Ivaska Lab

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!

www.nature.com/articles/s41...

@omkarjoshi.bsky.social @hellyeh-h.bsky.social @mathildemathieu.bsky.social @johannaivaska.bsky.social

The dynamic tumor extracellular matrix: Biophysical cues, cellular crosstalk, and disease progression The interplay between diverse cell types and their extracellular matrix (ECM) is fundamental for multicellular life. The ECM is a complex meshwork of …

Review alert! Our new review titled 'The dynamic tumor extracellular matrix: Biophysical cues, cellular crosstalk, and disease progression,' is now online!

Congrats to all the authors! Link: tinyurl.com/bdh6zzzp

18 days left to apply! come join our lab!

Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!

Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028

🚨 Job Alert! 🚨

We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇

abo.rekrytointi.com/paikat/index...

#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social

I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!

Reach out if you are interested 👍

There is a permanent positon open at our centre. Read more & apply 👉 ats.talentadore.com/apply/erikoi...

Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...

We are very happy to share our latest work exploring the role of newly synthetized integrin-α5 using RUSH. We found that a subset goes to the PM via unconventional secretion! Big thanks to all involved! Read more at doi.org/10.1083/jcb.... @mathildemathieu.bsky.social @martina-lerche.bsky.social

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

Happy to see this dynamic micropatterning project taking its beautiful shape as a preprint!

Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩

Adapting an amazing tool from @ivaskalab.bsky.social 💥

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

Latest from Ivaska Lab ▶️ Niklas Jäntti et al delve deep into the roles of EPLINα/β on integrin trafficking and breast cancer outcomes!

Congratulations to all the authors!

Check the paper out here: www.sciencedirect.com/science/arti...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

If you are at the FEBS Congress in Istanbul and would like to have a chat about adhesion-derived protein condensates come to see my poster today between 12:30-13:45. Looking forward to inspiring discussions! 🔬

@ivaskalab.bsky.social

Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!

MI/25/33 - Postdoctoral Scientist Systems Oncology Group | Cancer Research UK Manchester Institute Add brief description here

We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out

1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados

Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää.

Miten syöpäsolut leviävät ja voidaanko sitä estää? Toistaiseksi ei, mutta tämä saattaa muuttua. Turun biotiedekeskuksen tutkijat löysivät keinon avata syöpäsolujen viestintää, ja tämän tiedon kautta saattaa löytyä lääke syöpäsolujen pysäyttämiseen.

@ivaskalab.bsky.social @johannaivaska.bsky.social

New visualisation tool helps researchers to target breast cancer dissemination Cancer cell movement during metastasis is a dynamic process regulated by several different signals.

Signaling networks inside #cancer cells control everything from growth to movement, but visualising this in living cells requires new and refined methods. Researcher James Conway set out to see these invisible signals and came up with a new tool to do just that.
#Illusia
@ivaskalab.bsky.social

Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa - InFLAMES-lippulaiva Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää. Menetelmä on paljastunut, että muihin syöpätyyppeihin parha...

Syövän nykyisillä lääkkeillä ei voida estää syövän leviämistä. Tilanne saattaa muuttua, sillä tutkijamme ovat kehittäneet tavan kuvata syöpäsolun sisäistä signalointia, joka on edellytys solun liikkumiselle.
#Illusia
@johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social

New visualisation tool helps researchers to target breast cancer dissemination - InFLAMES Research Flagship Cancer cell movement during metastasis is a dynamic process regulated by several different signals. However, the way cells receive, process and respond to these signals has been extremely hard to dete...

In a new study led by InFLAMES PI Professor Johanna Ivaska and Dr James Conway have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells which they used to uncover a new therapeutic possibility for limiting breast cancer spread.
#Illusia
@ivaskalab.bsky.social

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!

Read more at:

www.nature.com/articles/s41...

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

Syöpätutkija Johanna Ivaskalle 100 000 euron tiedepalkinto Ivaskan työryhmä tutkii syöpäsolujen liikkumista ja leviämistä.

www.is.fi/kotimaa/art-...

Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize
thanks to all my international friends and colleagues over the years

We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!

Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!

Adhesion-derived condensates control component availability to regulate adhesion dynamics Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...

This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social