Silvia Remeseiro Lab

What Epigenetics Teaches Us About Neuron–Glioma Interactions Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense ....

Read here our 'Ideas & Speculations' now out @wiley.com #BioEssays on how #neuron–glioma #interactions begin to be
decoded through the #epigenetic lens.
#GBM #glioma #CancerNeuroscience

onlinelibrary.wiley.com/doi/10.1002/...

Now out @genomeresearch.bsky.social this fantastic work in collaboration with Claudio Cantù's lab.

About how #Wnt signalling activation induces #CTCF binding and formation of new #chromatin #loops at #CREs of target genes.

genome.cshlp.org/content/earl...

Stronger Berzelius ready for the research of the future The latest upgrading of the supercomputer Berzelius at LiU has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as mater...

The latest upgrading of the #supercomputer Berzelius @liu.se has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as materials science, bioinformatics and machine learning #research #science
tinyurl.com/ydduwzc7

Starkare Berzelius är redo för framtidens forskning Nu är den senaste uppgraderingen av superdatorn Berzelius vid LiU klar. Med en fördubblad kapacitet kan forskare i hela Sverige ta sig an samtidens och framtidens utmaningar inom bland annat materialv...

Nu är den senaste uppgraderingen av superdatorn Berzelius @liu.se klar. Med en fördubblad kapacitet kan forskare i hela Sverige ta sig an samtidens och framtidens utmaningar inom bland annat materialvetenskap, bioinformatik och maskininlärning #forskning #vetenskap
tinyurl.com/nns7pks6

Welcome! You are invited to join a webinar: The 3D Regulatory Genome: Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches. After registering, you will rec... Join our guest speaker, Dr. Alvaro Rada-Iglesias, in this exciting seminar on the 3D Regulatory Genome, sponsored by Enhanced Genomics.

Really looking forward to @radaiglesiaslab.bsky.social's talk on "Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches" in @enhancedgenomics.bsky.social's seminar series.

📅 June 5th 2025 tomorrow
⏰ 4pm GMT

Please join us:
us02web.zoom.us/webinar/regi...

High-grade gliomas integrate into neural circuits in the human brain affecting cognition, language and decreasing survival. Fascinating field!
See you at #PALS2025

Are you a US-based researcher who want to return to #Sweden 🇸🇪 to establish your #research here?

This is your shot to make it happen 👇
strategiska.se/en/press-rel...

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

Work funded by @kawresearch.bsky.social @vetenskapsradet.bsky.social #Cancerfonden #StratNeuro #Kempestiftelsen #CancerforskningsfondenNorrland

📍 @umeauniversitet.bsky.social #WCMM_Umeå

Collab with #CemalErdem @kirkebylab.bsky.social @hornblad-lab.bsky.social

With these studies we have showed that #epigenetic regulators of the #neuron-to-glioma axis can serve as actionable #targets in #GB.

Viewing neuron-glioma interactions through an epigenetic lens helped us understand how glioma cells exploit neural signals to fuel their growth.

#ARX, #GSX2 and members of the #DLX family were identified as key #TFs regulating #GABAergic related networks in #GB.

AMPAR antagonist NBQX reduces GB cell proliferation in co-culture with glutamatergic neurons, as expected. But the GABAAR antagonist picrotoxin doesn’t affect GB growth in the setting with GABAergic interneurons. This suggests #GABA signalling drives #GB growth through non-synaptic mechanisms.

#GABAergic neuron-to-glioma synapses were recently found in #DMG/#DIPG, but not #GB @michellemonje.bsky.social @tarabarron.bsky.social

Yet our ML-based analysis flagged #GABA signalling as key in #GB. Notably, we showed that #GABAergic neurons promote #GB cell proliferation in co-culture assays.

#glutamatergic neuron-to-glioma synapses were found in #glioblastoma — key findings from @winklerlab.bsky.social @michellemonje.bsky.social
We showed the SMAD3-PITX1 GRN drives this crosstalk. SMAD3 inhibition + neural activity boosts #GB growth in co-culture with glutamatergic neurons and in vivo.

Among the new #GRNs that we identified, #GABA signalling emerges as a previously unrecognised player in #glioblastoma.

Now we applied #MOBILE, a #ML based method, to integrate #multiomics data from #GB and uncovered new #GRNs and #TFs relevant for #glioblastoma pathogenesis.

📝 doi.org/10.1101/2025...

Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication - Nature Communications The integration of transcriptomics and epigenomics data helps to better understand the regulatory and topological changes in glioblastoma subtypes. Here, the authors map the promoter-enhancer interact...

Over a year ago in @natcomms.nature.com we showed how rewiring of #enhancer landscape & #3Dgenome underlies #neuron-to-glioma synaptic communication in #GB. SMAD3 & PITX1 emerged as key #TF and targeting them alters tumour growth.
doi.org/10.1038/s414...

📣 New pre-print from the lab:
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM

📝 Read the #BioRxiv here:
doi.org/10.1101/2025...

Doctoral Student in Tumor Biology Description of the workplace The research group conducts experimental research on brain tumors and is led by Associate Professor Alexander Pietras. The group consists of a bioinformatician, two postdo

🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...

Spetses Summer School on Functional Genomics of Metabolic Diseases

functionalgenomics2025.febsevents.org

Link to register here 👇
www.kva.se/evenemang/br...

Just a few spots left for this exciting symposium on brain tumor plasticity—grab yours (free of charge!) before they're gone! 🚨

Generously supported by the Academy and the Ragnar Söderberg Foundation.

Organizing committee: @pietraslab.bsky.social #MargaretaWilhelm #FredrikSwartling & @remeseiro-lab.bsky.social

Invited speakers: @winklerlab.bsky.social #MarieCarlen @gocastelobranco.bsky.social @leilaakkari.bsky.social #AnnaDimberg #MattiasBelting #RameenBeroukhim #SvenNelander

Brain Tumor Plasticity A growing body of evidence emphasizes the presence of significant intra-tumoral phenotypic diversity and plasticity within brain tumors. Inherent plasticity introduces an additional layer of intricacy...

🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social

Few spots available. Register here: ui.ungpd.com/Events/ed387...

Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

Can other PIs vote from home? 🤪
I wanna know about the outcome!

😂 I know! Casi nos hemos cruzado! Yo estoy ahora de camino a Santander. Disfruta de Estocolmo!

Epichrom 2025 !

After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.

Registration is free of charge
www.bartosovic-lab.com/epichrom

DNA-guided transcription factor interactions extend human gene regulatory code - Nature A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...