Andreas Kronbichler

Images in Clinical Medicine Periumbilical Erythema Migrans Panel A: A photo of the periumbilical erythema and a small gray protrusion in the umbilicus. Panels B and C: Photos of a tick being extracted from the umbilicus.

An 80-year-old man presented with a 4-day history of a rash on his abdomen. Physical examination was notable for periumbilical erythema and a small gray protrusion in the umbilicus. Read the full case details: nej.md/4pYF5NO

@i-med.ac.at #MedSky #DermSky

Had a super weird case here once, but agree very unlikely! But she was PR3 sky high

IgG4?

Interesting case, indeed. PR3 in the context of C3G rather uncommon. Undetectable C3 would prompt alternative pathway investigations; also in the consideration cryoglobulins and cryofibrinogen, although C4 reduction would be more common

YouTube video by MARKUS at HOMe SGLT-2 I in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller

SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller

youtu.be/9e-UFBnIyDI?...

@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social

Pretty much everything was even surprising to us!

Please also look at the Supplements for all the unique features of the case 😉

Extrarenal “crescent” in multisystem granulomatosis with polyangiitis
doi.org/10.1016/j.kint.2025.03.028
🔹Paravertebral masses in systemic vasculitides such as GPA are rare
🔹This pt had a rupture of the A. colica dextra leading to GI bleeding
#MedSky #NephSky @i-med.ac.at @kronbichlerlab.bsky.social

Absolute rarity; only once when the patient was double-positive and the MPO-ANCA became dominant!

Most will eventually turn anti-GBM antibody negative when established on dialysis! Otherwise, you might consider a dose of rituximab

If kidney is lost and no extrarenal manifestation, there would be no indication to use RTX or CYC, right?

The International Vasculitis Workshop is coming up! One of my favorite meetings for it's sense of community, and possibilities of forming meaningful collaborations (PEXIVAS was hatched in one of them). Call for early career scientists is here
mailchi.mp/icmsaust/ivw...

Figure 3 Association of adherence to CONSORT 2010 statement checklist and trial size. Adherence was positively correlated with number of patients enrolled in the trial.

As the quantity of RCTs in nephrology goes up, how is the quality shaping up?

CONSORT Reporting standards, ANCA vasculitis edition from @abruch.bsky.social @kronbichlerlab.bsky.social et al in @kireports.bsky.social

www.kireports.org/article/S246...

New insights into the biology and treatment of minimal... : Current Opinion in Nephrology and Hypertension sease and focal segmental glomerulosclerosis, there has been a transformation of our understanding of disease pathogenesis and treatment rationale. Recent findings Antinephrin antibodies are common...

It was a pleasure to collaborate with @kronbichlerlab.bsky.social and Dr. Astrid Weins on this article. We describe transformations in our understanding of podocytopathies, and novel treatment approaches in light of those advancements. journals.lww.com/co-nephrolhy...

I was also there and enjoyed the discussions a lot!

Secondary #TMA represent a major unmet medical need.

Grateful for the opportunity to review the role of #complement and discuss when to consider complement inhibitors in these dramatic diseases.

🙏 to outstanding co-authors and the #ERA IWG

@kronbichlerlab.bsky.social
@ndt-era.bsky.social

Understanding the role of anticoagulation in nephrotic syndrome: Please complete this survey - qualtricsxm564785h8t.qualtrics.com/jfe/form/SV_...

It takes 5 minutes and is highly appreciated. 10 more responses are needed

Don’t forget our podocytopathy study 🤣

Congratulations @johannmorelle.bsky.social and team!

Disease-modifying anti-nephropathic drugs (DMANDs) –

a definition proposed by the Immunonephrology Working Group (IWG) of the European Renal Association (ERA)

doi.org/10.1093/ndt/...

👏👏👏 @kronbichlerlab.bsky.social
#FSGS #Nephroticsyndrome #APOL1

just one small note on %FPE/genetics. The concept that genetic forms have ⬇️FPE is confounded. Most FSGS related to slit-diaphragm genes presenting with NS have ⬆️FPE. We see nearly total FPE with TRPC6, INF2, NPHS1, NPHS2, MYO1E et al

Why is rituximab not an option?
It is the most effective treatment option.
I guess there is no experience combining TAC and AVA so far. But I would contact the company (Amgen/CSL Vifor)

A true group effort and work of 2 years! Hope you are enjoying it!

Phenotypic differences between AAV patients in Japan (compared to USA/EU) are obvious. In this study, we surveyed patients presenting during the early phase of the pandemic.

A striking difference in the use of glucocorticoids at 6 months has also been observed!

academic.oup.com/rheumatology...

Positive antineutrophil cytoplasmic antibody serology in patients with lupus nephritis is associated with distinct histopathologic features on renal biopsy - PubMed Class IV-S lupus nephritis is often associated with more necrosis and fewer subendothelial immune deposits compared to class IV-G lupus nephritis, suggestive of necrotising glomerular inflammation fou...

Yes, the Imperial team @kidneydoc101.bsky.social et al. pubmed.ncbi.nlm.nih.gov/28750930/ have published this great article!

Probably also a scenario where I would prefer EuroLupus CYC over MMF as induction therapy!

Sex dimorphism in #kidney health and disease: mechanistic insights and clinical implication

doi.org/10.1016/j.kint.2024.08.038

#OpenAccess #KIReview #AKI #acutekidneyinjury #CKD #kidney #autoimmunedisease #NephSky #SkyNeph #MedSky

Finally, our analysis provides evidence that PR3-ANCA positive patients have a greater likelihood to recover kidney function and the % difference increase was significant!

No difference was seen when we focused on the different GC regimens! That is an important conclusion as recent retrospective data questions the reduced-dose PEXIVAS regimen

Kidney function recovery becomes a relevant endpoint in crescentic GN, which most of us defined as eGFR increase of 15 ml! We see a modest difference between the groups at 52 weeks in favor of PLEX!