George Caputa

A foundation model of transcription across human cell types - Nature A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

For single cell foundation model fans, Raul Rabadan & colleagues just published GET in @nature.com, which trained on chromatin accessibility data to predict transcription factor interactions/motifs, cis-regulatory elements, & gene expression from 213 human cell types

www.nature.com/articles/s41...

Paradoxical link between senescent cell state and liver cancer resolved DNA damage caused by a high-fat diet can increase the risk of tumour formation in the liver.

First 2025 metabolism publication in @nature.com is from Michael Karin's group, finding that metabolic hepatosteatosis promotes senescence of hepatocytes, but is bypassed through transcriptional inactivation of FBP1, a novel gatekeeper against hepatocellular carcinoma

www.nature.com/articles/d41...

The structure of bad cholesterol comes into focus High-resolution structures of low-density lipoprotein.

Both were covered in a great News & Views in @nature.com by Sean Davidson at U Cincinnati

www.nature.com/articles/d41...

The other by Zach Berndsen and Keith Cassidy took a novel approach by using AF2 and MD to look at how the many beta-sheets dynamically coordinate for different lipoprotein sizes (LDL vs VLDL).

www.nature.com/articles/s41...

Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor - Nature Cryo-electron microscopy structures of apolipoprotein B100 (apoB100) in complex with the LDL receptor (LDLR) provide insight into binding interfaces and explain how mutations in apoB100 or in LDLR can...

One by Joe Marcotrigiano and colleagues were able to visualize apoB-bound LDL with a ligand-binding domain of the LDLR, giving insight in to the binding and internalization of LDL particles

www.nature.com/articles/s41...

Two studies published recently in @nature.com proposed cryoEM structures of the lipoprotein apoB. Some of the biggest protein-lipid complexes ever visualized and some cool insights into lipoprotien bio.

Associate or Senior Editor, Nature Job Title: Associate or Senior Editor, Nature Locations: New York or Berlin (Hybrid working model) Application Deadline: December 15th, 2024 About Springer Nature Group Springer Nature opens the doors...

a great opportunity to join the Nature team: we're looking for a neuroscience editor, ideally with a strong record in systems neuro: springernature.wd3.myworkdayjobs.com/SpringerNatu...

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

We are delighted to share our latest findings in @natureportfolio.bsky.social! We describe cardiogenic regulation of sleep after cardiac injury.

www.nature.com/articles/s41...

Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...

Sleeping is one of my fav activities. Very excited that we got to share this study by @mcalpinelab.bsky.social showing that cardiac inflammation after a heart attack dictates sleep patterns and promotes healing/recovery.

www.nature.com/articles/s41...

Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis - Nature Innate IL-17-producing T cells—in particular, adipose γδ17 T cells—are enriched in molecular-clock genes, and the circadian expression of IL-17A and RORγt by these cells has a role in maintaining loca...

A great study by @lydialynch.bsky.social 's group showing that IL-17 producing immune cells in adipose dictate the circadian rhythm of that tissue and orchestrate de novo lipogenesis and systemic metabolism

www.nature.com/articles/s41...

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...

Very cool paper by Craig Thompon's group spearheaded by @keunwooryu.bsky.social identifying distinct subpopulations of oxidative and reductive mitochondria.

Can't wait to see everyone check their fav cell types for these populations!

www.nature.com/articles/s41...

NK2R control of energy expenditure and feeding to treat metabolic diseases - Nature In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as b...

First post! Didn't see this study on @bsky.app.

From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.

www.nature.com/articles/s41...

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!!

www.nature.com/articles/s41...

‘A place of joy’: why scientists are joining the rush to Bluesky Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.

‘A place of joy’: why scientists are joining the rush to Bluesky

For me, it certainly feels good to be here!

@natureportfolio.bsky.social @bsky.app

www.nature.com/articles/d41...