Ben Dewals

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

Hallmarks and metabolic regulation of type 2 activated human lung macrophages Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Ou...

Very happy to share our new preprint on hallmarks of human #lung #macrophage activation by type 2 cytokines, and metabolic control of this process 🙂. #immunometabolism #ImmunoSky 🧪 @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social www.biorxiv.org/content/10.1...

IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.

ICYMI: earlier this month in #Science #Immunology, bendewals.bsky.social & colleagues reported that #CD22 expression by virtual #MemoryTCells ( #TVM ) inhibits their expansion in response to #IL4 in the context of #helminth infection !

An unexpected mechanism regulates the immune response during parasitic infections A discovery by ULiège researchers on Virtual Memory T Cells and their activation during parasitic infections in mice

Researchers have just identified a previously unknown mechanism that helps regulate the body's immune response to parasitic infections. This discovery could pave the way for new treatments to better control infections and inflammatory diseases. @science.org
www.news.uliege.be/cms/c_203779...

IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.

Super happy to share our new study now published in #Science #Immunology - www.science.org/doi/10.1126/.... Congrats to first author Bin Yang✨. #IL-4 expand Virtual Memory T cells (TVM) which 'borrow' the normally B-cell restricted CD22 for regulating their activation during #helminth infection.

So nice to see our paper on CD22 regulating #TVMcell during #helminth infection out today 🤗 ! Thanks #Science#Immunology and great editorial work by @hannah-isles.bsky.social

Thanks Helena!

CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

So nice to see our paper on CD22 regulating #TVMcell during #helminth infection out today 🤗 ! Thanks #Science#Immunology and great editorial work by @hannah-isles.bsky.social

And also a huge thanks to journal editor
@hannah-isles.bsky.social for the really smooth review process! A great experience in #Science #Immunology

@universitedeliege.bsky.social @welbio.bsky.social FNRS-F.R.S.

Thanks in particular to collaborators David Vermijlen and Guillem Sanchez Sanchez (TCR treemaps above ⬆️ 💪), @ikinglab.bsky.social (🪱 worms, type 2 inflammation & microbiota), and Lars Nitschke (all about CD22), and to all collaborators !! 👏

In this study, we used scRNAseq and flow in SLOs to show that 1️⃣ CD22 is induced specifically on TVM upon IL-4 stimulation during #helminth infection, 2️⃣ CD22+ TVM have a self-reactive potential, 3️⃣ CD22 reliably identifies IL-4-induced TVM to further study their function, 4️⃣ CD22+ TVM are regulatory

IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.

Super happy to share our new study now published in #Science #Immunology - www.science.org/doi/10.1126/.... Congrats to first author Bin Yang✨. #IL-4 expand Virtual Memory T cells (TVM) which 'borrow' the normally B-cell restricted CD22 for regulating their activation during #helminth infection.

BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses at University of Liverpool on FindAPhD.com PhD Project - BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses at University of Liverpool, listed on FindAPhD.com

www.findaphd.com/phds/project...

BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses at University of Liverpool on FindAPhD.com PhD Project - BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses at University of Liverpool, listed on FindAPhD.com

Interested in immune responses to parasites? Mark Viney, James Hewitson and I have an exciting PhD project available : BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses

Do get in touch if interested!

urldefense.com/v3/__https:/...

Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...

Prospective PhD students...
Please check out this exciting opportunity in Prof. Matt Berriman's lab in Glasgow to investigate how #schistosome eggs interact with tissues of their host to cause #granulomas, co-supervised by yours truly 😊 🪱 🧪 #ImmunoSky
www.gla.ac.uk/postgraduate...

We have a great line up and we are super excited by all the abstracts we have recieved!

Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0

Interested in #mucosalimmunology and the #microbiome? We are looking for a postdoc to join our team at the #RIMUHC at McGill University in Montreal, Canada

Reply here or email me at irah.king@mcgill.ca for more info.

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Check out this landmark paper, hot off the press from Iliyan Iliev’s group (not on Bluesky, yet). www.nature.com/articles/s41... Very grateful to be a part of it!

First Bluesky 🦋 post and the occasion to share the most recent photo of the lab members! We'll have exciting news on helminths, IL-4 and CD8 T cell responses to share soon! 😁