Rio Sugimura

🔬 February's most-read cancer biology paper: buff.ly/gSjqnmu

Have a paper people should see? See what our Editors look for: buff.ly/mjwHZCb

Congrats Chloe from our lab for the second prize in the HKU Grad School imaging competition. Heart-shaped brain organoids. Cannot wait to integrate with actual heart organoid

Junior Group Leader in Stem Cell Medicine

jobportal.ku.dk/videnskabeli...

great oppurtunity

🚨Don’t forget to apply to this PAID research training in developmental biology‼️ Deadline: February 1st 2026

Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty

Stem Cell Models in Embryology | Keystone Symposia Join us at the Keystone Symposia on Stem Cell Models in Embryology, February 2026, in Pacific Grove, with field leaders!

I'm excited to speak at @keystoneSymposia.bsky.social #StemCell Models of #Embryology, this February! Join me to explore emerging research in Pacific Grove! keysym.us/KSEmbryology26 #KSEmbryology26

Our Blood Engineering Lab is looking for a postdoc candidate. If you would like to join Immuno ChatGPT and AI virtual cell, DM me

Summer Undergraduate Research Experience | HHMI The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

@hhmi.org Summer Undergraduate Research Experience - #CechFellows named in honor of Prof Tom Cech
Deadline to apply: 12/22/2025
Spend 9 weeks in a paid, mentored biomedical research experience in an HHMI lab. See you next summer!!!
www.hhmi.org/programs/cec...

We are thrilled to host Human Embryo Biology and Modeling symposium at @hkusbms.bsky.social .

Human embryos, stem cell embryos, model organisms, single-cell atlas

Nov 26, 2pm-6:30pm

Guojun Sheng, @liliulab.bsky.social , Angela Wu, Rio Sugimura, Tiago Rito, Pentao Liu

The study was led by @chao_yiming now on job market.

Blood originates in hypoblasts during embryonic development

www.biorxiv.org/cgi/content/...

- The first blood comes from the hypoblast that contributes to hemoglobin+ phagocyte-like cells;

- CDX2 marks hypoblast blood that sustains oxygen supply in embryos before heart formation;

- Erythro-core regulatory network endows erythropoiesis to human hypoblasts and phagocytes.

Now we employ CRISPRa and are discovering a core regulatory network to endow erythropoiesis to hypoblast as well as phagocytes. 8/

Indeed, the red cell precursor from hypoblast is mesenchymal and EMT+. What’s more, they are molecularly and functionally similar to phagocytes. What does it mean? Phagocytes are one of the oldest immune cells in evo-devo. What if hypoblast repurposed a phagocyte to give a new role? Carry oxygen? 7/

But the remaining question is, why do we need to make red blood cells so early?
We are actually a macrophage lab, and got inspired at GRC Phagocytes this year.
The heart beats 1 week after blood appears. Blood should do its job without circulation. Should the early blood be snaky and locomotive…? 6

We used two independent human embryo models and LARRY molecular barcoding to identify hypoblast transition to erythroblasts. CDX2 marks such a transition, and its KO led embryo model suffers hypoxia. 5/

Hypoblast was believed to be a dead end of development, only contributing to the yolk sac structure, or AVE. But primate embryos suggest hypoblast may contribute to extraembryonic mesenchymal cells, that we saw in our human embryo models too. 4/

We wondered if some blood might begin before gastrulation. These are epiblast, trophoblast, and hypoblast. Epiblast undergoes gastrulation to follow the long track to make blood. Trophoblast is missing in some embryo models, but we still see such early blood. Then hypoblast…? 3/

We hematologists are taught that all blood starts from gastrulation. When we precisely followed these steps that mimic gastrulation, hematoendothelial mesoderm, and hematopoiesis, it took 2 weeks. But some red cell precursors appear much faster, like a few days… 2/

Our latest preprint.

Blood originates in hypoblasts during embryonic development.

As a blood generator from a petri dish, one question has always stuck in my mind for 15 years. Why does some blood come so fast from iPSC? 1/

Are you looking for a #tenuretrack or #openrank job in #biostatistics or #statistics? @fredhutch.org is hiring! Seattle is a wonderful place to grow your career; the bio/stat & science scene here is world-class; and you will work w/ amazing UW Biostat students. Apply!
apply.interfolio.com/176402

Faculty Professor Associate - Full-Time | Vaughn Cooper We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

Assistant Professor in Molecular Life Science (SciLifeLab Fellow) Do you want to contribute to top quality medical research? Karolinska Institutet (KI) is recruiting researchers as part of the SciLifeLab Fellows program. The successful candidates will join KI and co

We are looking for new SciLifeLab Fellows (group leaders) to join SciLifeLab and Karolinska Institutet @ki.se . @scilifelab.se is a great place to start your lab with generous funding. Deadline: 15th November. Apply and join us in beautiful #Stockholm #JuniorPI ki.varbi.com/en/what:job/...

📢 A Junior Professorship (W1, tenure track) is open at the Center for Plant Molecular Biology at Uni Tübingen (@zmbp-tuebingen.bsky.social) — to work on plant protein biochemistry (composition, structure, dynamics, or regulation of protein complexes). 🌱 Great opportunity — Apply by Oct 17th!

Assistant Professor of Psychology - Human Cognition or Cognitive Neuroscience University of California, Davis is hiring. Apply now!

UC Davis is hiring! A tenure-track assistant professor of psychology, in human cognition or cognitive neuroscience #psychjobs recruit.ucdavis.edu/JPF07300

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87

Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.

Admission to the PhD Programs Gerstner Sloan Kettering offers a unique opportunity to train with some of the world’s leading researchers while developing a deep understanding of today’s clinical challenges. We are looking for high...

MSK’s Gerstner Sloan Kettering Graduate School of Biomedical Sciences is now accepting applications for its Cancer Biology and Cancer Engineering #PhD programs for the 2026 academic year. Apply below:

Huge congrats to our very first PhD student David Xiang for successful defense!
Kudoso to our team, committee members, collaborators to support his work on human gastruloid and critical genes for transcriptional regulation in organogenesis

Are you @ the late stages of your postdoc ? Want to pursue a PI career ?

Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...

Peer-networking / Career orientation and more !!!

Please distribute :) 🙂

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...