Bonev Lab

Congratulations, Jei! 🎉
We’re so proud of your journey and all that you’ve achieved. Thank you for all your incredible contributions! 🎓

In this episode we talked with @boyanbonev.bsky.social from @bonevlab.bsky.social at @epihmgu.bsky.social about his work on neuroepigenetics, focusing on gene regulation, chromatin architecture, and primate epigenome evolution. #podcast #epigenetics

Listen here: activemotif.com/podcasts-boy...

Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...

Can a stem cell change its epigenome while proliferating? In collaboration with the lab of Amos Tanay, we demonstrate that yes, the epigenome of neural stem cells (NSCs) is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14
www.biorxiv.org/content/10.1...

Final Episode of the day completed! #podcast #roadtrip // @boyanbonev.bsky.social @bonevlab.bsky.social

Very happy to share the preprint of my main PhD project in the @bonevlab.bsky.social! Huge thanks to @boyanbonev.bsky.social, all co-authors and members of the @bonevlab.bsky.social! This work wouldn’t have been possible without your contributions!

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...