Oriol Dols-Icardo

Genetic architecture of FTLD-TDP pathological subtypes Until recently, few genetic risk factors had been identified for the distinct pathological subtypes of frontotemporal lobar degeneration (FTLD) with T…

Thrilled to share our Spotlight on FTLD-TDP genetics in @cp-trendsneuro.bsky.social!
We discuss recent findings by Pottier et al., highlight overlapping genetic signals across TDP43 proteinopathies, and outline future directions @amsterdamumc.bsky.social

www.sciencedirect.com/science/arti...

We are grateful to the participants, ALS patients from
@NMDSantPau and cognitively unimpaired healthy controls from the SPIN @SantPauMemory cohorts, and to @FUNDELA for their invaluable support in funding this study‼️ #ALS #neuroinflammation #scRNAseq #Immunity #NK #NaturalKiller🧵7/7 👇
rdcu.be/d7iqy

Finally, our data also suggest that CD56bright NK cells influence neurodegeneration🧠

🎯We emphasize the importance of accounting for the diverse and specialized cell subpopulations to modulate the peripheral immune compartment in the treatment of neurodegenerative diseases🧵6/7

We also observed an increase in classical monocytes and CD56bright NK cells. Additionally, our data revealed 🧬gene expression alterations in other immune cell subtypes, such as CD8+ TEM cells, which upregulated genes linked to antigen presentation
(MHCII pathways) in ALS🧵5/7

☀️Our findings reveal the expansion of a cytotoxic and terminally differentiated NK cell subpopulation (named NK_2), along with significant alterations in gene expression and cell-cell communication patterns (HLA-E_CD94:NKG2C) specific to this mature NK subtype 🎯 in ALS 🧵4/7

of CD56dim NK cell diversity and their unique molecular hallmarks (gene expression and cell-cell communication patterns), as well as those of other immune cells. 🔎Our study leverages the high resolution and unbiased nature of scRNAseq to overcome these limitations 🧵3/7

Over the years, Natural Killer cells have been stratified into two major populations (CD56dim and CD56bright NK cells). Previous studies using flow cytometry implicated CD56dim NK cells in ALS. However, this method limited the precise identification 🧵2/7

Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis - Journal of Neuroinflammation Background Neuroinflammation plays a major role in amyotrophic lateral sclerosis (ALS), and cumulative evidence suggests that systemic inflammation and the infiltration of immune cells into the brain ...

📢Happy to share our latest research! Using single-cellRNAseq, we identified alterations in peripheral blood immune cells associated with ALS, highlighting the role of a specific NK subpopulation.🧵1/7
@SantPauMemory @irsantpau.bsky.social
👇
jneuroinflammation.biomedcentral.com/articles/10....