A miniature CRISPRβCas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
01.10.2025 17:56 β π 108 π 54 π¬ 3 π 2
Nice write up by Kalani Gast and Rodolphe Barrangou previewing our latest paper 𧫠βοΈ π§¬ out now in @cp-cellhostmicrobe.bsky.social
15.09.2025 21:02 β π 1 π 0 π¬ 0 π 0
Applied research is digging for gold, basic research is figuring out where to dig. Marsden used to fund it all. Each grant is rigorously assessed in 2 rounds by a panel of local & international experts. It is risky research, with potentially high rewards.
06.09.2025 21:35 β π 37 π 15 π¬ 2 π 1
Type I CRISPR-Cas immunity primes type III spacer acquisition
CRISPR-Cas systems are diverse, with microbes harboring multiple classes and subtypes. Type I DNA-targeting and type III RNA-targeting systems often cβ¦
In a multi-CRISPR-Cas system host, @peterfineran.bsky.social & I found that type I priming promotes spacer 𧬠uptake & maintenance by a type III system & that multiple systems minimize phage escape β¬οΈ @cp-cellhostmicrobe.bsky.social @otagomicroimmuno.bsky.social
www.sciencedirect.com/science/arti...
20.08.2025 02:06 β π 6 π 3 π¬ 0 π 0
Still open for applications! We are looking for prospective new faculty doing exciting research in virology or any vector borne diseases
25.07.2025 23:04 β π 4 π 9 π¬ 0 π 0
Conference flyer, all info is on link too
Please share! π¦
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.
Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...
#MicroSky
22.07.2025 19:03 β π 15 π 13 π¬ 2 π 0
Next up from our lab - a ring nuclease with a novel fold which cleaves all cOA species involved in Type III CRISPR defence. It's also found in plasmid and phage genomes, where it presumably functions as an anti-CRISPR.
www.biorxiv.org/content/10.1...
18.07.2025 07:53 β π 42 π 14 π¬ 3 π 1
Great to see this comprehensive work on phage DNA arabinosylation & defense finally out! π§¬π«βοΈ A major collaborative effort & stellar PhD work by Marina Mahler, whom I had the pleasure of co-supervising at Otago π©π»βπ¬ @peterfineran.bsky.social @universityofotago.bsky.social @cellpress.bsky.social #mm
26.06.2025 22:44 β π 8 π 1 π¬ 0 π 0
International Society for Viruses of Microorganisms (ISVM) aims to advance the science and use of viruses of microorganisms by supporting academic meetings, encouraging networking, and facilitating learning opportunities
Prof. and Head of Phage-host interactions (Phi) lab. Phage defences, counter-defences, CRISPR-Cas, toxin-antitoxin. FRSNZ / James Cook Fellow
Senior Scientist and Bioinformatician at the New Zealand Institute for Bioeconomy Science | Helping improve agriculture in Aotearoa New Zealand
Department of Microbiology and Immunology at the University of Otago
Microbiology Society: A world in which the science of #microbiology provides maximum benefit to society | microbiologysociety.org
lnk.bio/microbiosoc
Nature Microbiology publishes the latest research and commentary in all areas of microbiology.
https://www.nature.com/nmicrobiol/
Professor of Microbial Ecology and Evolution at the Life Sciences Department at the University of Bath. Royal Society Dorothy Hodgkin Research Fellow. Children's author evolution/genetics. Mum.
https://tiffanybtaylor.wordpress.com/
Microbial evolution / University of Manchester
University of Pittsburgh School of Medicine | PhD Graduate Student | All Things Phage-Host Interactions & Antibiotic Resistance π§«π¬
Cell Press partners with scientists across all disciplines to publish and share work that will inspire future directions in research. #ScienceThatInspires
The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
Nucleic Acids Research (NAR), from Oxford University Press, publishes the results of leading-edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions
Harvard Systems Biology PhD in the @baym.lol lab. Fan of science and sports. Not necessary in that order
Research, news, and commentary from Nature, the international science journal. For daily science news, get Nature Briefing: https://go.nature.com/get-Nature-Briefing
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BBSRC Discovery Fellow, University of Exeter, Cornwall UK.
Microbial ecology and evolution, plant-microbe interactions, mobile genetic element-defence system interactions, Azospirillum sp
