Deep Origin

Finding Promising Molecules and Biological Background With Balto | Deep Origin

See how we explored the KRAS G12D landscape and uncovered top candidate molecules — all without leaving the conversation. deeporigin.com/blog/finding-promising-molecules-and-biological-background-with-balto

#AI #Pharmaceuticals #DrugDiscovery #Bioinformatics

For more information on ARIA's AI Scientist programs: www.aria.org.uk/ai-scientist...

Interested in trying it out on your own:

Design molecules against targets: www.deeporigin.com/balto-ai-ass...

Extract molecules from the literature and patents: www.deeporigin.com/do-patent

Excited to join the AI Scientist program from ARIA! 🧬

With our predictive ADME-Tox models we're developing through @ARPA-H CATALYST, we're building a world where science is faster and more successful, leading to medicines sooner.

You can already try parts of this vision with Balto + DO Patent 👇

We Built a 98% Accurate Full Molecule Data Extractor for PDFs, Now You Can Use It | Deep Origin

We still redraw molecules by hand from PDFs in 2026.
That’s wild.
So we built DO Patent:
• 98%+ accurate full-molecule extraction
• PDFs → SMILES in minutes
• Confidence scores + source traceability
Try it free:
www.deeporigin.com/blog/we-buil...
#DrugDiscovery #Cheminformatics #AI #Biotech #Patents

We’re Leading an Up to $31.7M ARPA-H Contract Award to Build In-Silico Models To Replace Animal Testing | Deep Origin We’re thrilled to share that Deep Origin and our partners in the Pharmacological Research and Evaluation through Digital Integration and Clinical Trial Simulation (PREDICTS) consortium have been award...

Big news at Deep Origin: we’re leading a $31.7M ARPA-H award to build in-silico models that could replace animal testing.
Animal studies are slow, costly, and often fail to predict human biology.

Read more here 👉 www.deeporigin.com/blog/arpa-h-...

Out-of-the-Box GenAI for Medicinal Chemistry | Deep Origin What’s out there, what’s useful, what’s game changing

GenAI is getting better, but science needs more than text. Claude shows AI must use tools and real data—but chemistry is different: structures, pockets, ADMET, simulations. We dug into what GenAI can/can’t do for chemists + Balto’s 86% LitQA2 score below 👇

www.deeporigin.com/blog/out-of-...

Shout out to Deep Origin team member Aleks Grigoryan who wasn’t satisfied with just being proud of his team on the ground, but took it to the sky and made it loud! 🚀 🪂 🧬

Donate to Support Kate's Recovery and Journey Back Home, organized by Matt Shlosberg Help Bring Kate Home to Heal Dear friends, We are reaching out wi… Matt Shlosberg needs your support for Support Kate's Recovery and Journey Back Home

One of our much loved team members (and an all around great human being) Kate was in a horrible accident. If you have the means or time to share or contribute to her recovery fund, you will be helping to make the world a brighter place:

gofund.me/9553c9134

A Blind Spot in Drug Discovery: Pocket Finding | Deep Origin It’s been said a million times before but it’s worth re-emphasizing. Creating. a. new. drug. is. hard.

In our new blog post, we dive into:
🔺 Limits of global docking models
🔺 False positives & cryptic pockets
🔺 How Deep Origin PocketFinder (in Balto) boosts accuracy
🔺 >80% success in recovering real binding sites

www.deeporigin.com/blog/a-blind...

We're excited to be at #ARDD2025 — the premier conference focused on advancing therapies for aging and age-related diseases. As the field moves from breakthrough research to real-world impact, Deep Origin is here to explore the future of collab with biotech and pharma leaders shaping what comes next

Using our OncoSim toolkit—combining ML + mechanistic models across 1,000+ cancer cell lines—we’ve predicted 100+ novel synthetic lethal pairs. Some are validated and may guide therapy & resistance prediction.
Poster by Oliver Purcell @ GRC👇

www.deeporigin.com/academic-pos...

Feedback between F-actin organization and active stress governs criticality and energy localization in the cell cytoskeleton - Nature Physics Self-organized criticality can occur in cellular systems, but its origins remain unclear. Now it is shown that cytoskeletal criticality is influenced by the F-actin architecture and myosin active stre...

