Kevin Messacar MD PhD

Images in Clinical Medicine Subacute Sclerosing Panencephalitis after Measles Infection Panels A and B: MRI of the head showing edema and restricted diffusion in the frontal lobes that involved the cortical ribbon and white matter and extended into the corpus callosum.

A 7-year-old boy was brought to a hospital with a 3-month history of cognitive deterioration and seizures. He had contracted measles at 7 months of age while living in an area where the infection is endemic. Read the full case details: nej.md/4qY4Ihk

#MedSky #NeuroSky #IDSky

As cases of a rare, deadly infection rise, doctors worry fewer teens will get vaccinated Under Robert F. Kennedy Jr.’s guidance, the CDC no longer recommends routine vaccination to protect against meningococcal disease.

Deaths from bacterial meningitis will rise if fewer teens are vaccinated, doctors warn. After the CDC recommended that all adolescents get vaccinated against meningococcal disease in 2005, cases of the potentially deadly illness plummeted in the U.S. by 90%.
www.nbcnews.com/health/healt...

Interesting new paper on value of serological surveillance for reconstructing epidemics: www.thelancet.com/journals/lan...

And accompanying comment by @scauchemez.bsky.social: www.thelancet.com/journals/lan...

As cases of a rare, deadly infection rise, doctors worry fewer teens will get vaccinated Under Robert F. Kennedy Jr.’s guidance, the CDC no longer recommends routine vaccination to protect against meningococcal disease.

It’s typical for different countries to have different vaccine schedules, experts told me for this explainer on why the CDC, until Monday, universally recommend led the MenACWY vaccine. www.nbcnews.com/health/healt...

As cases of a rare, deadly infection rise, doctors worry fewer teens will get vaccinated Under Robert F. Kennedy Jr.’s guidance, the CDC no longer recommends routine vaccination to protect against meningococcal disease.

“Bacterial meningitis can progress quickly, causing the brain to swell and limbs to develop gangrene and sepsis, and can kill within 24 hours… “It’s even more important now that we get meningococcal vaccines out to people given that we are seeing a spike in this Y strain,” Messacar said.”

Learn about our Clinical Translational Research Centers (CTRCs) Discover how the CCTSI’s Clinical Translational Research Centers (CTRCs) support high-quality clinical research across Colorado. From specialized research nursing and exercise facilities to core lab…

Our Clinical Translational Research Centers (CTRCs) provide dedicated, research-only space and resources like core lab and nutrition services to support your #clinical research studies!

@kmess44.bsky.social, @cupediatrics.bsky.social, @drhigginsmd.bsky.social, @cudeptofmedicine.bsky.social

1/ 🚀 Exciting news: we’ve just released the first Nextclade dataset for Enterovirus D68 (EV-D68), developed in collaboration with the European Non-Polio Enterovirus Network (ENPEN).

👉🏻 Check out the dataset on Nextclade! clades.nextstrain.org?dataset-name...

#EVD68 #Enterovirus #OpenData

Depends on presentation, there is significant overlap

Now is the time to integrate serology into routine infectious disease surveillance Syndromic and virological surveillance are essential for epidemic intelligence, which can be defined as the capacity to effectively identify, monitor, understand, and forecast infectious disease outbr...

Accompanying commentary:
#IDSky

www.thelancet.com/journals/lan...

Early registration ends October 1 for our Pediatric Infectious Disease Fall Update
🗓️Wed November 5 in person & online
✏️MOC & CME
🦠Updates on vaccines, measles, COVID, influenza, sinusitis, pneumonia and skin & soft tissue infections
ce.childrenscolorado.org/content/27th...
@cupediatrics.bsky.social

Join our 1-day Infectious Diseases Conference!
When: Nov 5
Where: Virtual or in-person at Children's Hospital Colorado
What: Updates on ACIP, vaccines & vaccine hesitancy; mgmt of measles, UTI, SSTI, CAP, sinusitis, tick illnesses, and more!
Register now: ce.childrenscolorado.org/content/26th...

Dr. Kevin Messacar stands in front of a blue backdrop.

Why did viruses like flu and RSV reemerge after the #COVID19 pandemic? A recent study from our #InfectiousDisease experts led by principal investigator @kmess44.bsky.social reveals insights about viruses, our immune system and how to prepare for the future: prn.to/4lztth8

Now is the time to integrate serology into routine infectious disease surveillance Syndromic and virological surveillance are essential for epidemic intelligence, which can be defined as the capacity to effectively identify, monitor, understand, and forecast infectious disease outbr...

New comment

Now is the time to integrate serology into routine infectious disease surveillance

www.thelancet.com/journals/lan...

Thanks Jess! I have no idea what I am doing on here... even less so than Twitter. I'd love to follow more #IDSky so please follow/reach out if you are interested in #pedsID #diagnosticstewardship #enterovirus #EVD68 #EVA71 #acuteflaccidmyelitis #encephalitis #meningitis #pandemicpreparedness

Thanks Jess! I have no idea what I am doing on here... even less so than Twitter. I'd love to follow more #IDSky so please follow/reach out if you are interested in #pedsID #diagnosticstewardship #enterovirus #EVD68 #EVA71 #acuteflaccidmyelitis #encephalitis #meningitis #pandemicpreparedness

Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022–23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study In this study, we captured immunological evidence of endemic virus re-emergence in children following lifting of pandemic NPIs, which revealed high rates of exposure to endemic respiratory pathogens i...

This study confirms what we all saw - a surge in endemic respiratory viruses after COVID precautions lifted, and demonstrates the utility of immunoepidemiological surveillance…

#IDSky

www.thelancet.com/journals/lan...

Authors noted:
🟢 ⬆️Ab titres supports the hypothesis of ⬆️susceptible population of young children building up during the pandemic infection pause
🟢 subsequent ⬆️Ab in population-level immunity after
NPIs lifted
🟢⬆️Ab likely reflects ⬆️viral circulation after NPIs lifted➡️virus re-emergence

Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022–23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study.
h/t to @cidrap.bsky.social www.thelancet.com/journals/lan...

Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022–23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study In this study, we captured immunological evidence of endemic virus re-emergence in children following lifting of pandemic NPIs, which revealed high rates of exposure to endemic respiratory pathogens in a large group of seronegative, predominantly younger, children. This study demonstrates the feasibility and utility of immunoepidemiological surveillance to enable more precise and accurate modelling of pathogen circulation dynamics to predict and prepare for future waves of disease.

Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022–23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study

Yes the infection pause or immune gap is measurable.

www.thelancet.com/jo...
1/10

Immunologic study shows rebound of other viruses after COVID measures lifted

The authors showed how a relatively small serosurveillance scheme could complement traditional surveillance, enhancing epidemic understanding and forecast modeling.

www.cidrap.umn.edu/c...

Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022–23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study In this study, we captured immunological evidence of endemic virus re-emergence in children following lifting of pandemic NPIs, which revealed high rates of exposure to endemic respiratory pathogens i...

New Research:

Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022–23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study

www.thelancet.com/journals/lan...