Saccharomyces Genome Database

🔬 Solving mitophagy mysteries: Study identifies Mfi2 as second #Yeasr mitofissin, working with Atg44 to fragment mitochondria during autophagy; reveals how mitochondria are cut when traditional Dnm1 machinery is dispensable

🧪 #YeastResearch #SGD #CellBiology
www.yeastgenome.org/reference/S1...

Symposium honoring Distinguished Professor Emeritus Jeremy Thorner entitled “Saccharomyces cerevisiae: The Very Model of a Modern Model Organism”. Monday March 23, 2026 from 9a-6p in Berkeley #yeast #modelOrganism Registration still open! mcb.berkeley.edu/cdp-symposium

🧬 Proteins "kick & scream" to function: Review explores dynamic allostery, where rapid side-chain motions (not conformational changes) drive allosteric regulation. #Yeast Sgt2 chaperone is key example of how disordered tails control dynamics
🧪 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

🍻 Great news!🥂
Abstract deadline for #Yeast26 extended to Thursday, March 12 @ 8:00 PM EST. Perfect opportunity to present your research, get feedback, and form new collaborations at #Asilomar this summer. Your work doesn't need to be presentation-ready - submit now!
🧬 #YeastGenetics #YGM2026 🧪

🍺 Fixing brewing #Yeast! 🧬 Experimental evolution corrects mother-daughter separation defects in ale strain over 200 generations:
✅ fewer large clusters
✅ reduced foam accumulation during fermentation
🧪 #YeastResearch #SGD #MoreGoodPours @micropub7n.bsky.social
www.yeastgenome.org/reference/S1...

#Yeast #Genetics Meeting 2026 is in June - Abstract deadline is TODAY! Submit your abstract, attend the meeting this summer in Pacific Grove, CA at #Asilomar Conference Grounds, a 107-acre protected coastal state park located on the Monterey Peninsula. #Yeast26 #YGM2026 genetics-gsa.org/yeast-2026/

❓ Solving mitochondria isolation challenges: Traditional enzymatic methods compromise mitochondrial surface proteins in #Yeast; new glass bead mechanical approach preserves Atg32 integrity for quantitative #Mitophagy analysis

🔬 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

📍Mapping mitochondrial proteins: APEX2 proximity labeling targets #Yeast mt compartments- intermembrane space & matrix- to identify their proteomes. Achieves ~75% coverage of known mitochondrial proteins with high confidence
🧬 #YeastResearch #SGD #Proteomics
www.yeastgenome.org/reference/S1...

☠️ Why #Yeast avoids GPC toxicity: Git1 transporter has low affinity for glycerophosphocholine, preferring GPI; substrate specificity protects S. cerevisiae against GPC toxicity affecting other fungi with GPC-specific transporters
🧬 #YeastResearch #SGD #CellBiology
www.yeastgenome.org/reference/S1...

a headshot of David Botstein

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD.
www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

🧬 #Yeast model suggests new inherited neuropathy treatment:
Humanized yeast with nerve disease-associated HARS1 variant shows protein aggregation and stress response activation; GCN2 kinase inhibition rescues growth defect
🧪 #YeastResearch #SGD #RareDiseaseDay
www.yeastgenome.org/reference/S1...

🧬 Decoding RNA Pol I dynamics: #Yeast studies using biochemistry, biophysics & molecular dynamics reveal core factor uses 2-step promoter recognition- rapid encounter⇒conformational transition, followed by DNA bending & melting for activation
🧪 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

🧬 Streamlined DNA extraction for #SyntheticBiology: New cost-effective EASY-C method efficiently isolates mini-chromosomes and plasmids from diverse #Yeast species including Sc2.0 & nonconventional yeasts, accelerating construct validation
🧪 #YeastResearch 🔬 #SGD
www.yeastgenome.org/reference/S1...

🛑 Engineering stop buttons: CRISPR KiSS system in #Yeast conditionally targets essential genes to inhibit growth.
Dual gRNA approach improves performance as researchers continue optimizing for cell factory applications

🧬 #YeastResearch 🧪 #SGD #SyntheticBiology
www.yeastgenome.org/reference/S1...

