Ehud Isacoff Lab

Behavioral resilience via dynamic circuit firing homeostasis | PNAS www.pnas.org/doi/10.1073/...

During campus visit, U.S. representatives vow to fight freeze on federal research funding - Berkeley News East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu visited the Innovative Genomics Institute for a tour and briefing

East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu recently paid a visit to the University of California, Berkeley’s Innovative Genomics Institute to hear about the importance of NIH-funded basic research. news.berkeley.edu/2025/02/24/d...

Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site - Nature Structural & Molecular Biology Roy-Chowdhury et al. report structures of the human leak channel K2P13.1 that identify a hydrophilic pore restriction and a polyunsaturated-fatty-acid-binding site corresponding to a small-molecule ag...

Our THIK study of the THIK K2P is out showing a novel feature that affects function (flow restrictor) and a PUFA modulation site. Congratulations to my team. 🥳 See also work by @profkalium.bsky.social in the same issue of NSMB. A growing thicket of THIK structures 😃

www.nature.com/articles/s41...

Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns with @dirktrauner.bsky.social, Carmena Lab, and Lammel Lab.

Electrosome assembly: Structural insights from high voltage-activated calcium channel (CaV)–chaperone interactions Ion channels are multicomponent complexes (termed here as“electrosomes”) that conduct the bioelectrical signals required for life. It has been appreciated for decades that assembly is critical for pro...

Glad to share a new minireview with Zhou Chen summarizing our current thoughts on how cells make electrosomes (aka ion channels).

portlandpress.com/biochemsoctr...