@yeastgenome.bsky.social
The Saccharomyces Genome Database (SGD) provides comprehensive biological information for the budding yeast Saccharomyces cerevisiae along with search and analysis tools to explore these data, enabling scientific discovery.
β Solving mitochondria isolation challenges: Traditional enzymatic methods compromise mitochondrial surface proteins in #Yeast; new glass bead mechanical approach preserves Atg32 integrity for quantitative #Mitophagy analysis
π¬ #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
πMapping mitochondrial proteins: APEX2 proximity labeling targets #Yeast mt compartments- intermembrane space & matrix- to identify their proteomes. Achieves ~75% coverage of known mitochondrial proteins with high confidence
𧬠#YeastResearch #SGD #Proteomics
www.yeastgenome.org/reference/S1...
β οΈ Why #Yeast avoids GPC toxicity: Git1 transporter has low affinity for glycerophosphocholine, preferring GPI; substrate specificity protects S. cerevisiae against GPC toxicity affecting other fungi with GPC-specific transporters
𧬠#YeastResearch #SGD #CellBiology
www.yeastgenome.org/reference/S1...
a headshot of David Botstein
We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD.
www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism
𧬠#Yeast model suggests new inherited neuropathy treatment:
Humanized yeast with nerve disease-associated HARS1 variant shows protein aggregation and stress response activation; GCN2 kinase inhibition rescues growth defect
π§ͺ #YeastResearch #SGD #RareDiseaseDay
www.yeastgenome.org/reference/S1...
𧬠Decoding RNA Pol I dynamics: #Yeast studies using biochemistry, biophysics & molecular dynamics reveal core factor uses 2-step promoter recognition- rapid encounterβconformational transition, followed by DNA bending & melting for activation
π§ͺ #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
𧬠Streamlined DNA extraction for #SyntheticBiology: New cost-effective EASY-C method efficiently isolates mini-chromosomes and plasmids from diverse #Yeast species including Sc2.0 & nonconventional yeasts, accelerating construct validation
π§ͺ #YeastResearch π¬ #SGD
www.yeastgenome.org/reference/S1...
π Engineering stop buttons: CRISPR KiSS system in #Yeast conditionally targets essential genes to inhibit growth.
Dual gRNA approach improves performance as researchers continue optimizing for cell factory applications
𧬠#YeastResearch π§ͺ #SGD #SyntheticBiology
www.yeastgenome.org/reference/S1...
π Ring of power: Seven exocysts form a flexible ring structure that pulls #Yeast secretory vesicles to the plasma membrane. Vesicles move stepwise from 45nm to 5nm to the PM in three metastable steps, revealing the mechanics of exocytosis
𧬠#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
𧬠Molecular network surprise: Compensating for polarity defects in #Yeast changes gene disruption tolerance genome-wide. Genes in same processes show coordinated tolerance changes; compensation rewires modules rather than individual genes
π§ͺ #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
πDo #Yeast celebrate #ValentinesDay? Study of nearly 100 natural strains reveals some yeast combinations prefer each other, while others avoid mating. Carbon source matters: glucose favors parental fitness, glycerol favors genetic distance
𧬠#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
YRF1-1/YDR545W against S288C ORFs- try it now at https://www.alliancegenome.org/blast/SGD/R64-5-1m https://doi.org/10.1093/molbev/msz185
𧬠#SGD evolution continues: Our #BLAST service has migrated to the @alliancegenome.bsky.social website, maintaining the functionality & comprehensive SGD datasets #Yeast researchers depend on while adding cross-species exploration & faster search results
π§ͺ #YeastResearch
π bit.ly/newBLAST
𧬠#Yeast Dsk2 uses its STI1 domain to interact with transient helices, driving phase separation and proteasome condensate formation under stress. This reveals new details about how cells organize protein degradation machinery
π§ͺ #YeastResearch #SGD #ProteinQuality
www.yeastgenome.org/reference/S1...
𧬠Engineering stress-resistant #Yeast: Overexpressing PIR3 & SPI1 helps yeast tolerate high-concentration molasses stress from potassium/calcium ions. Modified strains showed significantly higher ethanol production than wt
π§ͺ #YeastResearch #SGD #Biotechnology
www.yeastgenome.org/reference/S1...
