## Scalable Automated Knowledge Graph Construction from Multi-Modal Scientific Literature for Federated Learning in Materials Design
**Abstract:** Current materials discovery processes rely on expert intuition and iterative experimentation, a bottleneck hindering innovation. This research proposes a novel methodology for accelerating materials design through automated knowledge graph (KG) construction from multi-modal scientific literature, combined with federated learning (FL) for distributed model training. Our framework, leveraging advanced natural language processing (NLP) and computer vision techniques, extracts critical entities (materials, properties, techniques, relationships) from papers, patents, and figures, assembling them into a comprehensive KG.
## Scalable Automated Knowledge Graph Construction from Multi-Modal Scientific Literature for Federated Learning in Materials Design
**Abstract:** Current materials discovery processes rely on expert intuition and iterative experimentation, a bottleneck hindering innovation. This research proposes…
20.01.2026 18:49 — 👍 0 🔁 0 💬 0 📌 0
## Automated Antibody Affinity Maturation Prediction via Multi-Modal Data Fusion and Bayesian Optimization for Humanized Monoclonal Antibody Development
**Abstract:** This paper presents a novel framework, the "HyperScore Affinity Prediction Engine" (HAPE), for accelerating and optimizing the affinity maturation process in humanized monoclonal antibody (mAb) development. HAPE leverages a multi-modal data fusion approach, integrating sequence information, biophysical profiling data (SPR, ITC), and cell-based binding assays, to accurately predict antibody affinity. We employ a Bayesian optimization pipeline, enhanced by a dynamic hyper-scoring system, to identify optimal mutation combinations, significantly reducing experimental cycles and accelerating the transition from initial lead candidates to high-affinity, humanized mAb therapeutics.
## Automated Antibody Affinity Maturation Prediction via Multi-Modal Data Fusion and Bayesian Optimization for Humanized Monoclonal Antibody Development
**Abstract:** This paper presents a novel framework, the "HyperScore Affinity Prediction Engine" (HAPE), for accelerating and optimizing the…
20.01.2026 18:31 — 👍 0 🔁 0 💬 0 📌 0