SFB 1453 NephGen

Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease Proteinuria causes ciliary elongation and actin cytoskeleton remodeling, revealing a key mechanism in kidney disease progression.

www.science.org/doi/10.1126/...

Pascal Schlosser and Matthias Wuttke, our
@sfb1453.bsky.social representation and speakers at this year's #kidneywk

The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture Nature Communications - The slit diaphragm is a key component of the glomerular filter. This study reveals that the slit diaphragm of Drosophila nephrocytes exhibits a fishnet architecture,...

Congratulations to @sfb1453.bsky.social PI Tobias Hermle and his team for their groundbreaking work on slit diaphragm architecture. Go check it out 👇

rdcu.be/eOzXF

Our study on the genetic determinants of kidney structure is available online in Kidney International as a pre-proof!

We used a CNN to derive kidney sub-volumes from MRIs and performed a GWAS to uncover their genetic determinants.

Thanks to all involved!
#CKD #Imaging #DeepLearning #GWAS

A massive shoutout to our @sfb1453.bsky.social colleague Nora Scherer from Anna Köttgen's group for receiving the @dgfn.bsky.social Rainer-Greger-Award for her outstanding dissertation! Congratulations and so well deserved!!! 🎉👏

We are delighted that our external advisory board member @ksusztak.bsky.social will be receiving this year’s Homer Smith Award at Kidney Week 2025. www.kidneynews.org/view/journal...
Congratulations Katalin, so well deserved! 👏👏💐

Brilliant presentations by our NephGen PIs Anna Köttgen, Ulla Schultheiss, Michael Köttgen and Sven Diederichs in the @sfb1453.bsky.social session at this year's Annual Meeting of the @dgfn.bsky.social
#Nephrologie #dgfn

Association of Serum Afamin Concentrations With Kidney Failure in Patients With CKD: Findings From the German CKD Cohort Study

bit.ly/4fWGYES #OpenAccess

#VisualAbstract

Super cool project! Maybe it's time for a NephGen comic? 🤔

Thank you to everyone who joined this years' EUKISS Summer School!!! 🎉🙏 It was an amazing meeting with lovely people, impressive science and hopefully many future collaborations and projects. 😍 See you next year in Aachen! #EUKISS25 #EUKISS

Huge congratulations to Dr. Magdalena Brislinger-Engelhardt for defending her PhD thesis today 👏👏👏🥳🥳🥳

Registration for this year’s EUKISS summer school in Freiburg, Germany, is now open! Join us in July for two days of discussions around the basis of kidney functions and their relevance for kidney disease!

Registration & program ➡️ www.eukiss.org

🧬 Looking forward to presenting at the #ESHG2025! Our GWAS & EWAS studies of 10,000+ individuals reveal how genetics & epigenetics regulate trace element metabolism. Visit our poster P18.057.D today at 4pm! Huge thanks to @sfb1453.bsky.social, @zkutalik.bsky.social, and all collaborators involved!

Congratulations to the CIBSS team for this outstanding achievement! So well deserved!!! 🎉👏👏

Congratulations!!! 🎉🎉

Wondering whether you should read the great kidney disease genetic scorecard paper by @hongbo919.bsky.social @ksusztak.bsky.social on 2.2Mio people?
Here 👇 rdcu.be/eejuB Matthias Wuttke at @sfb1453.bsky.social and I report some highlights for you (and recommend reading the original work) #nephgen

please re-post! we are looking for a PhD candidate:
www.uniklinik-freiburg.de/en/career/jo...

Today is #WorldKidneyDay! #MedSky #NephSky #StandUpforScience

#RareDiseaseDay #NephSky #MedSky

🚨2 fully funded postdoc positions for 6 years 🚨

Are you interested in gene regulation, cardiovascular diseases or aging? Join our team in beautiful Graz, Austria!

Postdoc in Bioinformatics 🖥️
tinyurl.com/3ufv767b

Postdoc in functional genomics and models (e.g. organoids) 🧪
tinyurl.com/4ucahvzn

Freiburger Forschende zeigen, wie seltene „Nonstop-Mutationen“ die Proteinbildung stören und die Entstehung von #Nierenkrebs fördern können. Erkenntnisse bieten Potenzial für bessere Diagnosen und Therapien.

Link zur Studie: t1p.de/ytfs3

#Medizin #Forschung

KDM5C and KDM5D mutations have different consequences in clear cell renal cell carcinoma cells - Communications Biology This study challenges the idea that KDM5D in male cells functions equivalently to the second KDM5C allele in female cells and implicates an interplay between KDM5C mutation and Y chromosome loss in cc...

This study challenges the idea that KDM5D in male cells functions equivalently to the second KDM5C allele in female cells, implicating an interplay between KDM5C mutation and Y chromosome loss in ccRCC development in men.
@sfb1453.bsky.social

www.nature.com/articles/s42...

🏷️ #ScienceAdvances @science.org #MedSky #NephSky

Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation Extending a protein at its end affects its stability, but also its translation efficiency and even selection of its start.

Congratulations to @sfb1453.bsky.social PIs Athina Ganner, Elke Neumann-Haefelin, Ian Frew, and Sven Diedierichs and their teams! 👏👏👏 Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation www.science.org/doi/10.1126/...

For NephGen every day is International #WomenInScienceDay 🔬👩‍🔬🎉

#WomenInScience #WomenInSTEM #February11

Join us for the fantastic annual @cshlnews.bsky.social #Xenopus cell & developmental Biology course.
Deadline for application is Jan 31st.

meetings.cshl.edu/courses.aspx...

And another brand new publication for @sfb1453.bsky.social: Published by Ian Frew and his group in collaboration with Anna Köttgen, Melanie Börries and Natalie Köhler in @kidneyint.bsky.social 🎉🎉🎉 #NephSky

www.kidney-international.org/article/S008...

Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits Nature Genetics - Gene-based rare variant aggregation study with the levels of 1,294 plasma and 1,396 urine metabolites from paired specimens of 4,737 participants reveals graded effects of rare,...

What a nice way to start the new year! Check out our article on the influence of rare #genetic variants on human #metabolism in the current issue of Nature Genetics
rdcu.be/d5ov1
Thanks to all collaborators and funders, @dfgpublic.bsky.social

Diese Frau leitet in Freiburg die bekannteste Gesundheitsstudie Deutschlands Anna Köttgen ist eine führende Expertin in der Genetischen Epidemiologie und Spezialistin für Nieren- und Stoffwechselerkrankungen. Sie leitet die Nako-Gesundheitsstudie in Freiburg und der Region und...

Our amazing @sfb1453.bsky.social speaker and leading PI of #nakogesundheitsstudie Freiburg Anna Köttgen gave an interview to the #BadischeZeitung 👏 👏
www.badische-zeitung.de/diese-frau-l...

While we're at it: We are looking for 2 postdocs. One with experience in dev. Biol (pref. With mouse experience) and one with bioinformatics / modeling / multi-omics experience. Exceptional PhD candidates will be also considered for the project via IMPRS @mpi-ie.bsky.social recruitment.