Thrilled to share our co-founder and CSO Garegin Papoian in Nature!

Actin cytoskeleton stores stress, unleashing sudden “cytoquakes”. Murrell @ Yale and Papoian @ UMD show orderly filaments diffuse force; tangled networks give power-law bursts.

Read more 👉 nature.com/articles/s41567-025-02919-4

This summer, we're is opening its doors in Yerevan to curious, driven, and technically skilled students for a 10–12 week paid internship in biosimulations and protein modeling.

Starts: End of June
Location: Yerevan, Armenia
Duration: 10–12 weeks
Paid internship

apply.workable.com/deeporigin/j...

We’ve developed a hybrid MM/NNP framework. It delivers high-accuracy solvation and binding ΔG predictions at an average throughput of ~600 ns/day on CPU—10× faster than GPU-based approaches.

Check out our scientific poster below 👇

www.deeporigin.com/academic-pos...

Can AI Agents Design and Implement Drug Discovery Pipelines? The rapid advancement of artificial intelligence, particularly autonomous agentic systems based on Large Language Models (LLMs), presents new opportunities to accelerate drug discovery by improving in...

DO Challenge — is a new benchmark designed to test autonomous agentic systems in a resource-constrained, simulated drug discovery environment.

We applied it to our own agentic system, Deep Thought, comparing its performance against human teams.

See what we found 👇

arxiv.org/abs/2504.19912

We had a great time at #ACSSpring2025! From presenting posters, to hosting a great happy hour, to seeing what's new in chemistry, the energy in-person is great!

We'll share our posters in the coming days. For now, stay in the loop by joining our newsletter! www.deeporigin.com/newsletter

Deep Origin Challenge has wrapped up! This year we had over 40 teams made up of over 110 talented programmers, students, data scientists, and life scientists in a 10-hour-long prediction challenge at our Yerevan office 🌄

Want to be involved next year? Stay informed 👉 www.deeporigin.com/newsletter

Democratizing Drug Discovery - Deep Origin Happy Hour · Luma Are you attending ACS Spring and looking for cutting-edge, AI-powered solutions to advance your research? Join the Deep Origin team for an evening of tacos,…

Headed to American Chemical Society Spring '25 expo? Join us Monday night for tacos, drinks, swag and a chance to try out Balto - our AI assistant for drug discovery - with some of the most fun scientists around!

Register below 👇

lu.ma/3sy7pqtb

Deep Origin Challenge 2025 Join us for the 2025 Deep Origin challenge

Last chance to sign up for the Deep Origin challenge!

🌄 A day-long AI/ML for drug discovery hackathon
🤝 Bring a team of up to 4 (or sign up yourself)
🤖 Meet and collaborate with leading ML and drug discovery experts
💵 Compete for cash prizes

www.deeporigin.com/events/deep-...

Smart distributed data factory volunteer computing platform for active learning-driven molecular data acquisition - Scientific Reports Scientific Reports - Smart distributed data factory volunteer computing platform for active learning-driven molecular data acquisition

New pub from our team - check out our Smart Distributed Data Factory (think SETI@Home but for molecules) below 👇

www.nature.com/articles/s41...

Want to download the DFT dataset or volunteer compute to create new DFT data points for the community? Find out more here: sddfactory.cloud

Deep Origin Challenge 2025 Join us for the 2025 Deep Origin challenge

The #DeepOriginChallenge is back! Join us in our Yerevan office for a day of competition and collaboration building efficient #machineLearning models in small teams. Prizes up to $3k and the promise to meet leaders in AI and drug discovery.
Register below!

Aram Davtyan giving an awesome poster presentation about our work modeling protein-small molecule-protein ternary complexes at @keystonesymposia.bsky.social Proximity-Based Therapeutics! #biotech #drugDev #degraders #molecularGlues #PROTACs

Find the poster here: www.deeporigin.com/academic-pos...

JPM ‘25 From the Trenches: AI in Biotech Gets Tactical | Deep Origin Our take on the biggest trends and best observations at JPM '25

Miss #JPM? Not enough eyes and ears to take it all in? Here's our download of what's coming up in #biotech for 2025 👇

www.deeporigin.com/blog/jpm-25-...