Javier Alegre-Cortés

Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish Most fish are inherently unstable and must swim to stabilize posture. How diurnal fish reduce activity at night while maintaining postural control remains unclear. We defined distinct locomotor strate...

Like most animals, fish move less at night. Underwater, stable posture requires movement. Find out how fish don't fall down at night in: Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish from @yunluzhu.bsky.social
doi.org/10.1101/2025...

I will be in Bordeaux presenting my ongoing work in the @karalis-lab.bsky.social at the #NeuralNet2025 meeting.

If anyone is attending, come say hi!

Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model The human brain displays substantial regional variability in molecular, anatomical, and physiological organization. Yet, how this heterogeneity shapes large-scale neuronal dynamics remains poorly unde...

I'm really happy to share our latest work:

“Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model”

www.biorxiv.org/content/10.1...

Congrats!
Happy to see this story out, looking forward to reading it!

Sensory expectations shape neural population dynamics in motor circuits Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...

Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...

Falling asleep follows a predictable bifurcation dynamic - Nature Neuroscience Li et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s nonlinear wake-to-sleep transiti...

My co-authors have yet to move to Bluesky, so I'm pleased to announce our latest work has just been published in @nature.com Neuroscience. Amazing work led by Junheng Li, revealing that falling asleep follows a predictable bifurcation pattern #neuroskyence #sleep
www.nature.com/articles/s41...

Un estudio del Instituto de Neurociencias CSIC-UMH revela cómo el cerebro organiza y dirige su actividad más lenta | Consejo Superior de Investigaciones Científicas El cerebro nunca descansa, incluso durante el sueño profundo o bajo anestesia mantiene una actividad eléctrica rítmica conocida como oscilaciones lentas.

📰 "Un modelo computacional avanzado basado en datos reales sobre la anatomía y la fisiología del cerebro de mamíferos permite simular con realismo cómo se comportan las redes neuronales al conectarse".

🔬 @alegrecortes.bsky.social
🏛️ @neuroalc.bsky.social
🔗

Silent hills vibes at Izu peninsula

Izumo

Holidays!

Here we go again

🔥A new study led by @reiglab.bsky.social and @alegrecortes.bsky.social is now published on @cp-iscience.bsky.social 🙌
Researchers reveal how the brain organizes and directs its slowest activity: slow waves 🧠
More info 👇
in.umh-csic.es/en/articulos...

Stimulus-Dependent Dopamine Dynamics from LocusCoeruleus Axons https://www.biorxiv.org/content/10.1101/2025.09.15.676390v1

Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...

Finding correlates of the same signal in different brain areas is not evidence against specialisation, it is evidence for interconnection.

When I flush my toilet, the level in the tank and the flow rate in the supply pipe become perfectly correlated. Yet these toilet areas have distinct functions.

Scientists in training should be taught the creative scientific process, to gain confidence in their self-efficacy for research and identity as a scientist, & also for greater work satisfaction and a better chance of remaining in science long-term. Join our community at www.night-science.org

I wrote a Comment on neurotheory, and now you can read it!

Some thoughts on where neurotheory has and has not taken root within the neuroscience community, how it has shaped those subfields, and where we theorists might look next for fresh adventures.

www.nature.com/articles/s41...

We should always take seriously where computational descriptions fail, as it tells us something about where the current boundaries of what we can describe in language lie

1. The philosophy of science sometimes gets an unearned reputation as a purely academic exercise that offers little by way of concrete tools for advancing research.

This is wrong.

And today, as we grapple with how AI is changing the nature of scientific activity, it's desperately wrong.

If you want to join us for a short stay and learn with us, that's a good opportunity. If you are interested, get in touch!

Lakatos on Popper isn't half bad

Precision Neurotechnologies Backed by £69m, this programme aims to unlock new methods to interface with the human brain at the cellular level, with unprecedented precision.

🚨 Upcoming postdoc openings 🚨

We will soon be hiring postdocs to work on neural data analysis & modelling in the context of a recently awarded ARIA grant aimed at "precision control" of neural population dynamics (w. collabs. across the UK)

Reach out if interested!

www.aria.org.uk/opportunity-...

🚨New paper🚨

Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.

Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW

We are looking for a Postdoc (up to 5 years) who wants to study neural mechanisms of spatial memory in honeybees.

This includes tetrode recordings in behaving honeybees.

Application Deadline is 1st of October 2025.

More details:
www.biozentrum.uni-wuerzburg.de/en/services/...

A neural manifold view of the brain - Nature Neuroscience Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!

🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW

I'm very happy to see my first modelling work being published!
If you want to know more, take a look at the thread I wrote for the preprint version of the paper:
bsky.app/profile/aleg...

Global and local nature of cortical slow waves Explaining the macroscopic activity of a neuronal population from its microscopic properties poses a great challenge, not just because of the many local agents that play a role, but due to the impact ...

I'm excited to share my latest publication! 🚨
Global and local nature of cortical slow waves:
www.cell.com/iscience/ful...

In brief, we explored in silico how cortical slow waves are shaped by both external inputs and intrinsic properties of neuronal populations.

Brain Surfaces of 70 primate species

1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Finally published:
“Explosive neural networks via higher-order interactions in curved statistical manifolds”
nature.com/articles/s4146…

Enhancing the capabilities of recurrent neural networks by deforming their geometry!