Sarah Yip

Important call for action on the integration of research programs across species. Meaningful progress in the brain sciences will require cross-field collaborations and research that spans human and non-human animal models.

Me getting to know a new dataset...

Coding with AI - Better Code, Better Science

My new chapter of Better Code, Better Science on AI-assisted coding is now complete! It's been completely revised in an attempt to futureproof it. Comments welcome. bettercodebetterscience.github.io/book/ai-codi...

If you work at the intersection of computational neuroscience and machine learning, consider applying for this postdoc position (January 2027 start date):
academicpositions.harvard.edu/postings/15868
An opportunity to work with a great group of people across Harvard, MIT, and UC Berkeley.

Mental health is shaping survival after heart disease—yet we rarely treat it that way. A new meta-analysis of 22 million people links PTSD, anxiety, depression & insomnia with higher risk of acute coronary syndrome. jamanetwork.com/journals/jam...

🌟 Job alert! We are looking for a postdoc to join a multidisciplinary research team working on the Individually Measured Phenotypes to Advance Computational Translation at Yale (IMPACT-Y) study.
postdocs.yale.edu/posts/2026-0...

The postdoctoral associate will lead and contribute to the analysis of behavioral task data using computational modeling approaches, working closely with me, @robbrutledge.bsky.social, and with IMPACT-Y leadership,
Drs. @yiplab.bsky.social, Chris Pittenger and Godfrey Pearlson.

Thanks Avram!!

Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain - PubMed The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in neuropathic pain states. Here, we aimed to study inhibitory parvalbumin positive (PV+) posterior insula (pIC) to posterior ACC (pACC) projections, and to evaluate the effects of …

Neuro friends: Any one ever try tract-tracing studies in the insula or cingulate (in rats or mice) and find a connection there? It keeps showing up in resting-state studies and outside of pIC to pACC inhibitory projections here (pubmed.ncbi.nlm.nih.gov/37605272/), I can't find much else!

To apply email xiaosi.gu@yale.edu!!

Looking for a postdoc in #computationalpsychiatry? Apply here to join an interdisciplinary team and work with a large longitudinal transdiagnostic dataset

postdocs.yale.edu/posts/2026-0...

@RobbRutledge @xiaosigu @DrChrisPitt @PearlsonGodfrey @ACNPorg @YaleMed

Computational Psychiatry Conference New Haven, USA (July 14-16, 2026)

🔥🔥SAVE THE DATE!!🔥🔥

Join us at Yale for the 2026 Computational Psychiatry Conference July 14-16, 2026 www.cpconf.org

@xiaosigu.bsky.social @yiplab.bsky.social @shirleybwang.bsky.social @alpowers7.bsky.social

See you in New Haven!

Awesome work here from @ariellekeller.bsky.social er.bsky.social linking the exposome to the developing functional connectome—check it out!!

www.biorxiv.org/content/10.1... 1/2

Happy New Preprint Friday!* Thrilled to share new results in collab with Sarah Lichenstein & @yiplab.bsky.social showing our brain's functional connections reflect the environments we grow up in!
tinyurl.com/exposomeConnectivity

#neuroskyence #PsychSciSky #DevPsy #cognition
*can this be a thing??

Amazing opportunity to work at the intersection of complex clinical psychiatry and advanced neuroimaging research!!!

Been thinking for a few years about what I call the *replication ceiling*: the maximum replicability of an effect given constraints in data in which replication takes place (power, measurement error, sampling variability, etc). This leads to a maximum theoretical replicability which can be achieved.

Take a look at our paper! Led by @francimandi.bsky.social in the Lake lab: "Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice" !!!!

www.biorxiv.org/content/10.1...

Really interesting, brief ideas paper. Clearly relevant to treatment research-- the mechanism by which you leave an illness state is unlikely to just be the opposite of the mechanism by which you entered it (can see how this might apply to e.g. SSRIs in depression).

Check out the latest work from this superstar team to learn how you can go from big data to small data with transfer learning to advance precision psychiatry!

🧠

Anybody else worried that because of the long standing Republican war on SNAP people are going to experience painful hunger. Lets do something. @nanopharmnc.bsky.social and i are going to donate to some local nc food banks. Join us! Gonna match up to $500.

From big to small: Emerging methods for enhancing precision psychiatry through transfer learning Identifying reliable links between individual differences in neurobiological features and differences in symptom profiles or treatment outcomes is a primary goal of precision psychiatry. Within this c...

Excited to share this review in @biologicalpsych.bsky.social on using transfer learning to leverage large MRI datasets & enhance precision psychiatry!!

www.biologicalpsychiatryjournal.com/article/S000...

Fun collab with rockstars @diawang.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social

😅

Postdoctoral Associate Position — Child Study Center, Yale School of Medicine — The BABL Lab Title of the Position: Postdoctoral Associate

Interested in the maternal brain and addiction? @yiplab.bsky.social and I are hiring a postdoc to work on our study examining psychosocial and neural markers of stress during the perinatal period in moms receiving treatment for OUD. See link for more details: postdocs.yale.edu/posts/2025-1...

New paper in Imaging Neuroscience by Sam Laxer, Ravi S. Menon, et al:

A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques

doi.org/10.1162/IMAG...

Interested in the mechanisms shaping the extraordinary complexity of the connectome?

Then check out our new preprint, lead by
Francis Normand with a stellar team, showing how geometry constrains connectome architecture:

biorxiv.org/content/10.1...

Full thread here:
tinyurl.com/sfv3yf73

Great collaboration with amazing scientists across multiple countries! Hugh Garavan @toddc.bsky.social @coreyhorien.bsky.social Sarah Lichenstein @baderchaarani.bsky.social Godfrey Pearlson and the IMAGEN consortium

Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth - Molecular Psychiatry Molecular Psychiatry - Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth

New paper from @annierhcheng.bsky.social

using data from IMAGEN and ABCD she identifies distinct signatures of impulsivity and negative affect in youth that uniquely overlap with a neuromarker of risky alcohol use

#development #equifinality #abcd #connectome

www.nature.com/articles/s41...

The Biological Psychiatry family of journals is now officially on Bluesky!

Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.

A fresh, new @npp-journal.bsky.social paper from @yiplab.bsky.social & @lester-rodriguez.bsky.social is out now 👇

Connectome-based encoding of subjective drug responses to acute oral methamphetamine - Neuropsychopharmacology Neuropsychopharmacology - Connectome-based encoding of subjective drug responses to acute oral methamphetamine

Massive congrats to @lester-rodriguez.bsky.social for his 1st (of many!) 1st authored paper!!!

Identification and external replication of a neuromarker of subjective drug effects to acute methamphetamine (vs placebo)!!!

nature.com/articles/s41...

@npp-journal.bsky.social