Luisa Demarchi

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠

www.nature.com/articles/s41...

Enjoying the gala dinner and the beautiful city of Bordeaux last night, w/ @luisadema.bsky.social @jordanmarrocco.bsky.social @cate-cholamine.bsky.social @bohaceklab.bsky.social @ebbsociety.bsky.social #EBBS2025

Welcome party #EBBS2025 @ebbsociety.bsky.social so happy to catch up with my former PhD student @luisadema.bsky.social along with my current @annika-koeck.bsky.social

The end of the semester lab lunch in Zero Otto Nove... Saying goodbye to our students Anaya, Fletcher, and Liz... with a visit from the lab alumnus Eric.. Always having a great time with these wonderful young people! ❤️ w/ @luisadema.bsky.social @lailaouldibbat.bsky.social

My lab is hiring 2 postdocs on an NIH-funded grant characterizing molecular & cellular changes in the human brain across menopausal transition. Other neuroepigenomics projects are also available. We plan to hire a wet lab scientist and a bioinformatician. Please RT!
kundakoviclab.com
More info 👇

Had a wonderful evening celebrating my promotion to full professor with my lab members & alumni. Thank you all for shining so brightly, for the fantastic work that you do, and for being part of this amazing journey! ❤️ @luisadema.bsky.social @lailaouldibbat.bsky.social

The mothers also showed increased passive stress-coping behavior and elevated corticosterone.
One of the most interesting finding was that blocking CRF receptors helped alleviate this altered stress-coping behavior, pointing to the CRF system’s important role in emotional effects of offspring loss.

In this study we explored the long-term emotional and neurobiological consequences of offspring loss in rats. We found that mothers who lost their pups had increased OXT-R binding in key brain region involved in maternal bond, along with a decrease in dendritic spine density.

Very happy to share that the last data from my PhD is now available as a preprint! Huge thanks to @olibosch.bsky.social @alicesanson.bsky.social and all my former colleagues for their support throughout this journey.
www.biorxiv.org/content/10.1...

Thank you Ali!! 😍

Thank you, Oliver!!

Congratulations!!

The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice Ovarian hormones, particularly estradiol, play an important role in the regulation of metabolic function including in food intake, thermogenesis, acti…

Excited to share Laila’s @lailaouldibbat.bsky.social first first-author paper & the very first “metabolic” paper from the lab just published @ Hormones & Behavior:

"The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice"

www.sciencedirect.com/science/arti...

Revisiting sex and gender in the brain To conduct scientifically accurate and socially responsible research, think of “sex” as a complex, multifactorial and context-dependent variable.

Thrilled to share my perspective in "The Transmitter" @thetransmitter.bsky.social on how to study the influence of "sex" and "gender" in the brain in a scientifically accurate and socially responsible manner:

"Revisiting sex and gender in the brain"

www.thetransmitter.org/sex-differen...

After 5 years of data collection (179 first-time mothers + controls), the first bemother.eu/en/ paper is out! We uncovered a U-shaped trajectory in maternal GM volume, resolving a long-standing puzzle in the maternal brain field. www.nature.com/articles/s41...

Just received a wonderful Christmas gift from the NIH! $2.76M to study molecular & cellular changes in the human brain across the menopausal transition! 🎉 Am icredibly excited! We will be hiring 2 postdocs — come join us in NYC for some cool science, as we transform women’s mental health research!!

New open access paper out in Neuropharmacology!
@alicesanson.bsky.social shares another piece of the puzzle about the role of the #CRF and #oxytocin systems in the nucleus accumbens shell (NacSh) in the postpartum period. You can read it here: doi.org/10.1016/j.ne...

Lab lunch today to welcome our new postdoc Ana Milosevic and to celebrate many recent B-days and accomplishments in the lab. Very proud of this amazing group of young scientists. Stay tuned for several cool papers coming from the lab soon! 🔥 w/ @luisadema.bsky.social

#OlafurEliasson exhibition in NYC. If you want to awaken your senses, this is the perfect place ✨

OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr

Thanks!

Pup defence in lactating rats: The underlying neuropeptide signalling and their interactions in the nucleus accumbens shell Maternal aggression is a core feature of rodent maternal behaviour to defend their offspring from potential threats and is modulated by corticotropin-releasing factor (CRF) and oxytocin (OXT) systems ...

Long story about the nucleus accumbens in short:
- Infusion of CRF, UCN3 or oxytocin antagonist in the shell impaired maternal aggression
- Oxytocin release increased during maternal aggression
👇🧵👇
www.biorxiv.org/content/10.1...

Can you add me? I would love to join! :)