the HRA. As you will know, there is also potential legal action in relation to this trial which we are in the process of considering to determine whether, in our view, there are any further matters which impinge upon safety or efficacy that should also be considered alongside the issues set out above. If so, we will write to you as soon as possible. Please let us know your availability for a meeting next week. Yours sincerely

β€˜gender critical’ transphobes have brow-beaten the MHRA to raise the minimum age of the puberty blocker trial to 14 - making blockers pointless for many trans kids already a significant way through puberty! 😀

They’re trying to stop kids transitioning ANY way they can!

πŸ‘‰πŸ» www.gov.uk/government/n...

20.02.2026 20:15 β€” πŸ‘ 243    πŸ” 78    πŸ’¬ 18    πŸ“Œ 11

BREAKING. The β€œMedicines and Healthcare products Regulatory Agency” (packed with extremely transphobic staff) interferes with the puberty blockers trial and demand that somehow there must be a minimum age of 14.

This is fucking crazy.

20.02.2026 21:30 β€” πŸ‘ 95    πŸ” 27    πŸ’¬ 11    πŸ“Œ 4

Mood. πŸ˜’

18.02.2026 19:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Hilary Cass is such a useful idiot, she's claims trying to protect trans people, but you can't claim "waiting a bit longer" will help, you are carrying out the bidding of the terfs and bigots. You only bring us pain.

15.02.2026 07:30 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Hilary Cass here blaming trans people for our own discrimination and persecution.

We are only good when we totally assimilate and are not visibly trans, she says (lying) whilst making it harder for trans people to access medical care.

15.02.2026 07:22 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Preview
Stop Palantir taking over our public services! Our public services aren’t for a secretive profit-hungry US tech firm. Sign the petition to tell the Government to scrap all contracts with secretive US tech firm Palantir.

Palantir, a US spy-tech firm, has been given access to millions of NHS patient records.

Its founder has said the NHS should be 'ripped up'.

Join me in calling on the government to end the dangerous Palantir contract.

you.38degrees.org.uk/petitions/st...

13.02.2026 10:26 β€” πŸ‘ 4173    πŸ” 1903    πŸ’¬ 117    πŸ“Œ 87

Nationality/citizenship is such a bullshit concept.

I can jump on a plane and be on the other side of the planet in 12 hours and yet we have systems to stop me staying there too long because... what?

We're like the birds in my garden who have song battles over who gets to sit in the fucking tree

14.02.2026 16:55 β€” πŸ‘ 12    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Preview
Word Vomit I can hear people getting bored with me, but I can't stop

I have written a new Substack blog post, please read & subscribe for free, if you enjoy it. It's my motivation to start writing regularly again ✍🏻

I'm sure you will empathise with me, if you are also struggling with the shit going on in the world!

#blog #substack

open.substack.com/pub/serenast...

14.02.2026 16:57 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

One aspect of FWS that has not been widely remarked on is the bald assertion by UKSC (para 178) that trans women can’t breastfeed. This is, of course, false. But this falsehood was part of the reasoning behind the claim that the Equality Act obviously has a trans-exclusionary understanding of sex.

12.02.2026 10:08 β€” πŸ‘ 291    πŸ” 41    πŸ’¬ 3    πŸ“Œ 2