Cool!!
20.02.2026 14:48 — 👍 0 🔁 0 💬 0 📌 0Cool!!
20.02.2026 14:48 — 👍 0 🔁 0 💬 0 📌 0There's a lot we still don't know about BEC heterogeneity! But hopefully this manuscript provides a foundation for our lab and others to keep pursuing questions related to how different BEC subpopulations respond to changing physiological conditions in liver health and disease.
16.02.2026 22:29 — 👍 0 🔁 0 💬 0 📌 0Validating our candidate metagenes in situ yielded some cool spatial observations and provided a high-confident approach for matching control and injured BEC clusters for subpopulation-specific differential expression analysis.
16.02.2026 22:29 — 👍 0 🔁 0 💬 1 📌 0
...but how could we apply this panel of 7 genes as usable BEC subpopulation biomarkers? Kendall developed a 9-color RNA FISH panel, capable of identifying both enrichment of an "on target" metagene and de-enrichment of all other "off target" metagenes (also capable of making pretty images)
16.02.2026 22:29 — 👍 0 🔁 0 💬 1 📌 0
Bc of this transcriptional similarity, most differentially expressed genes were expressed across all BEC clusters, just at slightly variable levels. To identify cluster-specific biomarkers, Kendall applied "metagenes", mostly consisting of two overlapping genes to define a candidate subpopulation.
16.02.2026 22:29 — 👍 0 🔁 0 💬 1 📌 0
scRNA-seq has been powerful for cell-cell heterogeneity in other systems, but liver atlases present BECs as a single population with little apparent transcriptional diversity. We observed that injury and hepatocyte identity were the only major drivers of "distinct" clusters in our own data.
16.02.2026 22:29 — 👍 1 🔁 0 💬 1 📌 0Now that we're settled at @unc-cbp.bsky.social I'm excited to share the lab's latest preprint tinyurl.com/y8755f2n From 1st author Kendall Kanakanui (@kkanak.bsky.social an @emory-gmb.bsky.social student) it represents a years-long effort to define heterogeneity among biliary epithelial cells (BECs)
16.02.2026 22:29 — 👍 3 🔁 1 💬 1 📌 0
Happy International Day of Women & Girls in Science! Today & everyday I am grateful for the opportunity to work alongside & learn from this talented group of women scientists. Funded by grants from the NIH, this team is working to understand how the gut microbiome affects our digestive health.
12.02.2026 02:36 — 👍 14 🔁 3 💬 1 📌 0
In our new poll with the Boston Globe of NIH funded scientists in Mass ...
- 72% say they have delayed or cancelled projects
- 66% reduced research scope
- 56% paused experiments or students.
www.bostonglobe.com/2026/02/09/m...
Microscopy image of a kidney only showing the highly branched arterial tree in magenta against a black background.
The beauty of the kidney arterial tree for this #FluorescenceFriday. Evans Blue dye labels the vasculature. Image courtesy of postdoc Sarah McLarnon.
06.02.2026 22:16 — 👍 87 🔁 15 💬 0 📌 0
My department at Washington State University is recruiting an Assistant or Associate Professor in vector-borne disease 🕷️🦟🦠
Full job description is linked below.
Come join us on the Palouse!
Wiley: "We’re supporting responsible research assessment practices" onlinelibrary.wiley.com/journal/1520...
Also Wiley: "Prove that your article is a good fit for this journal 😉😉😉😉😉 by citing at least two of our articles in your manuscript before we will even consider reviewing it" 🤡
I heard a lot of similar stories last year, and more this year. Lots of 4th rotations. This is devastating for the future of science. We reject many superb applicants to PhD programs every year, because spots are limited. Now we struggle to find labs for admitted students.
31.01.2026 01:37 — 👍 7 🔁 4 💬 0 📌 0
Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s
www.cell.com/cell/fulltex...
I'm at the Willard Hotel where I've been denied entry and kicked out of the Reclaiming Science event with NIH director Bhattacharya & other top agency leaders.
@jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.
If you, as a scientist, cannot be bothered to engage in the intellectual work of science, please quit your job and leave it to someone with skill and integrity.
28.01.2026 05:11 — 👍 160 🔁 49 💬 1 📌 1Whoa…interesting
27.01.2026 21:03 — 👍 2 🔁 0 💬 0 📌 0💔
27.01.2026 01:42 — 👍 0 🔁 0 💬 0 📌 0The constant succession of administrative crises undermining science in the US is exhausting.
22.01.2026 20:22 — 👍 2 🔁 1 💬 0 📌 0
FY26 was the hardest LHHS bill I’ve ever worked on. After a year spent witnessing this administration tear apart and eliminate entire federal programs that millions of Americans rely on, our bill re-establishes and increases funding for many of them. It provides a $415 million increase for The National Institutes of Health, among many important others, and ensures that investment results in more research grants being awarded. This bill is the culmination of an incredibly long, frustrating, exhausting negotiating process of late and sleepless nights. It always is. But this year was different for all of the obvious reasons. There were moments we didn’t think we could possibly get it done. I’m proud we kept up the fight until the bitter end because what we achieved is pretty damn impressive. Did we get everything we wanted? No, it’s never enough. That’s why it’s a compromise. But there are a number of bright spots sprinkled throughout the final product that matter. The most important is that Congress is finally reasserting its power of the purse. 💰 Hope is on the horizon. So let’s go, we’re ready for year 2.
From Meghan Mott on LinkedIn
1/2
The language on multiyear funding (MYF) is ineffective.
Final bill anchors MYF to 2025 instead of 2024. This means MYF will likely continue at the same rate we saw last year, where NCI's payline from ~10% to 4%.
This is incredibly harmful to the US research workforce - especially early career.
FINALLY out in AJPath - the second manuscript from @hannahhrncir.bsky.social’s PhD at Emory! Hannah developed a novel pipeline for quantitative 3D light sheet microscopy of bile ducts that will hopefully be a great resource to the community. ajp.amjpathol.org/article/S000...
20.01.2026 11:54 — 👍 4 🔁 1 💬 0 📌 0HUGE problem!
19.01.2026 23:29 — 👍 1 🔁 0 💬 0 📌 0‼️
14.01.2026 14:01 — 👍 0 🔁 0 💬 0 📌 0I still think if you have a completed story you believe is ready to submit then there is no disadvantage to pre-printing. We always pre-print first and then decide where to submit. As stressed above this in effect mitigates ‘scooping’. Revision requests in every field have got out of control.
13.01.2026 08:21 — 👍 14 🔁 4 💬 2 📌 0When I was the DGS of an umbrella-type PhD program, I worked to put in a rule that PhD students needed a minimum of one 1st-author research paper to graduate. The main intent was to protect students from advisors that were slackers about publishing. No 1st-author pubs really hurts students. 1/3
09.01.2026 01:44 — 👍 4 🔁 1 💬 2 📌 0
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
The suitability of different AAV capsids for gene therapy is assessed in human livers go.nature.com/3PWpD4o
rdcu.be/eUK3m
Can’t wait for this one!
11.12.2025 17:24 — 👍 1 🔁 0 💬 0 📌 0