🌋 Ring of power: Seven exocysts form a flexible ring structure that pulls #Yeast secretory vesicles to the plasma membrane. Vesicles move stepwise from 45nm to 5nm to the PM in three metastable steps, revealing the mechanics of exocytosis

🧬 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

🧬 Molecular network surprise: Compensating for polarity defects in #Yeast changes gene disruption tolerance genome-wide. Genes in same processes show coordinated tolerance changes; compensation rewires modules rather than individual genes
🧪 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

💕Do #Yeast celebrate #ValentinesDay? Study of nearly 100 natural strains reveals some yeast combinations prefer each other, while others avoid mating. Carbon source matters: glucose favors parental fitness, glycerol favors genetic distance

🧬 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

YRF1-1/YDR545W against S288C ORFs- try it now at https://www.alliancegenome.org/blast/SGD/R64-5-1m https://doi.org/10.1093/molbev/msz185

🧬 #SGD evolution continues: Our #BLAST service has migrated to the @alliancegenome.bsky.social website, maintaining the functionality & comprehensive SGD datasets #Yeast researchers depend on while adding cross-species exploration & faster search results
🧪 #YeastResearch
🔗 bit.ly/newBLAST

🧬 #Yeast Dsk2 uses its STI1 domain to interact with transient helices, driving phase separation and proteasome condensate formation under stress. This reveals new details about how cells organize protein degradation machinery
🧪 #YeastResearch #SGD #ProteinQuality
www.yeastgenome.org/reference/S1...

🧬 Engineering stress-resistant #Yeast: Overexpressing PIR3 & SPI1 helps yeast tolerate high-concentration molasses stress from potassium/calcium ions. Modified strains showed significantly higher ethanol production than wt
🧪 #YeastResearch #SGD #Biotechnology
www.yeastgenome.org/reference/S1...

💻 Networks reveal hidden connections: #Yeast genetic & protein interaction networks share unexpected topological similarities, suggesting genetic epistasis & physical protein binding follow similar organizational rules
🧪 #YeastResearch #SGD #ComputationalBiology
www.yeastgenome.org/reference/S1...

🔬 How does #Yeast optimize protein secretion? SEC72 deletion reshapes cellular functions including iron homeostasis and cell wall assembly, boosting secretion of proteins with strongly hydrophobic signal peptides

🧪 #YeastResearch #SGD #CellBiology #Biotechnology
www.yeastgenome.org/reference/S1...

🩺 From #Yeast to human disease:
Reseach shows metabolic pathway disruption causes amino acids to self-assemble into toxic amyloid structures, providing new insights into inherited metabolic disorders and potential treatments

🔬 #YeastResearch #SGD #DiseaseModeling
www.yeastgenome.org/reference/S1...

💕 What makes partnerships last?
#Yeast communities exchanging nutrients reveal asymmetric fitness effects determine which species survive. Lysine-dependent strains outlasted adenine-dependent ones
⇒ resource essentiality shapes #evolution

🧬 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

🔬 How do antifungal drugs work?
New cryo-EM structures reveal how a triterpenoid drug binds #Yeast β-1,3-glucan synthases Fks1 & Fks2, reorganizing lipids and stabilizing the enzyme to block fungal cell wall synthesis

🧪 #YeastResearch #SGD #StructuralBiology
www.yeastgenome.org/reference/S1...

🧬 #Yeast condensin does more than organize chromosomes.
New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins.
#YeastResearch #SGD
www.yeastgenome.org/reference/S1...

🧬What happens when #Yeast lose their peroxisomes?
New #metabolomics study reveals they affect more than just fatty acid breakdown, but also influence lipid synthesis & polyamine homeostasis-expanding our view of peroxisome function
#YeastResearch #SGD #OpenScience
www.yeastgenome.org/reference/S1...

🧬 Overcoming glucose preference: Newly evolved #Yeast strain efficiently co-ferments glucose and xylose from plant biomass, producing ethanol with better redox balance and reduced xylitol formation
🧪 #YeastResearch #SGD #SustainableFuels

www.yeastgenome.org/reference/S1...

⚡ Unconventional zinc finger binding! Newly solved structure shows #Yeast Fzf1 transcription factor uses non-canonical DNA binding strategy with its 5 zinc fingers; unusual binding pattern controls key stress response genes like SSU1 and YHB1
🧬 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

🧬 Meet Sni445, a newly discovered #Yeast ribosome assembly factor! Ynl050c/Sni445 recruits specialized snoRNPs (snR4 & snR45) that guide precise rRNA acetylation during ribosome synthesis. Another piece of the puzzle solved!

🧪 #YeastResearch #SGD

www.yeastgenome.org/reference/S1...