Lesley Mac

What Have They Done Now? A Demolition Brother's Update

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Kids Will Use AI A clear guide to help students (and teachers) use AI tools wisely.

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7 Halloween Contests That I Didn't Know Existed Everything is a competition for the Demolition Brothers!

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Kids Will Use AI A clear guide to help students (and teachers) use AI tools wisely.

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What Have They Done Now? A Demolition Brother's Update

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Demolition Brothers Head Back to School And right on cue, my plans are foiled by life.

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How Not to Imagine Every Possible Mishap Still Working on It…Demolition Brothers Debacles Never Disappoint

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How Not to Imagine Every Possible Mishap Still Working on It…Demolition Brothers Debacles Never Disappoint

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Demolition Brothers Head Back to School And right on cue, my plans are foiled by life.

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Instilling Analog Values in Digital Kids Screens are our biggest asset and strongest nemesis.

Hide-n-seek has never been such fun or necessary!

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Top 5 Activities I Loved as a Kid That Send Me Straight to the Panic Zone As a Parent

Happy Tuesday! Hope you enjoy my latest installment.
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Buckle up!
Turns out dodgeball was never about gym class glory.
It was training for the things they never mention in driver’s ed.

Buckle up!
Turns out dodgeball was never about gym class glory.
It was training for the things they never mention in driver’s ed.

Toy riding mower stacked on top of a kiddie chair on top of a dining chair. (Picture by Author)

Hope everyone staying cool!
The demolition brothers take on the heatwave in this week's Chasing Safety.
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Newest Chasing Safety
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Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age Nature Communications, Published online: 07 July 2025; doi:10.1038/s41467-025-60975-zAging leads to progressive loss of effective tissue regeneration, which has been linked to the accumulation of senescent cells. Here, the authors use machine learning to identify a stable nuclear morphometric phenotype that detects senescent cells across tissues and age, enabling their quantification and mapping in diverse environments.

Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age @natcomms.nature.com

Puppy Dog Eyes and Long Goodbyes When Natural Separation Sparks Anxiety

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Only Put FOOD in your Mouth! When Curiosity Tastes Like Trouble

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Check out Chasing Safety's New Post. What dares do I have to worry about next?

Chasing Safety: DIY Dishwasher Repair The Why? Guy Strikes Again!

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This Week’s Demolition Brothers Debacle: Beef Sticks and a Ball Chasing Safety means encouraging independence - and managing the panic as they speed ahead on two wheels.

If you enjoy learning the best ways to:
-wipe glue off appliances
-unclog drains full of oobleck
-stay sane while parenting and renovating...Check out my new post!
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The Demolition Brothers Revolution Parenting ADHD (Adorably Dynamic Hyper Dudes)

Chasing Safety: Hitting the trails isn’t just a hobby for my Adorably Dynamic Hyper Dudes! It’s how we stay grounded on our family’s ever-winding ADHD journey.
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Lesley Mac | Substack Former nonprofit director turned accidental stay-at-home mom, now chasing two wildly energetic sons—grasping at safety and survival through humor. Currently navigating renovations and searching for a ...

Lesley Mac -The Daily Debacle chasingsafety.substack.com?r=5m6prc&utm...

Chasing Safety: From Laid Back Lesley to Safety Zombie Meet the Demolition Brothers (and Their Formerly Calm Mom)

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The Demolition Brothers' "Mad, Mad Bo Bad" Mom And Other Unexpected Pet Peeves

I’ve never considered myself especially peeved at much — more “mildly annoyed, rarely ruffled.” But parenthood has a way of uncovering new depths of daily absurdity. From sprained thumbs to sticky glass tables, here are a few surprisingly specific pet peeves I didn’t see coming.

Puppy Dog Eyes and Long Goodbyes When Natural Separation Sparks Anxiety

open.substack.com/pub/chasings...

Only Put FOOD in your Mouth! When Curiosity Tastes Like Trouble

open.substack.com/pub/chasings...
Check out Chasing Safety's New Post. What dares do I have to worry about next?

The Demolition Brothers' "Mad, Mad Bo Bad" Mom And Other Unexpected Pet Peeves

I’ve never considered myself especially peeved at much — more “mildly annoyed, rarely ruffled.” But parenthood has a way of uncovering new depths of daily absurdity. From sprained thumbs to sticky glass tables, here are a few surprisingly specific pet peeves I didn’t see coming.

Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age To study the nuclear phenotypic changes associated with senescence, we designed an in vitro culture system to induce senescence in a myoblast cell line (C2C12) using hydrogen peroxide (H 2 O 2 ) to stimulate oxidative stress and damage (Fig...

Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age
->Nature | #MachineLearning | More info from EcoSearch