π» Networks reveal hidden connections: #Yeast genetic & protein interaction networks share unexpected topological similarities, suggesting genetic epistasis & physical protein binding follow similar organizational rules
π§ͺ #YeastResearch #SGD #ComputationalBiology
www.yeastgenome.org/reference/S1...
π¬ How does #Yeast optimize protein secretion? SEC72 deletion reshapes cellular functions including iron homeostasis and cell wall assembly, boosting secretion of proteins with strongly hydrophobic signal peptides
π§ͺ #YeastResearch #SGD #CellBiology #Biotechnology
www.yeastgenome.org/reference/S1...
π©Ί From #Yeast to human disease:
Reseach shows metabolic pathway disruption causes amino acids to self-assemble into toxic amyloid structures, providing new insights into inherited metabolic disorders and potential treatments
π¬ #YeastResearch #SGD #DiseaseModeling
www.yeastgenome.org/reference/S1...
π What makes partnerships last?
#Yeast communities exchanging nutrients reveal asymmetric fitness effects determine which species survive. Lysine-dependent strains outlasted adenine-dependent ones
β resource essentiality shapes #evolution
𧬠#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
π¬ How do antifungal drugs work?
New cryo-EM structures reveal how a triterpenoid drug binds #Yeast Ξ²-1,3-glucan synthases Fks1 & Fks2, reorganizing lipids and stabilizing the enzyme to block fungal cell wall synthesis
π§ͺ #YeastResearch #SGD #StructuralBiology
www.yeastgenome.org/reference/S1...
𧬠#Yeast condensin does more than organize chromosomes.
New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins.
#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
π§¬What happens when #Yeast lose their peroxisomes?
New #metabolomics study reveals they affect more than just fatty acid breakdown, but also influence lipid synthesis & polyamine homeostasis-expanding our view of peroxisome function
#YeastResearch #SGD #OpenScience
www.yeastgenome.org/reference/S1...
𧬠Overcoming glucose preference: Newly evolved #Yeast strain efficiently co-ferments glucose and xylose from plant biomass, producing ethanol with better redox balance and reduced xylitol formation
π§ͺ #YeastResearch #SGD #SustainableFuels
www.yeastgenome.org/reference/S1...
β‘ Unconventional zinc finger binding! Newly solved structure shows #Yeast Fzf1 transcription factor uses non-canonical DNA binding strategy with its 5 zinc fingers; unusual binding pattern controls key stress response genes like SSU1 and YHB1
𧬠#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
𧬠Meet Sni445, a newly discovered #Yeast ribosome assembly factor! Ynl050c/Sni445 recruits specialized snoRNPs (snR4 & snR45) that guide precise rRNA acetylation during ribosome synthesis. Another piece of the puzzle solved!
π§ͺ #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
Join SGD at #Yeast26 for cutting-edge #yeast research, networking opportunities, engaging talks, poster sessions, and workshops, for everyone from early career scientists to experienced researchers! Abstract submission by Mar5, early registration ends Apr16. See you there! @genetics-gsa.bsky.social
29.01.2026 16:51 β π 8 π 5 π¬ 0 π 1
𧬠20 years ago, discovery of the EGO complex in #Yeast revolutionized understanding of nutrient signaling. New review explores how Rag GTPases link amino acids to TORC1 growth control, establishing blueprint for cross-species nutrient sensing
π¬ #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
π¬ Study uncovers critical balance in #yeast mRNA export:
Elevated Mex67-Mtr2 exporter levels in nuclear ribonucleoprotein particles impairs export efficiency, showing precise, not maximal, levels are needed for proper cellular function
𧬠#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
π¬ New #yeast paper! Eukaryotic ribosome assembly follows unique pathway distinct from bacteria: Rlp7 depletion experiments show foot structure factors are essential for proper rRNA domain compaction and r-protein incorporation
𧬠#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
π₯ Knocking out MNN11 glycosyltransferase in #yeast = β¬οΈ taxadiene synthase expression & boosts taxadiene yield. New #YeastResearch shows endogenous glycosylation modifications can limit heterologous protein function in #pharmaceutical precursor production.
𧬠#SGD
www.yeastgenome.org/reference/S1...
𧬠New #YeastResearch shows Tif35 (eIF3g) recognizes specific RNA sequences - GUCG boxes - and boosts production of heat shock proteins during stress, revealing how #yeast cells selectively increase translation of protective genes when needed #SGD
www.yeastgenome.org/reference/S1...