@lreymond.bsky.social
Organic chemistry passionate π§ͺ, mountain addict π§ & freediver π€Ώ. EPFL scientist and @spirochrome.com co-founder. π¨π
The aftermath!
06.12.2025 09:43 β π 0 π 0 π¬ 0 π 0Missed #FluorescenceFriday, but let's go for #GlowingSaturday!
freshly out of the prep JF549 derivative for a colleague
Friday afternoon ski touring isn't a bad concept!
Col de Lys from Les Paccots
The kind of argument that nukes the debate...
01.12.2025 21:57 β π 2 π 0 π¬ 0 π 0Uhhh ugly!
At least it's not a journal cover...
It's the lake of Geneva in Switzerland seen from the mountains above Montreux π
28.11.2025 15:07 β π 1 π 0 π¬ 1 π 0
Snow with lake view for the first ski tour of the year.
28.11.2025 13:27 β π 10 π 0 π¬ 1 π 0A new beautiful proof that Flipper-TR is an excellent reporter of membrane mechanics (and yes membrane are made of lipids β€οΈβπ₯)
27.11.2025 17:39 β π 14 π 2 π¬ 0 π 0The unique mechanosensitive probe Flipper-TR is at the core of an amazing article by @juanmagararc.bsky.social and @rouxlab.bsky.social team of membrane tension experts.
Congratulations!
There is a great 𧡠explaining the key findings how and why cells build membrane tension gradients β¬οΈ
Congrats Juanma and the whole team! I'm lucky you are starting a lab just next door at EPFL.
27.11.2025 17:22 β π 1 π 0 π¬ 0 π 0
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
27.11.2025 14:14 β π 83 π 32 π¬ 6 π 2
Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him
24.11.2025 16:14 β π 28 π 9 π¬ 2 π 1given your bio and the hotspot next to the nucleus which looks like a mtoc, that has to be something that glides on MT!
24.11.2025 16:05 β π 1 π 0 π¬ 1 π 0Nice! what are we looking at?
24.11.2025 14:45 β π 1 π 0 π¬ 1 π 0What's up Bluesky....here's some live-cell imaging taken in my lab
24.11.2025 12:11 β π 38 π 4 π¬ 2 π 0
The images in the main text are also definitely worth a look!
24.11.2025 13:34 β π 1 π 1 π¬ 0 π 0A new article from Nicolas Plachta's lab with incredible imaging of live human embryos using our probes SPY555-DNA and SPY650-FastAct
www.science.org/doi/full/10....
The study shows that frequent errors during cell division directly cause many early developmental failures and morphological defects
In our new #Preprint, we pilot a revolutionary new idea: no supplemental data (it has 21 figures, though):
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Got a connected bird feeder, guests quickly became regular customers! Here a couple of blue tit
22.11.2025 09:04 β π 3 π 0 π¬ 0 π 0
With snow in the garden, that means skiing season is definitely getting closer!
20.11.2025 16:20 β π 5 π 0 π¬ 0 π 0Thank you @prelights.bsky.social for highlighting HAK-actin!
HAK-actin is a great tool for ExM actin staining.
spirochrome.com/product/hak-...
Reliable actin labelling in expansion #microscopy π¬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social β¬οΈπ
prelights.biologists.com/highlights/h...
Quite a busy day on #Bluesky !
Been a while since we have been #preLight -ed !
Discover HAK-Actin if you haven't already ;)
Cool, the HAK-actin preprint was showcased by @prelights.bsky.social
A good reason to read it if you haven't yet π
Fall Alpine landscape with fiery orange larch trees.
3 packs of Swiss cheese fondue mix
A red fondue pot with the Swiss white cross, forks and alcohol burner
Hike'n fondue in Valais with friends! π
The fall colors are splendid.
New preprint π₯³! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out π
www.biorxiv.org/content/10.1...
Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
11.11.2025 18:19 β π 29 π 7 π¬ 2 π 0
A closeup view into a crack in granit with transparent quartz crystals visible.
A cluster of shiny and transparent quartz crystals.
Went looking for quartz over the weekend. I was lucky to find a nice untouched pocket with well-formed crystals (after 3h of search!). The first picture shows the cluster in situ within the crack and the other one shows the same crystals as a detached piece.
10.11.2025 20:23 β π 8 π 0 π¬ 0 π 0Firing water rockets with the kids never gets old, especially for me! π
08.11.2025 15:41 β π 3 π 0 π¬ 0 π 0
Two boxes containing a lot of kiwis
π₯ The kiwi harvest is the last one of the year in the garden.
Happily surprised by the quantity given the very moderate bloom in spring.
