Eden Bernstein

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The effects of glucagon-like peptide-1 receptor agonists (GLP1-RAs) on alcohol-related outcomes: a systematic review and meta-analysis - Addiction Science & Clinical Practice Objective To evaluate the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on alcohol-related outcomes in adults with or without alcohol use disorder (AUD). Methods A systematic review ...

Based on findings from a recent meta-analysis in ASCP:

Distilling the evidence for GLP-1 receptor agonists in alcohol use disorder - Addiction Science & Clinical Practice Addiction Science & Clinical Practice -

Check out our new editorial for the latest on evidence for GLP-1’s for the treatment on alcohol use disorder

Alcohol-Related Hospitalizations From 2016 to 2022 This cross-sectional study examines US trends in the rate and outcomes of alcohol-related hospitalization from 2016 to 2022 using data from the National Inpatient Sample.

In our national study of hospitalizations from 2016-2022, we describe overall stable rates of alcohol-related hospitalizations but increasing inpatient mortality, length of stay, patient complexity, and cost. Just published in @jamanetworkopen.com👇

Variation in initiation of medications for alcohol use disorder during alcohol withdrawal hospitalizations in a large health system: A retrospective cohort study Background Alcohol withdrawal hospitalizations present unmet opportunities to initiate medications for alcohol use disorder (MAUD). Objective To examine patient and hospital factors associated wit...

🚨Our new paper in @jhospmedicine.bsky.social describes large hospital-level variation in initiation of medications for alcohol use disorder during alcohol withdrawal hospitalizations. Huge opportunity for increasing uptake of evidence based treatment! @cudivhospmed.bsky.social

Hospitalization Is a ‘Missed Opportunity’ to Treat Substance Use Disorder A study by CU Department of Medicine faculty shows nearly one in 10 people with SUDs are hospitalized in a year, yet disorder treatment often isn’t available.

Nearly one in 10 people with substance use disorders are hospitalized in a year, yet disorder treatment often isn’t available, says a new study by @cudeptofmedicine.bsky.social faculty @edenbernstein.bsky.social, Gina Kruse, MD, and Susan Calcaterra, MD, MPH. @cuanschutz.bsky.social #cucityofhealth

Bottom line: Both are great (and underutilized!) options to initiate for AUD at hospital discharge. As with everything, would heavily consider local factors and patient preferences in decision-making, but if adherence to pills is a barrier then injectable naltrexone might be a good choice

Both strategies resulted in post-hospitalization reduction in drinking. While there was no significant difference in drinking outcomes btw groups, adherence was better in the injectable arm.

Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder This randomized clinical trial compares the effectiveness of initiating oral naltrexone vs extended-release injectable naltrexone on reduction in alcohol use and health care utilization among medical ...

Excellent trial comparing oral vs injectable naltrexone at hospital discharge 👇

Grateful for support from coauthors and mentors from @cudivhospmed.bsky.social @cudeptofmedicine.bsky.social and @yaleadm.bsky.social

Unfortunately, most hospitalized patients with substance use disorders don't receive evidence-based treatment. These findings highlight that this is a missed opportunity to help millions of people each year ‼️

Those who were hospitalized were unsurprisingly older and had more medical and psychiatric co-morbidities compared to those who weren't.

However, given the underlying prevalence of substance use disorders, tobacco and alcohol use disorders accounted for the largest overall prevalence of hospitalizations.

Hospitalizations were common! 10% of adults with SUD reported past-year hospitalizations including nearly 1 in 4 of those with opioid use disorder.

We used a national survey (NSDUH) to identify US adults with substance use disorders in 2022 and describe their self-reported prevalence of past-year hospitalizations.

Prevalence of Hospitalizations Among a National Sample of U.S. Adults With Substance Use Disorders | Annals of Internal Medicine

Hospitalizations present unmet opportunities for addiction treatment engagement. Our new paper in @annalsofim.bsky.social describes the prevalence of hospitalizations among adults with substance use disorders to inform the reach of hospital-based addiction treatment programs🧵

Association of Medicare Advantage vs Traditional Medicare with Clinical Outcomes Among Patients Hospitalized for Substance Use Disorders - Journal of General Internal Medicine Background Medicare Advantage (MA) includes incentives to reduce health care spending and insures over half of Medicare eligible adults. Substance use disorders (SUD) are common in this population. Ob...

👋 #Medsky
Check out our new paper on differences in post-hospitalization outcomes between Medicare Advantage and traditional Medicare beneficiaries with alcohol withdrawal and opioid overdose

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

New @thelancet.bsky.social Editorial - American chaos: standing up for health and medicine

www.thelancet.com/journals/lan...

#MedSky #GastroSky

Excited to share our perspective in @nejm.org led by @trishasantos.bsky.social & @fabioethics.bsky.social
Texas GA-46 threatens confidentiality and trust between clinicians and immigrants. We must advocate to protect privacy and ensure hospitals remain safe spaces.

Great to chat with @markharden.bsky.social about the link between alcohol and cancer in light of the recent surgeon general advisory!

Things We Do for No Reason™: Avoiding naltrexone for alcohol use disorder in liver disease Hospitalizations related to alcohol use disorder (AUD) are common. Yet, few patients receive pharmacotherapy consistent with guideline recommendations. Previous concerns over the potential hepatotoxi...

Great summary of evidence for safety of naltrexone in liver disease 👇

a penguin with a broken egg shell on its head is saying hello ALT: a penguin with a broken egg shell on its head is saying hello

We're making moves. Hello, Bluesky! 👋

Impact of alcohol use disorder on inpatient hospitalizations: A comparison of outcomes between urban and rural Veterans Affairs hospitals Background Alcohol use disorder (AUD) is a leading cause of morbidity and mortality that disproportionately affects rural residents and Veterans. Objective To evaluate the burden of AUD in admissi...

🚨1 in 3 patients admitted to a VA with #AlcoholUseDisorder die in 5 yrs, with disproportionally high admissions in rural areas.

Study by #Hospitalist Dr James Willey reinforces need for urgent action to address AUD in the veteran population.

shmpublications.onlinelibrary.wiley.com/doi/full/10....